{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:41:34Z","timestamp":1792557694650,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Newly positive hepatitis B virus (HBV) serologic results after allogeneic hematopoietic cell transplantation (HCT) may reflect passive antibody transfer from blood\u2010derived products rather than HBV infection. We investigated the incidence and temporal patterns of hepatitis B surface antibody (anti\u2010HBs) and antibody to hepatitis B core antibody (anti\u2010HBc) acquisition after allogeneic HCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>We retrospectively evaluated 193 adults who underwent allogeneic HCT for hematologic diseases between May 2012 and March 2025 at a single institution in Japan. Anti\u2010HBs, anti\u2010HBc, and hepatitis B surface antigen (HBsAg) were assessed before and after HCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 180 patients who were anti\u2010HBc negative before HCT, 6 (3.3%) developed anti\u2010HBc positivity after HCT. Among 164 patients who were anti\u2010HBs negative before HCT, 49 (29.9%) developed anti\u2010HBs positivity. All patients with newly detectable antibodies remained HBsAg negative, and available HBV DNA measurements showed no evidence of active HBV infection. Among patients with subsequent follow\u2010up measurements, anti\u2010HBc disappeared in 3 of 3 evaluable patients after a median of 240\u2009days, whereas anti\u2010HBs declined or disappeared in 30 of 32 evaluable patients after a median of 119\u2009days. Among patients receiving neither fresh frozen plasma nor intravenous immunoglobulin, anti\u2010HBs concentrations increased significantly after HCT (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; .0001), with a greater increase among those receiving \u226524 versus \u226423 platelet transfusions (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.0437).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Newly detectable HBV antibodies were common after HCT without virologic evidence of infection, suggesting passive antibody transfer from cellular blood components, particularly platelets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70448","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:22:14Z","timestamp":1792556534000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Passive acquisition of hepatitis B virus antibodies after allogeneic hematopoietic cell transplantation"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1953-8463","authenticated-orcid":false,"given":"Takaaki","family":"Konuma","sequence":"first","affiliation":[{"name":"Department of Hematology\/Oncology The Institute of Medical Science, The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Monna\u2010Oiwa","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology The Institute of Medical Science, The University of Tokyo  Tokyo 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Institute of Medical Science, The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1076-2338","authenticated-orcid":false,"given":"Satoshi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology The Institute of Medical Science, The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhito","family":"Nannya","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology The Institute of Medical Science, The University of Tokyo  Tokyo 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