{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:43:02Z","timestamp":1792662182888,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Therapeutic plasma exchange (TPE) is a procedure done for a broad variety of indications in which plasma proteins, including immunoglobulins, are removed. Current literature evaluating the risk of infection following TPE is limited to small single center studies, specific care contexts, or single indications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a descriptive retrospective cohort study using the TriNetX federated EHR network. Patients who underwent TPE were identified. Those with qualifying infection codes 30\u2009days or 7 days prior to their TPE procedure were excluded. The primary outcome was a composite of \u201cany serious infections\u201d within 30\u2009days of the index TPE, with further analysis of five individual infection types. Opportunistic fungal infections were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 22,993 patients, the composite 30\u2010day proportion of infection following TPE was 6.3% (95% CI, 6.0%\u20136.6%), with the most common infections being sepsis at 2.2% (95% CI, 2.1\u20132.4), pneumonia at 2.0% (95% CI, 1.9\u20132.2), and urinary tract infection at 2.3% (95% CI, 2.1\u20132.5). Findings were consistent in sensitivity analyses using a 7\u2010day washout and by era of index TPE. The opportunistic fungal infection proportion at 30\u2009days was infrequent, 1.1% (95% CI, 1.0\u20131.2). Kaplan\u2013Meier analysis did not show pronounced peri\u2010procedural clustering.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These hypothesis generating findings in a large cohort of over 22,000 patients covering various indications across multiple care settings are roughly consistent with prior literature and indicate further studies with comparator groups are needed to clarify whether TPE independently increases infection risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.70453","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:27:58Z","timestamp":1792661278000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Infection following therapeutic plasma exchange: A large\u2010scale descriptive cohort study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5634-8358","authenticated-orcid":false,"given":"Happy","family":"Xiong","sequence":"first","affiliation":[{"name":"University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5474-1996","authenticated-orcid":false,"given":"Caitlin","family":"Raymond","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Wisconsin Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2022.10.017"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12629"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2011.01026.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-114-11-924"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-024-01346-7"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCE.0000000000000988"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003232.pub4"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41773"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-025-03970-2"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2025.103742"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.70124"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1516126"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2021-064604"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2023.103831"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2025.104132"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70453","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.70453","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.70453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:27:59Z","timestamp":1792661279000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.70453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,22]]},"references-count":15,"alternative-id":["10.1111\/trf.70453"],"URL":"https:\/\/doi.org\/10.1111\/trf.70453","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,22]]},"assertion":[{"value":"2026-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"trf.70453"}}