{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:12:53Z","timestamp":1790507573713,"version":"4.1.0"},"reference-count":80,"publisher":"Frontiers Media SA","issue":"8","license":[{"start":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T00:00:00Z","timestamp":1486339200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T00:00:00Z","timestamp":1486339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transpl Int"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1111\/tri.12909","type":"journal-article","created":{"date-parts":[[2016,12,25]],"date-time":"2016-12-25T05:16:58Z","timestamp":1482643018000},"page":"745-753","source":"Crossref","is-referenced-by-count":125,"title":["Treg therapy in transplantation: a general overview"],"prefix":"10.3389","volume":"30","author":[{"given":"Marco","family":"Romano","sequence":"first","affiliation":[{"name":"Immunoregulation Laboratory; Division of Transplantation Immunology & Mucosal Biology; MRC Centre for Transplantation; King's College London; Guy's Hospital; London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sim Lai","family":"Tung","sequence":"additional","affiliation":[{"name":"Immunoregulation Laboratory; Division of Transplantation Immunology & Mucosal Biology; MRC Centre for Transplantation; King's College London; Guy's Hospital; London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley Ann","family":"Smyth","sequence":"additional","affiliation":[{"name":"Immunoregulation Laboratory; Division of Transplantation Immunology & Mucosal Biology; MRC Centre for Transplantation; King's College London; Guy's Hospital; London UK"},{"name":"School of Health Sport and Bioscience; University of East London; London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Immunoregulation Laboratory; Division of Transplantation Immunology & Mucosal Biology; MRC Centre for Transplantation; King's College London; Guy's Hospital; London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,2,6]]},"reference":[{"issue":"Suppl. 1","key":"10.1111\/tri.12909-BIB0001|tri12909-cit-0001","doi-asserted-by":"crossref","first-page":"i29","DOI":"10.1093\/bja\/aer384","article-title":"Organ transplantation: historical perspective and current practice","volume":"108","author":"Watson","year":"2012","journal-title":"Br J Anaesth"},{"key":"10.1111\/tri.12909-BIB0002|tri12909-cit-0002","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/tri.12553","article-title":"The need for minimization strategies: current problems of immunosuppression","volume":"28","author":"Bamoulid","year":"2015","journal-title":"Transpl Int"},{"key":"10.1111\/tri.12909-BIB0003|tri12909-cit-0003","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.trre.2015.02.005","article-title":"Immunosuppressive therapies after heart transplantation-the balance between under- and over-immunosuppression","volume":"29","author":"S\u00f6derlund","year":"2015","journal-title":"Transplant Rev"},{"key":"10.1111\/tri.12909-BIB0004|tri12909-cit-0004","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.4254\/wjh.v7.i10.1355","article-title":"Review on immunosuppression in liver transplantation","volume":"7","author":"Moini","year":"2015","journal-title":"World J Hepatol"},{"key":"10.1111\/tri.12909-BIB0005|tri12909-cit-0005","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.jhep.2009.03.006","article-title":"Operational tolerance after liver transplantation","volume":"50","author":"Orlando","year":"2009","journal-title":"J Hepatol"},{"issue":"Suppl. 3","key":"10.1111\/tri.12909-BIB0006|tri12909-cit-0006","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1002\/lt.22421","article-title":"Hot-topic debate on tolerance: immunosuppression withdrawal","volume":"17","author":"S\u00e1nchez-Fueyo","year":"2011","journal-title":"Liver Transpl"},{"key":"10.1111\/tri.12909-BIB0007|tri12909-cit-0007","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1002\/hep.26426","article-title":"Prospective multicenter clinical trial of immunosuppressive drug withdrawal in stable adult liver transplant recipients","volume":"58","author":"Ben\u00edtez","year":"2013","journal-title":"Hepatology"},{"key":"10.1111\/tri.12909-BIB0008|tri12909-cit-0008","doi-asserted-by":"crossref","first-page":"6445","DOI":"10.1158\/0008-5472.CAN-16-1311","article-title":"Allogeneic stem cell transplantation: a historical and scientific overview","volume":"76","author":"Singh","year":"2016","journal-title":"Cancer