{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T17:25:22Z","timestamp":1775755522708,"version":"3.50.1"},"reference-count":40,"publisher":"Frontiers Media SA","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"European Society for Organ Transplantation (ESOT)"},{"name":"Fund for Research Flanders (FWO), Belgium","award":["12G8715N"],"award-info":[{"award-number":["12G8715N"]}]},{"name":"Fund for Research Flanders (FWO), Belgium","award":["G.0723.10"],"award-info":[{"award-number":["G.0723.10"]}]},{"name":"Fund for Research Flanders (FWO), Belgium","award":["G.0753.10"],"award-info":[{"award-number":["G.0753.10"]}]},{"name":"Fund for Research Flanders (FWO), Belgium","award":["G.0679.12"],"award-info":[{"award-number":["G.0679.12"]}]},{"name":"Fund for Research Flanders (FWO), Belgium","award":["G.0705.12"],"award-info":[{"award-number":["G.0705.12"]}]},{"name":"Fund for Research Flanders (FWO), Belgium","award":["G.3C04.99"],"award-info":[{"award-number":["G.3C04.99"]}]},{"name":"KU Leuven, Belgium","award":["OT 10\/050"],"award-info":[{"award-number":["OT 10\/050"]}]},{"name":"KU Leuven, Belgium","award":["OT\/11\/079"],"award-info":[{"award-number":["OT\/11\/079"]}]},{"name":"Roche and Astellas"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transpl Int"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1111\/tri.12781","type":"journal-article","created":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T20:26:32Z","timestamp":1459628792000},"page":"715-726","source":"Crossref","is-referenced-by-count":39,"title":["Combined liver-thoracic transplantation: single-center experience with introduction of the<i>\u2018Liver-first\u2019<\/i>principle"],"prefix":"10.3389","volume":"29","author":[{"given":"Laurens J.","family":"Ceulemans","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology; Abdominal Transplant Surgery; University Hospitals Leuven; KU Leuven Belgium"},{"name":"Department of Clinical and Experimental Medicine; Thoracic Surgery; University Hospitals Leuven; KU Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien","family":"Strypstein","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology; Abdominal Transplant Surgery; University Hospitals Leuven; KU Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Neyrinck","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences; Anaesthesiology; University Hospitals Leuven; KU Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stijn","family":"Verleden","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine; Pneumology; University Hospitals Leuven; KU Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Ruttens","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine; Pneumology; University Hospitals Leuven; KU Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diethard","family":"Monbaliu","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology; Abdominal Transplant Surgery; University Hospitals Leuven; KU Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"De Leyn","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine; Thoracic Surgery; University Hospitals Leuven; KU Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Vanhaecke","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences; Cardiology; University Hospitals Leuven; KU Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart","family":"Meyns","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences; Cardiac Surgery; University Hospitals Leuven; KU Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederik","family":"Nevens","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine; Hepatology; University Hospitals Leuven; KU Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geert","family":"Verleden","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine; Pneumology; University Hospitals Leuven; KU Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Van Raemdonck","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine; Thoracic Surgery; University Hospitals Leuven; KU Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Pirenne","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology; Abdominal Transplant Surgery; University Hospitals Leuven; KU Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2016,4,28]]},"reference":[{"key":"10.1111\/tri.12781-BIB0001|tri12781-cit-0001","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1111\/ajt.12291","article-title":"Simultaneous thoracic and abdominal transplantation: can we justify two organs for one recipient?","volume":"13","author":"Wolf","year":"2013","journal-title":"Am J Transplant"},{"key":"10.1111\/tri.12781-BIB0002|tri12781-cit-0002","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1111\/j.1432-2277.2012.01551.x","article-title":"A review of the United States experience with combined heart-liver transplantation","volume":"25","author":"Cannon","year":"2012","journal-title":"Transpl Int"},{"key":"10.1111\/tri.12781-BIB0003|tri12781-cit-0003","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/tri.12549","article-title":"Combined heart-liver transplantation: a single-center experience","volume":"28","author":"Careddu","year":"2015","journal-title":"Transpl Int"},{"key":"10.1111\/tri.12781-BIB0004|tri12781-cit-0004","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/00007890-200201150-00025","article-title":"Combined liver and (heart-)lung transplantation in liver transplant candidates with refractory portopulmonary hypertension","volume":"73","author":"Pirenne","year":"2002","journal-title":"Transplantation"},{"key":"10.1111\/tri.12781-BIB0005|tri12781-cit-0005","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1399-3046.2010.01460.x","article-title":"Liver and combined lung and liver transplantation for cystic fibrosis: analysis of the UNOS