{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:16:24Z","timestamp":1789168584384,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The safety of red blood cells (RBCs) in additive solutions (AS) for large\u2010volume transfusion (LVT) in pediatrics remains understudied. This study examines the laboratory and clinical impact of CPD\u2010stored products versus CP2D\/AS\u20103 products in pediatric patients receiving LVT during cardiac surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>A retrospective review compared patients undergoing Norwood or heart transplant procedures 28\u2009months before and after a transition from CPD to CP2D\/AS\u20103 blood products. Laboratory values were compared pre\u2010surgery, immediately post\u2010surgery, and 1 day later, along with clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study included 89 patients: 46 in the CPD group and 43 in the AS\u20103 group. Patient weight and transfused RBC, platelet, and cryoprecipitate units were similar between groups. Plasma usage was higher in the AS\u20103 group, and 28% of the CPD group received whole blood. Sodium, glucose, and phosphorus were significantly higher in the AS\u20103 group immediately post\u2010surgery, but not 1\u2009day later. Lactate was significantly higher immediately post\u2010surgery in the AS\u20103 group undergoing Norwood procedure, likely due to their significantly younger age. Conversely, lactate was significantly lower immediately post\u2010surgery in the AS\u20103 group undergoing heart transplants and remained lower on day one. Mortality, total length of stay (LOS), and intensive care unit LOS were similar between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This analysis suggests that AS\u20103 may transiently increase sodium, glucose, and phosphorus immediately after LVT during pediatric cardiac surgery. These changes are consistent with LVT exposure to CP2D\/AS\u20103 and fully resolved by 24\u2009h, with no effect on patient mortality or LOS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70297","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:26:52Z","timestamp":1781796412000},"page":"1721-1726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Red blood cells stored in anticoagulant versus additive solution for large volume transfusions in pediatric patients undergoing cardiopulmonary bypass"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1646-9201","authenticated-orcid":false,"given":"Nabiha H.","family":"Saifee","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Seattle Children's  Seattle Washington USA"},{"name":"Department of Laboratory Medicine and Pathology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1089-5787","authenticated-orcid":false,"given":"Meghan","family":"Delaney","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Children's National Hospital  Washington DC USA"},{"name":"Department of Pathology and Pediatrics George Washington University Medical School  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1996.361097017172.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(00)70104-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7210545"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16520"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/voxs.12343"},{"key":"e_1_2_10_7_1","volume-title":"2002 ASCP\/CAP Meeting","author":"Eder AF","year":"2002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2010.00993.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02668.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2020.06.009"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13402"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000282110"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1991.31391165172.x"},{"key":"e_1_2_10_14_1","unstructured":"Association for the Advancement of Blood and Biotherapies (AABB).Association Bulletin #26\u201303. RE: Neonatal Red Blood Cell Transfusion and Mannitol Exposure.2026[cited 2026 May 28] Available from:https:\/\/www.aabb.org\/docs\/default-source\/default-document-library\/resources\/association-bulletins\/ab26-03.pdf"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1976.16376225498.x"},{"key":"e_1_2_10_16_1","unstructured":"Mannitol package insert. Lake Forest IL: Hospira.2024."}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70297","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.70297","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:51:32Z","timestamp":1789167092000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.70297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,18]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/trf.70297"],"URL":"https:\/\/doi.org\/10.1111\/trf.70297","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,18]]},"assertion":[{"value":"2026-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}