Res"},{"key":"10.1111\/tri.12909-BIB0009|tri12909-cit-0009","doi-asserted-by":"crossref","first-page":"5726132","DOI":"10.1155\/2016\/5726132","article-title":"Review on haploidentical hematopoietic cell transplantation in patients with hematologic malignancies","volume":"2016","author":"Fabricius","year":"2016","journal-title":"Adv Hematol"},{"key":"10.1111\/tri.12909-BIB0010|tri12909-cit-0010","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1586\/ehm.10.21","article-title":"Allogeneic hematopoietic cell transplantation: the state of the art","volume":"3","author":"Gyurkocza","year":"2010","journal-title":"Expert Rev Hematol"},{"key":"10.1111\/tri.12909-BIB0011|tri12909-cit-0011","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nri2000","article-title":"Graft-versus-host disease","volume":"7","author":"Shlomchik","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1111\/tri.12909-BIB0012|tri12909-cit-0012","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1177\/2040620713489842","article-title":"Treatment and management of graft-versus-host disease: improving response and survival","volume":"4","author":"Garnett","year":"2013","journal-title":"Ther Adv Hematol"},{"key":"10.1111\/tri.12909-BIB0013|tri12909-cit-0013","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nri3212","article-title":"Advances in graft-versus-host disease biology and therapy","volume":"12","author":"Blazar","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"10.1111\/tri.12909-BIB0014|tri12909-cit-0014","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.bbmt.2012.04.005","article-title":"First- and second-line systemic treatment of acute graft-versus-host disease: recommendations of the American Society of Blood and Marrow Transplantation","volume":"18","author":"Martin","year":"2012","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1111\/tri.12909-BIB0015|tri12909-cit-0015","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1182\/blood-2014-08-551994","article-title":"How we treat chronic graft-versus-host disease","volume":"125","author":"Flowers","year":"2015","journal-title":"Blood"},{"key":"10.1111\/tri.12909-BIB0016|tri12909-cit-0016","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1002\/eji.200940030","article-title":"Regulatory T cells for the prevention of graft- versus -host disease: professionals defeat amateurs","volume":"39","author":"Edinger","year":"2009","journal-title":"Eur J Immunol"},{"key":"10.1111\/tri.12909-BIB0017|tri12909-cit-0017","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/ajt.12647","article-title":"Harnessing regulatory T cells for clinical use in transplantation: the end of the beginning","volume":"14","author":"Juvet","year":"2014","journal-title":"Am J Transplant"},{"key":"10.1111\/tri.12909-BIB0018|tri12909-cit-0018","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.155.3.1151","article-title":"Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases","volume":"155","author":"Sakaguchi","year":"1995","journal-title":"J Immunol"},{"key":"10.1111\/tri.12909-BIB0019|tri12909-cit-0019","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"10.1111\/tri.12909-BIB0020|tri12909-cit-0020","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ni904","article-title":"Foxp3 programs the development and function of CD4+CD25+ regulatory T cells","volume":"4","author":"Fontenot","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1111\/tri.12909-BIB0021|tri12909-cit-0021","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/nm915","article-title":"CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation","volume":"9","author":"Edinger","year":"2003","journal-title":"Nat Med"},{"key":"10.1111\/tri.12909-BIB0022|tri12909-cit-0022","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1053\/bbmt.2003.50027","article-title":"Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD425 T cells to allow an effective graft-versus-leukemia response","volume":"9","author":"Jones","year":"2003","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1111\/tri.12909-BIB0023|tri12909-cit-0023","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.4049\/jimmunol.176.2.1266","article-title":"Ex vivo-expanded CD4+CD25+ immunoregulatory T cells prevent graft-versus-host-disease by inhibiting activation\/differentiation of pathogenic T cells","volume":"176","author":"Trenado","year":"2006","journal-title":"J