database","volume":"15","author":"Arnon","year":"2011","journal-title":"Pediatr Transplant"},{"key":"10.1111\/tri.12781-BIB0006|tri12781-cit-0006","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1111\/ajt.12856","article-title":"Combined Liver and lung transplantation with extended normothermic lung preservation in a patient with end-stage emphysema complicated by drug-induced acute liver\u00a0failure","volume":"14","author":"Ceulemans","year":"2014","journal-title":"Am J Transplant"},{"key":"10.1111\/tri.12781-BIB0007|tri12781-cit-0007","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1183\/09031936.00107514","article-title":"An international ISHLT\/ATS\/ERS clinical practice guideline: diagnosis and management of bronchiolitis obliterans syndrome","volume":"44","author":"Meyer","year":"2014","journal-title":"Eur Respir J"},{"key":"10.1111\/tri.12781-BIB0008|tri12781-cit-0008","unstructured":"Eurotransplant data registry https:\/\/www.eurotransplant.org\/cms\/index.php?page=registry1"},{"key":"10.1111\/tri.12781-BIB0009|tri12781-cit-0009","unstructured":"Organ Procurement and Transplantation Network (OPTN) http:\/\/optn.transplant.hrsa.gov\/"},{"key":"10.1111\/tri.12781-BIB0010|tri12781-cit-0010","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/ajt.12595","article-title":"Combined heart-liver transplantation in the MELD era: do waitlisted patients require exception status?","volume":"14","author":"Schaffer","year":"2014","journal-title":"Am J Transplant"},{"key":"10.1111\/tri.12781-BIB0011|tri12781-cit-0011","unstructured":"Eurotransplant (ET) https:\/\/www.eurotransplant.org\/cms\/"},{"key":"10.1111\/tri.12781-BIB0012|tri12781-cit-0012","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1002\/lt.23957","article-title":"Reframing the impact of combined heart-liver allocation on liver transplant waitlist candidates","volume":"20","author":"Goldberg","year":"2014","journal-title":"Liver Transpl"},{"key":"10.1111\/tri.12781-BIB0013|tri12781-cit-0013","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S0022-5223(95)70064-1","article-title":"Combined lung and liver transplantation in patients with cystic fibrosis. A 4 1\/2-year experience","volume":"110","author":"Couetil","year":"1995","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1111\/tri.12781-BIB0014|tri12781-cit-0014","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/S0140-6736(01)06003-2","article-title":"Combined transplantation of the heart, lung, and liver","volume":"358","author":"Praseedom","year":"2001","journal-title":"Lancet"},{"key":"10.1111\/tri.12781-BIB0015|tri12781-cit-0015","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1097\/01.tp.0000165717.23652.09","article-title":"Combined lung and liver transplantation: the United States experience","volume":"80","author":"Barshes","year":"2005","journal-title":"Transplantation"},{"key":"10.1111\/tri.12781-BIB0016|tri12781-cit-0016","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.healun.2008.04.004","article-title":"Current state of combined heart-liver transplantation in the United States","volume":"27","author":"Te","year":"2008","journal-title":"J Heart Lung Transplant"},{"key":"10.1111\/tri.12781-BIB0017|tri12781-cit-0017","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1097\/TP.0b013e3181636f3f","article-title":"Indications for and outcomes after combined lung and liver transplantation: a single-center experience on 13 consecutive cases","volume":"85","author":"Grannas","year":"2008","journal-title":"Transplantation"},{"key":"10.1111\/tri.12781-BIB0018|tri12781-cit-0018","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/TP.0b013e3181ac60db","article-title":"Combined heart and liver transplantation: a single-center experience","volume":"88","author":"Raichlin","year":"2009","journal-title":"Transplantation"},{"key":"10.1111\/tri.12781-BIB0019|tri12781-cit-0019","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/lt.22202","article-title":"Portopulmonary hypertension as an indication for combined heart, lung, and liver or lung and liver transplantation: literature review and case presentation","volume":"17","author":"Scouras","year":"2011","journal-title":"Liver Transpl"},{"key":"10.1111\/tri.12781-BIB0020|tri12781-cit-0020","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.athoracsur.2012.09.010","article-title":"Combined heart and liver transplantation: the Cleveland clinic experience","volume":"95","author":"Nagpal","year":"2013","journal-title":"Ann Thorac Surg"},{"key":"10.1111\/tri.12781-BIB0021|tri12781-cit-0021","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1097\/TP.0b013e31827eef7e","article-title":"Combined heart and liver transplant attenuates cardiac allograft vasculopathy compared with isolated heart transplantation","volume":"95","author":"Topilsky","year":"2013","journal-title":"Transplantation"},{"key":"10.1111\/tri.12781-BIB0022|tri12781-cit-0022","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/TP.0000000000000231","article-title":"The perioperative management of patients undergoing combined heart-liver transplantation","volume":"99","author":"Barbara","year":"2015","journal-title":"Transplantation"},{"key":"10.1111\/tri.12781-BIB0023|tri12781-cit-0023","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.athoracsur.2014.04.100","article-title":"Combined heart and liver transplantation can be safely performed\u00a0with excellent short- and long-term results","volume":"98","author":"Atluri","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"10.1111\/tri.12781-BIB0024|tri12781-cit-0024","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/lt.23770","article-title":"Combined lung and liver transplantation: analysis of a single-center experience","volume":"20","author":"Yi","year":"2014","journal-title":"Liver