{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:15:11Z","timestamp":1789168511070,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R34 HL159119"],"award-info":[{"award-number":["R34 HL159119"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["U24TR001597"],"award-info":[{"award-number":["U24TR001597"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Children supported by extracorporeal membrane oxygenation (ECMO) frequently receive platelet transfusions. However, little is known about how characteristics of platelet products affect transfusion effectiveness in ECMO patients. Our objective was to evaluate whether platelet product characteristics were associated with platelet count increment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>Secondary analysis of the ECSTATIC randomized controlled trial. Children &lt;18\u2009years on ECMO were randomized to two prophylactic platelet transfusion threshold strategies. In this secondary analysis, the exposure was platelet transfusions characterized by storage duration, ABO compatibility, platelet additive solution, irradiation, and pathogen reduction status. The primary outcome was the platelet count increment after transfusion, dichotomized as higher versus lower based on the median value. Regression models were used to identify associations between product characteristics and platelet count increment, adjusting for clustering.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 161 transfusions among 27 participants met inclusion criteria. The median change in platelet count was 19\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      cell\/L (IQR 8; 36), and the median time from pre\u2010transfusion to post\u2010transfusion count was 5.9\u2009h (IQR 4.8; 7.1). In univariable analysis, pathogen reduction was associated with a lower platelet count increment (odds ratio\u2009=\u20090.14,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.01). In a multivariable model, higher pre\u2010transfusion platelet count was independently associated with increased platelet count increment (adjusted odds ratio [aOR]\u2009=\u20091.03,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.049), while pathogen reduction was independently associated with decreased count increment (aOR\u2009=\u20090.16,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.048).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among critically ill children on ECMO, pathogen\u2010reduction and pre\u2010transfusion platelet count may influence the effectiveness of transfusion. These findings support the need for prospective trials that incorporate product\u2010level characteristics into transfusion strategies for pediatric ECMO patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70299","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:42:09Z","timestamp":1781797329000},"page":"1727-1736","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of platelet characteristics on post\u2010transfusion count response in critically ill children on\n                    <scp>Extracorporeal Membrane Oxygenation<\/scp>\n                    : A secondary analysis of the\n                    <scp>ECSTATIC<\/scp>\n                    trial"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6606-1736","authenticated-orcid":false,"given":"Oliver","family":"Karam","sequence":"first","affiliation":[{"name":"Department of Pediatrics Pediatric Critical Care Medicine, Yale  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley J.","family":"Barney","sequence":"additional","affiliation":[{"name":"Utah Data Coordinating Center and Department of Pediatrics University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garrett","family":"Coles","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Medicine, Department of Pediatrics University of Rochester Golisano Children's Hospital  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarif A.","family":"Choudhury","sequence":"additional","affiliation":[{"name":"Divisions of Pediatric Critical Care Medicine and Pediatric Cardiology Morgan Stanley Children's Hospital at Columbia University School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1659-6884","authenticated-orcid":false,"given":"Jamie","family":"Furlong\u2010Dillard","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Medicine, Department of Pediatrics University of Louisville Norton Children's Hospital  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Ozment","sequence":"additional","affiliation":[{"name":"Pediatric Critical Care Medicine Duke University  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Bain","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine Children's Hospital of Richmond at VCU  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1587-1912","authenticated-orcid":false,"given":"Robert A.","family":"Niebler","sequence":"additional","affiliation":[{"name":"Division of Critical Care, Department of Pediatrics Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1375-6988","authenticated-orcid":false,"given":"Madhuradhar","family":"Chegondi","sequence":"additional","affiliation":[{"name":"Pediatric Critical Care Medicine University of Illinois College of Medicine and Children's Hospital of Illinois at OSF HealthCare  Peoria Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer","family":"Schiller","sequence":"additional","affiliation":[{"name":"Pediatric Cardiac Intensive Care Unit, Schneider Children's Medical Center Petach\u2010Tikva and Tel\u2010Aviv University, Faculty of Medicine and Health Sciences  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umesh","family":"Joashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Paden","sequence":"additional","affiliation":[{"name":"Children's Healthcare of Atlanta, Emory  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2697-6314","authenticated-orcid":false,"given":"Marianne E.","family":"Nellis","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the ECSTATIC collaborators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Blood Net and PediECMO, subgroups of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005435"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.322752"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.09.003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1339235"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/02676591221151027"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0000000000004417"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/pcc.0000000000002102"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2023.113666"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16094"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001779"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2018.04.001"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1757897"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.673613"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000006995"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31828a2bbd"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/pcc.0000000000002160"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003192"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15807"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2018.06.002"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.260430"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-02-831289"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009072.pub3"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2724"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2024014143"},{"key":"e_1_2_9_26_1","unstructured":"ELSO.ELSO Registry International Summary [Internet].2025[cited 2025 Dec 4]. Available from:https:\/\/www.elso.org\/registry\/internationalsummaryandreports\/internationalsummary.aspx"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70299","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.70299","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:51:41Z","timestamp":1789167101000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.70299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,18]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/trf.70299"],"URL":"https:\/\/doi.org\/10.1111\/trf.70299","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,18]]},"assertion":[{"value":"2025-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}