{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:43:52Z","timestamp":1792158232943,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["20H0258"],"award-info":[{"award-number":["20H0258"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["20H0269"],"award-info":[{"award-number":["20H0269"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The Lan antigen is a high\u2010prevalence red blood cell antigen encoded by the ATP binding cassette subfamily B member 6 (\n                      <jats:italic>ABCB6<\/jats:italic>\n                      ) gene. Variants in this gene are responsible for Lan null and variant phenotypes. Individuals lacking the Lan antigen may develop anti\u2010Lan antibodies following sensitizing events such as transfusion or pregnancy. Hemolytic disease of the fetus and newborn (HDFN) caused by anti\u2010Lan antibodies is extremely rare.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>\n                      We report a case of a Chinese pregnant woman carrying a novel homozygous variant in exon 17 of the\n                      <jats:italic>ABCB6<\/jats:italic>\n                      gene (NM_005689.4:c.2312_2313del), resulting in a Lan null phenotype. Anti\u2010Lan antibodies were detected in maternal plasma, neonatal plasma, and cord blood eluate. The newborn developed mild HDFN, which resolved spontaneously without intervention, leading to a favorable outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This represents the first documented case of anti\u2010Lan\u2010mediated HDFN in an Asian population and the fifth case worldwide. Our findings expand the genetic diversity and geographic spectrum of this rare condition and provide important insights for clinical management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70319","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:25:28Z","timestamp":1783697128000},"page":"2025-2030","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A novel homozygous\n                    <scp>\n                      <i>ABCB6<\/i>\n                    <\/scp>\n                    variant causing the Lan null phenotype and anti\u2010Lan\u2010mediated hemolytic disease of the fetus and newborn: A case report and a review of anti\u2010Lan in pregnancy"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1229-4352","authenticated-orcid":false,"given":"Jing","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine West China Second University Hospital, Sichuan University  Chengdu China"},{"name":"Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Tian","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion Chinese Academy of Medical Sciences and Peking Union Medical College  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Molecular Immunohematology Lab Shanghai Institute of Blood Transfusion, Shanghai Blood Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine West China Second University Hospital, Sichuan University  Chengdu China"},{"name":"Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine West China Second University Hospital, Sichuan University  Chengdu China"},{"name":"Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7765-2985","authenticated-orcid":false,"given":"Hong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine West China Second University Hospital, Sichuan University  Chengdu China"},{"name":"Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyi","family":"Ye","sequence":"additional","affiliation":[{"name":"Molecular Immunohematology Lab Shanghai Institute of Blood Transfusion, Shanghai Blood Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0327-8364","authenticated-orcid":false,"given":"Jian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine West China Second University Hospital, Sichuan University  Chengdu China"},{"name":"Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2026.102731"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_407_25"},{"key":"e_1_2_11_4_1","first-page":"493","volume-title":"Ho and Lan: two new blood group antigens (conference abstract). Proceedings of the 8th congress of the European Society of Haematology","author":"Hart M","year":"1962"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1069"},{"key":"e_1_2_11_6_1","volume-title":"ISBT working party on red cell Immunogenetics and blood group terminology. LAN blood group alleles [internet]","year":"2023"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5662.90"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1983.23383224909.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1987.27187121460.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12473"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-024-10148-x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12285"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.21307\/immunohematology-2019-135"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118493595"},{"key":"e_1_2_11_15_1","first-page":"583","article-title":"Screening of some rare blood groups in Shanghai area population","volume":"22","author":"Wang C","year":"2007","journal-title":"Jianyan Yixue"},{"key":"e_1_2_11_16_1","first-page":"286","article-title":"Clinical and genetic analysis of an individual with Lan\u2010negative rare blood group due to variant of ABCB6 gene","volume":"42","author":"Xu XG","year":"2025","journal-title":"Chin J Med Genet"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70319","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.70319","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:44:36Z","timestamp":1792154676000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.70319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,10]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/trf.70319"],"URL":"https:\/\/doi.org\/10.1111\/trf.70319","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,10]]},"assertion":[{"value":"2026-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}