{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:35:44Z","timestamp":1790717744075,"version":"4.1.0"},"reference-count":42,"publisher":"Frontiers Media SA","issue":"8","license":[{"start":{"date-parts":[[2017,6,26]],"date-time":"2017-06-26T00:00:00Z","timestamp":1498435200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,6,26]],"date-time":"2017-06-26T00:00:00Z","timestamp":1498435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Regensburg Center for Interventional Immunology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transpl Int"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1111\/tri.12988","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T22:04:16Z","timestamp":1495577056000},"page":"765-775","source":"Crossref","is-referenced-by-count":26,"title":["MITAP-compliant characterization of human regulatory macrophages"],"prefix":"10.3389","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1199-4210","authenticated-orcid":false,"given":"James A.","family":"Hutchinson","sequence":"first","affiliation":[{"name":"Department of Surgery; University Hospital Regensburg; Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobert","family":"Ahrens","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine; University Hospital Regensburg; Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward K.","family":"Geissler","sequence":"additional","affiliation":[{"name":"Department of Surgery; University Hospital Regensburg; Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,6,26]]},"reference":[{"key":"10.1111\/tri.12988-BIB0001|tri12988-cit-0001","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/ki.2015.50","article-title":"Now or never? The case for cell-based immunosuppression in kidney transplantation","volume":"87","author":"Hutchinson","year":"2015","journal-title":"Kidney Int"},{"key":"10.1111\/tri.12988-BIB0002|tri12988-cit-0002","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1084\/jem.162.5.1409","article-title":"Specific suppression of allograft rejection by trinitrophenyl (TNP)-induced suppressor cells in recipients treated with TNP-haptenated donor alloantigens","volume":"162","author":"Hutchinson","year":"1985","journal-title":"J Exp Med"},{"key":"10.1111\/tri.12988-BIB0003|tri12988-cit-0003","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1126\/science.8094901","article-title":"\u201cInfectious\u201d transplantation tolerance","volume":"259","author":"Qin","year":"1993","journal-title":"Science"},{"key":"10.1111\/tri.12988-BIB0004|tri12988-cit-0004","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/MOT.0b013e328355a979","article-title":"Regulatory macrophages as therapeutic targets and therapeutic agents in solid organ transplantation","volume":"17","author":"Broichhausen","year":"2012","journal-title":"Curr Opin Organ Transplant"},{"key":"10.1111\/tri.12988-BIB0005|tri12988-cit-0005","unstructured":"Regulation (EC) 1394\/2007 on advanced therapy medicinal products and amending Directive 2001\/83\/EC and Regulation No. 726\/2004 2014"},{"key":"10.1111\/tri.12988-BIB0006|tri12988-cit-0006","doi-asserted-by":"crossref","first-page":"304 ps18","DOI":"10.1126\/scitranslmed.aaa7721","article-title":"Hurdles in therapy with regulatory T cells","volume":"7","author":"Trzonkowski","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1111\/tri.12988-BIB0007|tri12988-cit-0007","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1097\/TP.0000000000000788","article-title":"Somatic cell-based therapy","volume":"99","author":"Hutchinson","year":"2015","journal-title":"Transplantation"},{"key":"10.1111\/tri.12988-BIB0008|tri12988-cit-0008","unstructured":"Hutchinson JA Geissler EK Guder A Immunoregulatory cells and methods for their production 2016"},{"key":"10.1111\/tri.12988-BIB0009|tri12988-cit-0009","doi-asserted-by":"crossref","first-page":"e2300","DOI":"10.7717\/peerj.2300","article-title":"Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies","volume":"4","author":"Lord","year":"2016","journal-title":"PeerJ"},{"key":"10.1111\/tri.12988-BIB0010|tri12988-cit-0010","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/ajt.13627","article-title":"The mononuclear phagocyte system in organ transplantation","volume":"16","author":"Ochando","year":"2016","journal-title":"Am J Transplant"},{"key":"10.1111\/tri.12988-BIB0011|tri12988-cit-0011","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1097\/TP.0000000000000739","article-title":"Macrophages in transplantation","volume":"99","author":"Hutchinson","year":"2015","journal-title":"Transplantation"},{"key":"10.1111\/tri.12988-BIB0012|tri12988-cit-0012","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.immuni.2015.05.009","article-title":"DC-SIGN(+) macrophages control the induction of transplantation