Immunol"},{"key":"10.1111\/tri.12909-BIB0024|tri12909-cit-0024","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/nm.2154","article-title":"In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells","volume":"16","author":"Nadig","year":"2010","journal-title":"Nat Med"},{"key":"10.1111\/tri.12909-BIB0025|tri12909-cit-0025","doi-asserted-by":"crossref","first-page":"e90387","DOI":"10.1371\/journal.pone.0090387","article-title":"Ex vivo expanded human regulatory T cells delay islet allograft rejection via inhibiting islet-derived monocyte chemoattractant protein-1 production in CD34+ stem cells-reconstituted NOD-scid IL2r\u03b3null mice","volume":"9","author":"Xiao","year":"2014","journal-title":"PLoS One"},{"key":"10.1111\/tri.12909-BIB0026|tri12909-cit-0026","doi-asserted-by":"crossref","first-page":"83ra42","DOI":"10.1126\/scitranslmed.3002076","article-title":"Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells","volume":"3","author":"Sagoo","year":"2011","journal-title":"Sci Transl Med"},{"key":"10.1111\/tri.12909-BIB0027|tri12909-cit-0027","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3389\/fimmu.2012.00184","article-title":"Relevance of regulatory T cell promotion of donor-specific tolerance in solid organ transplantation","volume":"3","author":"Sagoo","year":"2012","journal-title":"Front Immunol"},{"key":"10.1111\/tri.12909-BIB0028|tri12909-cit-0028","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1097\/01.tp.0000244932.29542.9e","article-title":"Generation and expansion of human CD4+ CD25+ regulatory T cells with indirect allospecificity: potential reagents to promote donor-specific transplantation tolerance","volume":"82","author":"Jiang","year":"2006","journal-title":"Transplantation"},{"key":"10.1111\/tri.12909-BIB0029|tri12909-cit-0029","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.clim.2009.06.001","article-title":"First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127\u2212 T regulatory cells","volume":"133","author":"Trzonkowski","year":"2009","journal-title":"Clin Immunol"},{"key":"10.1111\/tri.12909-BIB0030|tri12909-cit-0030","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/TP.0000000000000243","article-title":"Regulatory T-cell therapy in the induction of transplant tolerance: the issue of subpopulations","volume":"98","author":"Edozie","year":"2014","journal-title":"Transplantation"},{"key":"10.1111\/tri.12909-BIB0031|tri12909-cit-0031","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1097\/MOT.0b013e32834016d1","article-title":"CD8+ regulatory T cells in solid organ transplantation","volume":"15","author":"Guillonneau","year":"2010","journal-title":"Curr Opin Organ Transplant"},{"key":"10.1111\/tri.12909-BIB0032|tri12909-cit-0032","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1084\/jem.193.11.1285","article-title":"Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood","volume":"193","author":"Jonuleit","year":"2001","journal-title":"J Exp Med"},{"key":"10.1111\/tri.12909-BIB0033|tri12909-cit-0033","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1084\/jem.20120914","article-title":"Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells","volume":"209","author":"Weiss","year":"2012","journal-title":"J Exp Med"},{"key":"10.1111\/tri.12909-BIB0034|tri12909-cit-0034","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1084\/jem.20120822","article-title":"Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo","volume":"209","author":"Yadav","year":"2012","journal-title":"J Exp Med"},{"key":"10.1111\/tri.12909-BIB0035|tri12909-cit-0035","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1002\/eji.200839040","article-title":"Neuropilin1 is not a marker of human Foxp3 Treg","volume":"39","author":"Milpied","year":"2009","journal-title":"Eur J Immunol"},{"key":"10.1111\/tri.12909-BIB0036|tri12909-cit-0036","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.4049\/jimmunol.1203473","article-title":"Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus","volume":"190","author":"Toker","year":"2013","journal-title":"J Immunol"},{"key":"10.1111\/tri.12909-BIB0037|tri12909-cit-0037","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1084\/jem.20060772","article-title":"CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells","volume":"203","author":"Liu","year":"2006","journal-title":"J Exp