{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:18:35Z","timestamp":1788261515387,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Plerixafor (P) is a rescue mobilization agent given to improve circulating CD34+ for peripheral blood stem cell (PBSC) collection in donors with inadequate response to granulocyte colony\u2010stimulating factor (G\u2010CSF, [G]). In this study, we evaluated the impact of immediate plerixafor administration without leukapheresis interruption for the same\u2010day PBSC collection in G\u2010mobilized allogeneic donors with pre\u2010apheresis peripheral blood CD34+ count \u226430\/\u03bcL.<\/jats:p>\n <\/jats:sec>\n \n Study Design<\/jats:title>\n \n Retrospective analysis of two\u2010center data from 10\/2023 to 11\/2025 was conducted. The study group (G\u2009+\u2009P) received G\u2010CSF for 5\u2009days and plerixafor without leukapheresis interruption (\n n<\/jats:italic>\n \u2009=\u200912). The control group (G,\n n<\/jats:italic>\n \u2009=\u200924) received 5\u2010day\u2009G\u2010CSF and had similar median apheresis procedure time as study group. Outcomes were evaluated at early procedure (EP) and late procedure (LP) periods, separated by the timing of the interim PBSC product characterization.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n G\u2009+\u2009P donors did not experience increased platelet loss or grade 2 or greater adverse reactions in gastrointestinal and immune systems or required day\u20102 collection. During the LP period, G\u2009+\u2009P group had approximately 5.5\u2010fold increase in median CD34+ cells\/L processed\/h apheresis (\n p<\/jats:italic>\n \u2009<\u2009.0001). During the LP period, while G\u2009+\u2009P group had significant gains in CD34+ yield, there was a significant loss in the control group (\n p<\/jats:italic>\n \u2009<\u2009.0087). CD34+ collection efficiency was significantly higher in G\u2009+\u2009P (\n p<\/jats:italic>\n \u2009<\u2009.0001). All PBSC products from G\u2009+\u2009P group contained \u22654.5\u2009\u00d7\u200910\n 6<\/jats:sup>\n CD34+\/kg recipient while only 63% of controls met this threshold (\n p<\/jats:italic>\n \u2009=\u2009.016).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Same\u2010day rescue plerixafor without leukapheresis interruption in allogeneic donors suboptimally responding to G\u2010CSF results in safe and efficient leukapheresis collection while preserving PBSC product quality.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/trf.70376","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:49:51Z","timestamp":1788259791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Same\u2010day rescue plerixafor during leukapheresis is safe and effective in allogeneic donors suboptimally responding to granulocyte colony\u2010stimulating factor mobilization"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9239-4980","authenticated-orcid":false,"given":"Yen\u2010Michael S.","family":"Hsu","sequence":"first","affiliation":[{"name":"Gift of Life Marrow Registry, Adelson\u2010NMDP Collection Center Boca Raton Florida USA"},{"name":"Gift of Life Marrow Registry, Center for Cell and Gene Therapy Boca Raton Florida USA"},{"name":"Clinical Research, Gift of Life Marrow Registry Boca Raton Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8132-0195","authenticated-orcid":false,"given":"Amy","family":"Ellsworth","sequence":"additional","affiliation":[{"name":"NMDP Seattle Apheresis Collection Center Seattle Washington USA"},{"name":"NMDP Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Independent Researcher San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeramy","family":"Davies","sequence":"additional","affiliation":[{"name":"NMDP Seattle Apheresis Collection Center Seattle Washington USA"},{"name":"NMDP Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Erskine","sequence":"additional","affiliation":[{"name":"NMDP Seattle Apheresis Collection Center Seattle Washington USA"},{"name":"NMDP Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Miller","sequence":"additional","affiliation":[{"name":"NMDP Seattle Apheresis Collection Center Seattle Washington USA"},{"name":"NMDP Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0651-8666","authenticated-orcid":false,"given":"Kimberly A.","family":"Kasow","sequence":"additional","affiliation":[{"name":"NMDP Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0554-3213","authenticated-orcid":false,"given":"Heather E.","family":"Stefanski","sequence":"additional","affiliation":[{"name":"NMDP Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richaele","family":"Nichiporenko","sequence":"additional","affiliation":[{"name":"Gift of Life Marrow Registry, Adelson\u2010NMDP Collection Center Boca Raton Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Margolis","sequence":"additional","affiliation":[{"name":"NMDP Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2516-7969","authenticated-orcid":false,"given":"Kathleen","family":"Burke","sequence":"additional","affiliation":[{"name":"NMDP Seattle Apheresis Collection Center Seattle Washington USA"},{"name":"NMDP Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Galloway","sequence":"additional","affiliation":[{"name":"Gift of Life Marrow Registry, Adelson\u2010NMDP Collection Center Boca Raton Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Knutson","sequence":"additional","affiliation":[{"name":"NMDP Seattle Apheresis Collection Center Seattle Washington USA"},{"name":"NMDP Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ondricek","sequence":"additional","affiliation":[{"name":"NMDP Seattle Apheresis Collection Center Seattle Washington USA"},{"name":"NMDP Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farida","family":"Khan","sequence":"additional","affiliation":[{"name":"Gift of Life Marrow