{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:21:11Z","timestamp":1787818871835,"version":"build-2784847793"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clinical practice guidelines for red blood cell (RBC) or platelet transfusion are not tailored specifically for therapeutic apheresis patients. It is unclear how provider transfusion thresholds in the peri\u2010therapeutic apheresis period correlate with guidelines. We hypothesized that individual apheresis clinician practice would not wholly adhere to transfusion guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>\n                      A large, international survey was designed, beta tested, piloted and sent to all members of the Association for the Advancement of Blood &amp; Biotherapies (AABB) Therapeutic Apheresis Subsection (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009459). Responses of interest were used to generate discussion points for an open, expert\u2010moderated focus group discussion at the 2024 AABB Annual Meeting.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Total survey response rate was 10%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200947. Calculated sample size (survey responses) for 95% confidence level with a 10% margin of error was\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200980. Nonetheless, responses of interest were generated, including some responses deemed discordant with international guidelines. Five topics were discussed by the focus groups: (1) platelet transfusion thresholds, (2) transfusion methods prior to central venous catheter placement, (3) therapeutic plasma exchange platelet repletion, (4) hemoglobin transfusion threshold prior to RBC exchange, and (5) platelet transfusion threshold for initiating therapeutic plateletpheresis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The survey results and focus group discussion, framed within current international guidelines and the literature, highlighted the need for enhancing the value of apheresis providers' clinical judgment and ability to impact institutional policies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70348","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:11:27Z","timestamp":1787818287000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transfusion thresholds in apheresis: Results from a survey and focus group discussion"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7192-5057","authenticated-orcid":false,"given":"Kyle","family":"Annen","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Children's Hospital Colorado  Aurora Colorado USA"},{"name":"Department of Pathology University of Colorado\u2013Anschutz School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay S.","family":"Raval","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Robert Larner, M.D. College of Medicine, University of Vermont  Burlington Vermont USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2951-0034","authenticated-orcid":false,"given":"Gaurav K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9506-6971","authenticated-orcid":false,"given":"Monika","family":"Paroder\u2010Belenitsky","sequence":"additional","affiliation":[{"name":"Department of Pathology Montefiore Medical Center\/Albert Einstein College of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7800-3119","authenticated-orcid":false,"given":"Yvette C.","family":"Tanhehco","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9881-703X","authenticated-orcid":false,"given":"Suzanne R.","family":"Thibodeaux","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Immunology WashU Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7246-4486","authenticated-orcid":false,"given":"Jennifer M.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2292-3167","authenticated-orcid":false,"given":"Wen","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole D.","family":"Zantek","sequence":"additional","affiliation":[{"name":"ClinImmune: The Center for Clinical Immunology, Department of Medicine University of Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7836-0132","authenticated-orcid":false,"given":"Louise J.","family":"Helander","sequence":"additional","affiliation":[{"name":"ClinImmune: The Center for Clinical Immunology, Department of Medicine University of Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Transfusion Medicine, Division of Hematology\/Oncology and Department of Medicine University of Massachusetts Memorial Medical Center  Worchester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter E.","family":"Kelley","sequence":"additional","affiliation":[{"name":"BioLife Medical Affairs, Takeda  Bannockburn Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Glatt","sequence":"additional","affiliation":[{"name":"South African National Blood Service  Johannesburg Gauteng South\u00a0Africa"},{"name":"Department of Molecular Medicine and Hematology University of Witwatersrand  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadhana","family":"Mangwana","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Sri Balaji Action Medical Institute  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0480-0449","authenticated-orcid":false,"given":"Jensyn","family":"Cone Sullivan","sequence":"additional","affiliation":[{"name":"Department of Pathology Michigan Medicine  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02505.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","unstructured":"Red Blood Cell Transfusion 2023 AABB International Guidelines.https:\/\/doi.org\/10.1001\/jama.2023.12914","DOI":"10.1001\/jama.2023.12914"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","unstructured":"Platelet Transfusion 2025 AABB and ICTMG International Clinical Practice Guidelines.https:\/\/doi.org\/10.1001\/jama.2025.7529","DOI":"10.1001\/jama.2025.7529"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15861"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15009"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-1589"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.743483"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0046"},{"issue":"6","key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1097\/MOH.0000000000000542","article-title":"Neonatal and pediatric platelet transfusions: current concepts and controversies","volume":"26","author":"Patel RM","year":"2019","journal-title":"Curr Opin Hematol"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.22043"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2025.06.002"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.762419"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.13150"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2026.150979"},{"key":"e_1_2_9_16_1","unstructured":"L\u00f3pezJI.The invisible doctor. 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