{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:03:55Z","timestamp":1781089435304,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Factors influencing unrelated donor selection for allogeneic hematopoietic cell transplantation (HCT) continue to shift. To understand current priorities in step\u2010wise donor selection and guide optimal recruitment for the Canadian Blood Services Stem Cell Registry, we examined changes in donor usage for Canadian patients in 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted of unrelated allogeneic donor transplants in Canada (excluding Quebec) in 2023 with comparison to previous usage and to survey results of transplant center donor selection algorithms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five hundred patients (mean age 51.7\u2009years; 62% male) underwent first transplantation with unrelated human leukocyte antigen (HLA\u2010matched (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009416, 83%) or mismatched adult donors in 2023. Mean donor age was 28.7\u2009years. cytomegalovirus (CMV) concordance in 73% and avoidance of major ABO mismatch in 62% was observed. Selection of Canadian (CDN) donors for CDN patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200950, 10%) is characterized by a preference for HLA\u2010matched, young (\u2264\u200930\u2009years old), male registrants and is positively influenced by availability of donor CMV serostatus and ABO blood group typing at time of initial donor search. When an international donor was used despite the presence of an HLA\u2010matched CDN option, young donor age (\u2264\u200930\u2009years), male sex, and CMV\u2010matching were prioritized. Greater use of HLA\u2010matched donors is observed compared with 2013 and donor factors influencing selection align with survey responses of Canadian transplant centers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>To best serve our patients, HLA\u2010matched CDN stem cell registrants should be young (\u2264\u200930\u2009years), and with CMV and ABO results available at search to facilitate timely selection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70285","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T10:16:22Z","timestamp":1781086582000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in unrelated donor usage for allogeneic hematopoietic cell transplant in Canada: 2013\u20132023 and identifying priorities in donor selection"],"prefix":"10.1111","author":[{"given":"Tanvir","family":"Hasan","sequence":"first","affiliation":[{"name":"Centre for Innovation Canadian Blood Services  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Seftel","sequence":"additional","affiliation":[{"name":"Stem Cells Canadian Blood Services  Ottawa Canada"},{"name":"Faculty of Medicine University of British Columbia  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patti","family":"Wright","sequence":"additional","affiliation":[{"name":"Stem Cells Canadian Blood Services  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Guo","sequence":"additional","affiliation":[{"name":"Stem Cells Canadian Blood Services  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Chartrand","sequence":"additional","affiliation":[{"name":"Stem Cells Canadian Blood Services  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meagan","family":"Green","sequence":"additional","affiliation":[{"name":"Stem Cells Canadian Blood Services  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kareem","family":"Jamani","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Calgary  Calgary Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Auro","family":"Viswabandya","sequence":"additional","affiliation":[{"name":"Princess Margaret Hospital and University Health Network University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gizelle","family":"Popradi","sequence":"additional","affiliation":[{"name":"Health Centre McGill University  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie","family":"Lepic","sequence":"additional","affiliation":[{"name":"Juravinski Cancer Centre McMaster University  Hamilton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"George","sequence":"additional","affiliation":[{"name":"Stem Cell Transplant &amp; Cellular Therapy Program Saskatchewan Cancer Agency  Saskatoon Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harinad","family":"Maganti","sequence":"additional","affiliation":[{"name":"Centre for Innovation Canadian Blood Services  Ottawa Canada"},{"name":"Stem Cells Canadian Blood Services  Ottawa Canada"},{"name":"Faculty of Medicine, University of Ottawa, and Cancer Research Program Ottawa Hospital Research Institute  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Allan","sequence":"additional","affiliation":[{"name":"Stem Cells Canadian Blood Services  Ottawa Canada"},{"name":"Faculty of Medicine, University of Ottawa, and Cancer Research Program Ottawa Hospital Research Institute  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-022-01691-w"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2020.03.002"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol32010010"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2025.05.014"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.02.006"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2024014858"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2023.07.015"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2023.06.020"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO-25-00856"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol31050190"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2020.10.014"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO-25-00206"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14458"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15795"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.29525"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26834"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15182"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70004-9"},{"key":"e_1_2_12_20_1","unstructured":"WMDA.Total number of donors and cord blood units. 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