Med"},{"key":"10.1111\/tri.12909-BIB0038|tri12909-cit-0038","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.immuni.2009.03.019","article-title":"Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor","volume":"30","author":"Miyara","year":"2009","journal-title":"Immunity"},{"key":"10.1111\/tri.12909-BIB0039|tri12909-cit-0039","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1034\/j.1600-065X.2001.1820117.x","article-title":"Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells","volume":"182","author":"Weiner","year":"2001","journal-title":"Immunol Rev"},{"key":"10.1111\/tri.12909-BIB0040|tri12909-cit-0040","first-page":"39","article-title":"Tr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications","volume":"380","author":"Roncarolo","year":"2014","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1111\/tri.12909-BIB0041|tri12909-cit-0041","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.0105-2896.2006.00420.x","article-title":"Interleukin-10-secreting type 1 regulatory T cells in rodents and humans","volume":"212","author":"Roncarolo","year":"2006","journal-title":"Immunol Rev"},{"key":"10.1111\/tri.12909-BIB0042|tri12909-cit-0042","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.it.2016.08.012","article-title":"Induced regulatory T cells: their development, stability, and applications","volume":"37","author":"Kanamori","year":"2016","journal-title":"Trends Immunol"},{"key":"10.1111\/tri.12909-BIB0043|tri12909-cit-0043","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1084\/jem.188.2.287","article-title":"CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production","volume":"188","author":"Thornton","year":"1998","journal-title":"J Exp Med"},{"key":"10.1111\/tri.12909-BIB0044|tri12909-cit-0044","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nri2343","article-title":"How regulatory T cells work","volume":"8","author":"Vignali","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1111\/tri.12909-BIB0045|tri12909-cit-0045","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.molmed.2013.03.005","article-title":"CD39 and CD73 in immunity and inflammation","volume":"19","author":"Antonioli","year":"2013","journal-title":"Trends Mol Med"},{"key":"10.1111\/tri.12909-BIB0046|tri12909-cit-0046","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.immuni.2011.03.018","article-title":"Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation","volume":"34","author":"Chaudhry","year":"2011","journal-title":"Immunity"},{"key":"10.1111\/tri.12909-BIB0047|tri12909-cit-0047","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1089\/jir.2015.0015","article-title":"Interleukin-35: expanding its job profile","volume":"35","author":"Sawant","year":"2015","journal-title":"J Interferon Cytokine Res"},{"key":"10.1111\/tri.12909-BIB0048|tri12909-cit-0048","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1600-065X.2007.00565.x","article-title":"\u201cYin-Yang\u201d functions of transforming growth factor-\u03b2 and T regulatory cells in immune regulation","volume":"220","author":"Wan","year":"2007","journal-title":"Immunol Rev"},{"key":"10.1111\/tri.12909-BIB0049|tri12909-cit-0049","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1126\/science.1202947","article-title":"Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4","volume":"332","author":"Qureshi","year":"2011","journal-title":"Science"},{"key":"10.1111\/tri.12909-BIB0050|tri12909-cit-0050","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1002\/eji.201242909","article-title":"CD73 expression on extracellular vesicles derived from CD4+ CD25+ Foxp3+ T cells contributes to their regulatory function","volume":"43","author":"Smyth","year":"2013","journal-title":"Eur J Immunol"},{"key":"10.1111\/tri.12909-BIB0051|tri12909-cit-0051","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.immuni.2014.05.019","article-title":"MicroRNA-containing T-regulatory-cell-derived exosomes suppress pathogenic T helper 1 cells","volume":"41","author":"Okoye","year":"2014","journal-title":"Immunity"},{"key":"10.1111\/tri.12909-BIB0052|tri12909-cit-0052","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cellimm.2013.06.010","article-title":"CD4+CD25+ regulatory T cells-derived exosomes prolonged kidney allograft survival in a rat model","volume":"285","author":"Yu","year":"2013","journal-title":"Cell Immunol"},{"key":"10.1111\/tri.12909-BIB0053|tri12909-cit-0053","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.bbmt.2006.01.005","article-title":"Isolation of CD4+CD25+ regulatory T cells for clinical