Registry, Center for Cell and Gene Therapy Boca Raton Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hope","family":"Guidry\u2010Groves","sequence":"additional","affiliation":[{"name":"NMDP Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Feinberg","sequence":"additional","affiliation":[{"name":"Gift of Life Marrow Registry, Adelson\u2010NMDP Collection Center Boca Raton Florida USA"},{"name":"Gift of Life Marrow Registry, Center for Cell and Gene Therapy Boca Raton Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Fisher","sequence":"additional","affiliation":[{"name":"Gift of Life Marrow Registry, Adelson\u2010NMDP Collection Center Boca Raton Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Johnson","sequence":"additional","affiliation":[{"name":"Gift of Life Marrow Registry, Adelson\u2010NMDP Collection Center Boca Raton Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Retterath","sequence":"additional","affiliation":[{"name":"Gift of Life Marrow Registry, Adelson\u2010NMDP Collection Center Boca Raton Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A.","family":"Lenes","sequence":"additional","affiliation":[{"name":"Gift of Life Marrow Registry, Adelson\u2010NMDP Collection Center Boca Raton Florida USA"},{"name":"Gift of Life Marrow Registry, Center for Cell and Gene Therapy Boca Raton Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7731-759X","authenticated-orcid":false,"given":"Steven","family":"Devine","sequence":"additional","affiliation":[{"name":"NMDP Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4168-3859","authenticated-orcid":false,"given":"Huy P.","family":"Pham","sequence":"additional","affiliation":[{"name":"NMDP Seattle Apheresis Collection Center Seattle Washington USA"},{"name":"NMDP Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1634\/stemcells.19-2-108","article-title":"Peripheral blood stem cells for allogeneic transplantation: a review","volume":"19","author":"Cutler C","year":"2001","journal-title":"Stem Cells"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1159\/000531236","article-title":"Predicting successful hematopoietic stem cell collection in healthy allogeneic donors","volume":"50","author":"Kayser S","year":"2023","journal-title":"Transfus Med Hemother"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.bbmt.2020.02.011","article-title":"Collection of 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myeloma","volume":"113","author":"DiPersio JF","year":"2009","journal-title":"Blood"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2147\/JBM.S307520","article-title":"Use of Plerixafor for stem cell mobilization in the setting of autologous and allogeneic stem cell transplantations: an update","volume":"12","author":"Bilgin YM","year":"2021","journal-title":"J Blood Med"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1111\/bjh.19963","article-title":"UK consensus statement on the use of plerixafor in healthy stem cell donors","volume":"206","author":"Dexter T","year":"2025","journal-title":"Br J Haematol"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"551.e1","DOI":"10.1016\/j.jtct.2026.01.021","article-title":"World marrow donor association statement on the use of Plerixafor in healthy donors","volume":"32","author":"Dexter T","year":"2026","journal-title":"Transplant Cell 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CD34+?","volume":"64","author":"Ozkan SG","year":"2024","journal-title":"Transfusion"},{"key":"e_1_2_8_25_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.transci.2025.104297","article-title":"Balancing accuracy and efficiency in peripheral blood stem cell collection: a protocol comparison study","volume":"65","author":"Sharma N","year":"2026","journal-title":"Transfus Apher Sci"},{"key":"e_1_2_8_26_1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1537-2995.2005.04222.x","article-title":"Augmented mobilization and collection of CD34+ hematopoietic cells from normal human volunteers stimulated with granulocyte\u2010colony\u2010stimulating factor by single\u2010dose administration of AMD3100, a CXCR4 antagonist","volume":"45","author":"Liles WC","year":"2005","journal-title":"Transfusion"},{"key":"e_1_2_8_27_1","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1080\/10428190290033323","article-title":"Dose and schedule effect of G\u2010GSF for stem cell mobilization in healthy donors for allogeneic transplantation","volume":"43","author":"Kroger N","year":"2002","journal-title":"Leuk Lymphoma"},{"key":"e_1_2_8_28_1","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/s41591-023-02273-z","article-title":"Motixafortide and G\u2010CSF to mobilize hematopoietic stem cells for autologous transplantation in multiple myeloma: a randomized phase 3 trial","volume":"29","author":"Crees ZD","year":"2023","journal-title":"Nat Med"},{"key":"e_1_2_8_29_1","doi-asserted-by":"crossref","first-page":"5210","DOI":"10.1182\/bloodadvances.2023010407","article-title":"Hematopoietic stem cell mobilization for allogeneic stem cell transplantation by motixafortide, a novel CXCR4 inhibitor","volume":"7","author":"Crees ZD","year":"2023","journal-title":"Blood Adv"},{"key":"e_1_2_8_30_1","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1182\/blood-2016-09-739722","article-title":"Mobilization of allogeneic peripheral blood stem cell donors with intravenous plerixafor mobilizes a unique graft","volume":"129","author":"Schroeder MA","year":"2017","journal-title":"Blood"},{"key":"e_1_2_8_31_1","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1182\/bloodadvances.2018027599","article-title":"Plerixafor alone for the mobilization and transplantation of HLA\u2010matched sibling donor hematopoietic stem cells","volume":"3","author":"Chen YB","year":"2019","journal-title":"Blood 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