{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:56:27Z","timestamp":1790679387302,"version":"4.1.0"},"reference-count":7,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Patients with sickle cell disease (SCD) frequently require specialized transfusion support. However, the blood bank cannot readily identify these patients without a time\u2010prohibitive chart review. To improve adherence to evidence\u2010based practices involving the transfusion of patients with SCD, we developed a laboratory information system (LIS)\u2010integrated flagging system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>Using a predefined set of SCD\u2010related International Classification of Diseases\u201010 diagnosis codes, laboratory\u2010facing flags were implemented within the LIS. Flags were displayed in multiple workflow locations, including the patient dashboard, blood bank specimen receiving interface, and blood bank outstanding work list.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Blood bank technologists used the flags to verify and apply the institution's existing sickle cell transfusion protocol within the blood bank information system (BBIS). Thirty\u2010three new patients with confirmed SCD but without historical comment in the BBIS had a type and screen performed after the implementation of the flag. Upon review, 4 (12%) did not have SCD\u2010related diagnosis in their problem list and therefore lacked the trigger for the flag. Twenty\u2010nine (88%) patients had the diagnosis in the problem list and all of them (100%) correctly displayed the flag.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and Conclusion<\/jats:title>\n                    <jats:p>The intervention provided additional alerts of patients with SCD across multiple laboratory workflows and aided in the recognition of eligible patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70417","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:09:52Z","timestamp":1790676592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnosis\u2010based laboratory information system flags to support specialized transfusion protocols in sickle cell disease"],"prefix":"10.1111","author":[{"given":"Caroline G.","family":"Stanek","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7361-7162","authenticated-orcid":false,"suffix":"III","given":"Ronald G.","family":"Hauser","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Madden","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yale New Haven Health System  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhushan","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yale New Haven Health System  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1785-2245","authenticated-orcid":false,"given":"Christopher A.","family":"Tormey","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Wallack","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yale New Haven Health System  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7807-6046","authenticated-orcid":false,"given":"Nalan","family":"Yurtsever","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1182\/bloodadvances.2019001143","article-title":"American Society of Hematology 2020 guidelines for sickle cell disease: transfusion support","volume":"4","author":"Chou ST","year":"2020","journal-title":"Blood Adv"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1056\/NEJMsa020847","article-title":"Improving safety with information technology","volume":"348","author":"Bates DW","year":"2003","journal-title":"N Engl J Med"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/2153-3539.74961","article-title":"Contemporary issues in transfusion medicine informatics","volume":"2","author":"Sharma G","year":"2011","journal-title":"J Pathol Inform"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2025.110120","article-title":"How to improve blood transfusion safety through information technology and practices","volume":"190","author":"Chen P","year":"2025","journal-title":"Comput Biol Med"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/1475-6773.13257","article-title":"Performance of ICD\u201010\u2010CM diagnosis codes for identifying children with sickle cell anemia","volume":"55","author":"Reeves SL","year":"2020","journal-title":"Health Serv Res"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","DOI":"10.2196\/42816","article-title":"Evaluating the discriminatory ability of the sickle cell data collection Program's administrative claims case definition in identifying adults with sickle cell disease: validation study","volume":"9","author":"Singh A","year":"2023","journal-title":"JMIR Public Health Surveill"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.28703","article-title":"Administrative data identify sickle cell disease: a critical review of approaches in U.S. health services research","volume":"67","author":"Grosse SD","year":"2020","journal-title":"Pediatr Blood Cancer"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70417","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.70417","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:09:54Z","timestamp":1790676594000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.70417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":7,"alternative-id":["10.1111\/trf.70417"],"URL":"https:\/\/doi.org\/10.1111\/trf.70417","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"assertion":[{"value":"2026-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"trf.70417"}}