trials","volume":"12","author":"Hoffmann","year":"2006","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1111\/tri.12909-BIB0054|tri12909-cit-0054","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.transci.2012.06.007","article-title":"T regulatory cell separation for clinical application","volume":"47","author":"Di Ianni","year":"2012","journal-title":"Transfus Apher Sci"},{"key":"10.1111\/tri.12909-BIB0055|tri12909-cit-0055","doi-asserted-by":"crossref","first-page":"7563","DOI":"10.18632\/oncotarget.6927","article-title":"Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation","volume":"7","author":"Safinia","year":"2016","journal-title":"Oncotarget"},{"key":"10.1111\/tri.12909-BIB0056|tri12909-cit-0056","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.2215\/CJN.12931212","article-title":"Comparison of regulatory T cells in hemodialysis patients and healthy controls: implications for cell therapy in transplantation","volume":"8","author":"Afzali","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1111\/tri.12909-BIB0057|tri12909-cit-0057","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1182\/blood-2010-07-293795","article-title":"Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics","volume":"117","author":"Brunstein","year":"2011","journal-title":"Blood"},{"key":"10.1111\/tri.12909-BIB0058|tri12909-cit-0058","doi-asserted-by":"crossref","first-page":"e3161","DOI":"10.1371\/journal.pone.0003161","article-title":"Clinical grade Treg: GMP isolation, improvement of purity by CD127 Depletion, Treg expansion, and Treg cryopreservation","volume":"3","author":"Peters","year":"2008","journal-title":"PLoS One"},{"key":"10.1111\/tri.12909-BIB0059|tri12909-cit-0059","first-page":"79","article-title":"Clinical grade isolation of regulatory T cells from G-CSF mobilized peripheral blood improves with initial depletion of monocytes","volume":"5","author":"Patel","year":"2015","journal-title":"Am J Blood Res"},{"key":"10.1111\/tri.12909-BIB0060|tri12909-cit-0060","doi-asserted-by":"crossref","first-page":"315ra189","DOI":"10.1126\/scitranslmed.aad4134","article-title":"Type 1 diabetes immunotherapy using polyclonal regulatory T cells","volume":"7","author":"Bluestone","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1111\/tri.12909-BIB0061|tri12909-cit-0061","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/MOT.0b013e328355a992","article-title":"Regulatory T-cell therapy for transplantation","volume":"17","author":"Tang","year":"2012","journal-title":"Curr Opin Organ Transplant"},{"key":"10.1111\/tri.12909-BIB0062|tri12909-cit-0062","doi-asserted-by":"crossref","first-page":"e15868","DOI":"10.1371\/journal.pone.0015868","article-title":"Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells","volume":"6","author":"Golovina","year":"2011","journal-title":"PLoS One"},{"key":"10.1111\/tri.12909-BIB0063|tri12909-cit-0063","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.3324\/haematol.2012.074088","article-title":"Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4(+)CD25(+)FOXP3(+) T regulatory cell subpopulations","volume":"98","author":"Scott\u00e0","year":"2013","journal-title":"Haematologica"},{"key":"10.1111\/tri.12909-BIB0064|tri12909-cit-0064","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1097\/01.tp.0000229473.95202.50","article-title":"Calcineurin inhibitors, but not rapamycin, reduce percentages of CD4+CD25+FOXP3+ regulatory T cells in renal transplant recipients","volume":"82","author":"Segundo","year":"2006","journal-title":"Transplantation"},{"key":"10.1111\/tri.12909-BIB0065|tri12909-cit-0065","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nri2546","article-title":"Immunoregulatory functions of mTOR inhibition","volume":"9","author":"Thomson","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"10.1111\/tri.12909-BIB0066|tri12909-cit-0066","doi-asserted-by":"crossref","first-page":"8338","DOI":"10.4049\/jimmunol.177.12.8338","article-title":"Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients","volume":"177","author":"Battaglia","year":"2006","journal-title":"J Immunol"},{"key":"10.1111\/tri.12909-BIB0067|tri12909-cit-0067","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1182\/blood-2007-06-096438","article-title":"Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3\/Stat-5 independent signaling pathway","volume":"111","author":"Elias","year":"2008","journal-title":"Blood"},{"key":"10.1111\/tri.12909-BIB0068|tri12909-cit-0068","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.immuni.2009.03.008","article-title":"Retinoic acid can directly