{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:44:00Z","timestamp":1792158240923,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000014","name":"Canadian Blood Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000014","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2026,10]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Public access to up\u2010to\u2010date information on infectious diseases and outbreaks has grown rapidly with the advent of artificial intelligence platforms. While this information can improve patient care and support research, the sheer volume of available data coupled with the challenge of identifying misinformation and disinformation can be overwhelming. A key challenge is managing large information volumes and identifying early, subtle signals that may indicate risks or opportunities to prevent infection. The aim of this manuscript is to explain how a national blood operator identifies and evaluates subtle infectious disease signals generated by horizon scanning to proactively protect the blood supply, including biotherapy products.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Horizon scanning protocols were developed to detect early signals of change (emerging\/re\u2010emerging pathogens, geopolitical\/environmental changes, scientific and technological advances, new therapies\/treatments for infectious diseases, and blood operator transfusion medicine changes). Communication strategies were created to alert national and international transfusion medicine decision makers of blood safety\u2010related events.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Several key components of a horizon scanning approach are presented to illustrate how novel information can be identified, processed, and formulated into knowledge translation products. Efficient and cost\u2010effective approaches are presented to enable horizon scanning activities with limited resources and time commitments.<\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n Horizon scanning is an efficient and necessary activity to safeguard the blood supply. Here we present a collaborative group\u2010based approach, which reduces operator bias and improves overall examination of multiple data sources. This approach does not require expensive technology, can focus on open\u2010source information, and engages new scientists in learning about infectious diseases.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/trf.70388","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:10:21Z","timestamp":1789823421000},"page":"1902-1909","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["How does a national blood operator detect early infectious disease signals affecting blood and cellular therapy product safety and sufficiency?"],"prefix":"10.1111","volume":"66","author":[{"given":"Leisa","family":"Bruneau","sequence":"first","affiliation":[{"name":"Surveillance and Discovery Laboratory Canadian Blood Services Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9129-5136","authenticated-orcid":false,"given":"Carmen L.","family":"Charlton","sequence":"additional","affiliation":[{"name":"Medical Microbiology, Innovation Canadian Blood Services Ottawa Ontario Canada"},{"name":"Division of Diagnostic and Applied Microbiology, Department of Laboratory Medicine and Pathology University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0705-4987","authenticated-orcid":false,"given":"Sandra","family":"Ramirez\u2010Arcos","sequence":"additional","affiliation":[{"name":"Medical Microbiology, Innovation Canadian Blood Services Ottawa Ontario Canada"},{"name":"Department of Biochemistry, Microbiology and Immunology University of Ottawa Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilini","family":"Kumaran","sequence":"additional","affiliation":[{"name":"Surveillance and Discovery Laboratory Canadian Blood Services Ottawa Ontario Canada"},{"name":"Medical Microbiology, Innovation Canadian Blood Services Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3261-8289","authenticated-orcid":false,"given":"David","family":"Allan","sequence":"additional","affiliation":[{"name":"Transplant & Cellular Therapy, Hematology, Department of Medicine The Ottawa Hospital Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Norman","sequence":"additional","affiliation":[{"name":"Stem Cells Canadian Blood Services Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Seftel","sequence":"additional","affiliation":[{"name":"Stem Cells Canadian Blood Services Vancouver British Columbia Canada"},{"name":"Department of Medicine University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8181-9517","authenticated-orcid":false,"given":"Evan M.","family":"Bloch","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine, Department of Pathology Johns Hopkins University Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4512-7545","authenticated-orcid":false,"given":"Chantale","family":"Pambrun","sequence":"additional","affiliation":[{"name":"Innovation Canadian Blood Services Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5332-2789","authenticated-orcid":false,"given":"Sheila F.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Medical Affairs Canadian Blood Services Ottawa Ontario Canada"},{"name":"School of Epidemiology and Public Health University of Ottawa Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Cranney","sequence":"additional","affiliation":[{"name":"Surveillance and Discovery Laboratory Canadian Blood Services Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2519-1109","authenticated-orcid":false,"given":"Steven J.","family":"Drews","sequence":"additional","affiliation":[{"name":"Medical Microbiology, Innovation Canadian Blood Services Ottawa Ontario Canada"},{"name":"Division of Diagnostic and Applied Microbiology, Department of Laboratory Medicine and Pathology University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rser.2017.09.087"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02759"},{"key":"e_1_2_10_4_1","volume-title":"New WHO report reveals governments deprioritizing health spending","author":"World Health Organization","year":"2024"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42522-026-00197-5"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.70162"},{"key":"e_1_2_10_7_1","volume-title":"Global pulse horizon scan user manual","author":"United Nations","year":"2022"},{"key":"e_1_2_10_8_1","volume-title":"Countering disinformation effectively: an evidence\u2010based policy guide [Internet]","author":"Bateman J","year":"2024"},{"key":"e_1_2_10_9_1","volume-title":"Safety of human cells, tissues and organs for 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