Transpl"},{"key":"10.1111\/tri.12781-BIB0025|tri12781-cit-0025","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1016\/j.transproceed.2015.07.038","article-title":"Combined heart and liver transplantation: the Cedars-Sinai experience","volume":"47","author":"Reich","year":"2015","journal-title":"Transplant Proc"},{"key":"10.1111\/tri.12781-BIB0026|tri12781-cit-0026","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1111\/ajt.13430","article-title":"Combined\/serial live rand lung transplantation for epithelioid hemangioendothelioma: a case series","volume":"15","author":"Desie","year":"2015","journal-title":"Am J Transplant"},{"key":"10.1111\/tri.12781-BIB0027|tri12781-cit-0027","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/S0140-6736(84)91876-2","article-title":"Heart-liver transplantation in a patient with familial hypercholesterolaemia","volume":"1","author":"Starzl","year":"1984","journal-title":"Lancet"},{"key":"10.1111\/tri.12781-BIB0028|tri12781-cit-0028","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.healun.2013.08.006","article-title":"The registry of the international society for heart and lung transplantation: thirtieth official adult and heart transplant report 2013; focus theme: age","volume":"32","author":"Lund","year":"2013","journal-title":"J Heart Lung Transplant"},{"key":"10.1111\/tri.12781-BIB0029|tri12781-cit-0029","first-page":"192","article-title":"Transplantation of liver, heart, and lungs for primary biliary cirrhosis and primary pulmonary hypertension","volume":"2","author":"Wallwork","year":"1987","journal-title":"Lancet"},{"key":"10.1111\/tri.12781-BIB0030|tri12781-cit-0030","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1056\/NEJM198802113180602","article-title":"Liver disease and common-bile-duct stenosis in cystic fibrosis","volume":"318","author":"Gaskin","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1111\/tri.12781-BIB0031|tri12781-cit-0031","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11894-005-0053-6","article-title":"The gallbladder and biliary tract in cystic fibrosis","volume":"7","author":"Curry","year":"2005","journal-title":"Curr Gastroenterol Rep"},{"key":"10.1111\/tri.12781-BIB0032|tri12781-cit-0032","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1097\/TP.0b013e318277226d","article-title":"Combined heart and liver transplantation: protection of the cardiac graft from antibody rejection by initial liver implantation","volume":"95","author":"Daly","year":"2013","journal-title":"Transplantation"},{"key":"10.1111\/tri.12781-BIB0033|tri12781-cit-0033","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1097\/TP.0b013e31818b2316","article-title":"Prolonged cold ischemic time is a risk factor for biliary strictures in duct-to-duct biliary reconstruction in living donor liver transplantation","volume":"86","author":"Park","year":"2008","journal-title":"Transplantation"},{"key":"10.1111\/tri.12781-BIB0034|tri12781-cit-0034","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1097\/SLA.0b013e31817fc2b8","article-title":"The combined organ effect: protection against injury?","volume":"248","author":"Rana","year":"2008","journal-title":"Ann Surg"},{"key":"10.1111\/tri.12781-BIB0035|tri12781-cit-0035","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1016\/j.healun.2005.03.015","article-title":"Multi-organ transplantation: is there a protective effect against acute and chronic rejection?","volume":"24","author":"Pinderski","year":"2005","journal-title":"J Heart Lung Transplant"},{"key":"10.1111\/tri.12781-BIB0036|tri12781-cit-0036","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/223472a0","article-title":"Induction of immunological tolerance by porcine liver allografts","volume":"223","author":"Calne","year":"1969","journal-title":"Nature"},{"key":"10.1111\/tri.12781-BIB0037|tri12781-cit-0037","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/00007890-199008000-00027","article-title":"Specific absorption of lymphocytotoxic\u00a0alloantibodies by the liver in inbred rats","volume":"50","author":"Gugenheim","year":"1990","journal-title":"Transplantation"},{"key":"10.1111\/tri.12781-BIB0038|tri12781-cit-0038","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1600-6143.2006.01592.x","article-title":"Successful combined partial auxiliary liver and kidney transplantation in highly sensitized cross-match positive recipients","volume":"7","author":"Olausson","year":"2007","journal-title":"Am J Transplant"},{"key":"10.1111\/tri.12781-BIB0039|tri12781-cit-0039","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1097\/00007890-199010000-00029","article-title":"Specific suppression of allograft rejection by\u00a0soluble class I antigen and complexes\u00a0with monoclonal antibody","volume":"50","author":"Sumimoto","year":"1990","journal-title":"Transplantation"},{"key":"10.1111\/tri.12781-BIB0040|tri12781-cit-0040","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1046\/j.1440-1711.2002.01068.x","article-title":"Activation-induced cell death: the controversial role of FAS and FAS ligand in immune privilege and tumour counterattack","volume":"80","author":"Maher","year":"2002","journal-title":"Immunol Cell Biol"}],"container-title":["Transplant International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftri.12781","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/tri.12781\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T18:42:02Z","timestamp":1641062522000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tri.12781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,28]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"URL":"https:\/\/doi.org\/10.1111\/tri.12781","archive":["Portico"],"relation":{},"ISSN":["0934-0874"],"issn-type":[{"value":"0934-0874","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4,28]]}}}