promote TGF-beta-mediated Foxp3(+) Treg cell conversion of naive T cells","volume":"30","author":"Mucida","year":"2009","journal-title":"Immunity"},{"key":"10.1111\/tri.12909-BIB0069|tri12909-cit-0069","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1111\/ajt.12433","article-title":"Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation","volume":"13","author":"Putnam","year":"2013","journal-title":"Am J Transplant"},{"key":"10.1111\/tri.12909-BIB0070|tri12909-cit-0070","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1182\/blood-2014-03-564401","article-title":"HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse","volume":"124","author":"Martelli","year":"2014","journal-title":"Blood"},{"key":"10.1111\/tri.12909-BIB0071|tri12909-cit-0071","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.jcyt.2014.11.005","article-title":"Adoptive transfer of allogeneic regulatory T cells into patients with chronic graft-versus-host disease","volume":"17","author":"Theil","year":"2015","journal-title":"Cytotherapy"},{"key":"10.1111\/tri.12909-BIB0072|tri12909-cit-0072","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fimmu.2014.00016","article-title":"Immunological outcome in haploidentical-HSC transplanted patients treated with IL-10-anergized donor T cells","volume":"5","author":"Bacchetta","year":"2014","journal-title":"Front Immunol"},{"key":"10.1111\/tri.12909-BIB0073|tri12909-cit-0073","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/2047-1440-1-10","article-title":"The ONE study compares cell therapy products in organ transplantation: introduction to a review series on suppressive monocyte-derived cells","volume":"1","author":"Geissler","year":"2012","journal-title":"Transplant Res"},{"key":"10.1111\/tri.12909-BIB0074|tri12909-cit-0074","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/hep.28459","article-title":"A pilot study of operational tolerance with a regulatory T-cell-based cell therapy in living donor liver transplantation","volume":"64","author":"Todo","year":"2016","journal-title":"Hepatology"},{"key":"10.1111\/tri.12909-BIB0075|tri12909-cit-0075","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/ajt.13456","article-title":"Discarded human thymus is a novel source of stable and long-lived therapeutic regulatory T cells","volume":"16","author":"Dijke","year":"2016","journal-title":"Am J Transplant"},{"key":"10.1111\/tri.12909-BIB0076|tri12909-cit-0076","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2016.30","article-title":"Human CD39hi regulatory T cells present stronger stability and function under inflammatory conditions","author":"Gu","year":"2016","journal-title":"Cell Mol Immunol"},{"key":"10.1111\/tri.12909-BIB0077|tri12909-cit-0077","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4049\/jimmunol.1402381","article-title":"Divergent phenotypes of human regulatory T cells expressing the receptors TIGIT and CD226","volume":"195","author":"Fuhrman","year":"2015","journal-title":"J Immunol"},{"key":"10.1111\/tri.12909-BIB0078|tri12909-cit-0078","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3389\/fimmu.2015.00438","article-title":"Regulatory T cells: serious contenders in the promise for immunological tolerance in transpl antation","volume":"6","author":"Safinia","year":"2015","journal-title":"Front Immunol"},{"key":"10.1111\/tri.12909-BIB0079|tri12909-cit-0079","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/ni0908-1001","article-title":"Tolerance can be infectious","volume":"9","author":"Waldmann","year":"2008","journal-title":"Nat Immunol"},{"key":"10.1111\/tri.12909-BIB0080|tri12909-cit-0080","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1084\/jem.20020394","article-title":"Infectious Tolerance","volume":"196","author":"Jonuleit","year":"2002","journal-title":"J Exp Med"}],"container-title":["Transplant International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftri.12909","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/tri.12909\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T12:42:18Z","timestamp":1692621738000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tri.12909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,6]]},"references-count":80,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"URL":"https:\/\/doi.org\/10.1111\/tri.12909","archive":["Portico"],"relation":{},"ISSN":["0934-0874"],"issn-type":[{"value":"0934-0874","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2,6]]}}}