{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T17:28:03Z","timestamp":1786382883507,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Frequent plasma donation is associated with reduced circulating IgG levels, prompting many jurisdictions to apply IgG\u2010based deferral thresholds as a precautionary donor\u2010safety measure. However, whether low IgG in healthy individuals reflects clinically meaningful immunosuppression remains unclear. This study evaluated IgG as a marker for donor health by integrating immunological, behavioral and self\u2010reported outcomes, including vaccine responses, return to donation, and health problems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>The kinetics of IgG decline associated with frequent plasma donation were analyzed over 18\u2009months in 49 first\u2010time and 50 repeat donors. Vaccine responses were evaluated in repeat donors with low or high IgG using ELISA to measure SARS\u2010CoV\u20102 Spike receptor\u2010binding domain antibodies and avidity after primary and booster COVID\u201019 vaccination. Return to plasma donation was examined in 3897 first\u2010time plasma donors followed up to 22\u2009months. Self\u2010reported health problems were analyzed in 5347 plasma donors over 10\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>IgG levels declined during early donations in first\u2010time donors but stabilized thereafter, suggesting a new homeostatic set point rather than progressive IgG depletion. All vaccinated donors seroconverted after primary vaccination regardless of IgG level. Although antibody levels were slightly lower in low\u2010IgG donors, affinity maturation was comparable after boosting. IgG levels were not associated with return to donation or increased self\u2010reported health problems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Low IgG levels in healthy plasma donors were not associated with impaired immunity, donor retention, or increased self\u2010reported health problems. These findings support cautious interpretation of isolated IgG values in donor management and favor longitudinal monitoring over fixed thresholds.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70373","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T16:32:03Z","timestamp":1786379523000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relevance of circulating\n                    <scp>IgG<\/scp>\n                    levels as a marker of health in plasma donors"],"prefix":"10.1111","author":[{"given":"Audrey","family":"Laforce\u2010Lavoie","sequence":"first","affiliation":[{"name":"Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessyka","family":"Desch\u00eanes","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation 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