tolerance","volume":"42","author":"Conde","year":"2015","journal-title":"Immunity"},{"key":"10.1111\/tri.12988-BIB0013|tri12988-cit-0013","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/2047-1440-1-17","article-title":"Alternative approaches to myeloid suppressor cell therapy in transplantation: comparing regulatory macrophages to tolerogenic DCs and MDSCs","volume":"1","author":"Riquelme","year":"2012","journal-title":"Transplant Res"},{"key":"10.1111\/tri.12988-BIB0014|tri12988-cit-0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-immunol-100311-102839","article-title":"Decisions about dendritic cells: past, present, and future","volume":"30","author":"Steinman","year":"2012","journal-title":"Annu Rev Immunol"},{"key":"10.1111\/tri.12988-BIB0015|tri12988-cit-0015","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00430-010-0151-4","article-title":"Subsets, expansion and activation of myeloid-derived suppressor cells","volume":"199","author":"Ribechini","year":"2010","journal-title":"Med Microbiol Immunol"},{"key":"10.1111\/tri.12988-BIB0016|tri12988-cit-0016","doi-asserted-by":"crossref","first-page":"471719","DOI":"10.1155\/2015\/471719","article-title":"Clinical use of tolerogenic dendritic cells-harmonization approach in european collaborative effort","volume":"2015","author":"Ten","year":"2015","journal-title":"Mediators Inflamm"},{"key":"10.1111\/tri.12988-BIB0017|tri12988-cit-0017","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/2047-1440-1-14","article-title":"Human tolerogenic DC-10: perspectives for clinical applications","volume":"1","author":"Amodio","year":"2012","journal-title":"Transplant Res"},{"key":"10.1111\/tri.12988-BIB0018|tri12988-cit-0018","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/2047-1440-1-16","article-title":"Immunoregulatory properties of rapamycin-conditioned monocyte-derived dendritic cells and their role in transplantation","volume":"1","author":"Macedo","year":"2012","journal-title":"Transplant Res"},{"key":"10.1111\/tri.12988-BIB0019|tri12988-cit-0019","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/2047-1440-1-13","article-title":"Cell therapy using tolerogenic dendritic cells in transplantation","volume":"1","author":"Moreau","year":"2012","journal-title":"Transplant Res"},{"key":"10.1111\/tri.12988-BIB0020|tri12988-cit-0020","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1136\/ard.2009.126383","article-title":"Generation and characterisation of therapeutic tolerogenic dendritic cells for rheumatoid arthritis","volume":"69","author":"Harry","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1111\/tri.12988-BIB0021|tri12988-cit-0021","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/mt.2012.168","article-title":"IFN-gamma-induced iNOS expression in mouse regulatory macrophages prolongs allograft survival in fully immunocompetent recipients","volume":"21","author":"Riquelme","year":"2013","journal-title":"Mol Ther"},{"key":"10.1111\/tri.12988-BIB0022|tri12988-cit-0022","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.4049\/jimmunol.1100762","article-title":"Cutting edge: immunological consequences and trafficking of human regulatory macrophages administered to renal transplant recipients","volume":"187","author":"Hutchinson","year":"2011","journal-title":"J Immunol"},{"key":"10.1111\/tri.12988-BIB0023|tri12988-cit-0023","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/978-1-60761-869-0_13","article-title":"Human regulatory macrophages","volume":"677","author":"Hutchinson","year":"2011","journal-title":"Methods Mol Biol"},{"key":"10.1111\/tri.12988-BIB0024|tri12988-cit-0024","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1399-0012.2008.00953.x","article-title":"Administration of donor-derived transplant acceptance-inducing cells to the recipients of renal transplants from deceased donors is technically feasible","volume":"23","author":"Hutchinson","year":"2009","journal-title":"Clin Transplant"},{"key":"10.1111\/tri.12988-BIB0025|tri12988-cit-0025","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1111\/j.1432-2277.2008.00680.x","article-title":"Transplant acceptance-inducing cells as an immune-conditioning therapy in renal transplantation","volume":"21","author":"Hutchinson","year":"2008","journal-title":"Transpl Int"},{"key":"10.1111\/tri.12988-BIB0026|tri12988-cit-0026","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1111\/j.1432-2277.2008.00692.x","article-title":"A cell-based approach to the minimization of immunosuppression in renal transplantation","volume":"21","author":"Hutchinson","year":"2008","journal-title":"Transpl Int"},{"key":"10.1111\/tri.12988-BIB0027|tri12988-cit-0027","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/j.1432-2277.2008.00712.x","article-title":"Preoperative treatment of a presensitized kidney transplant recipient with donor-derived transplant acceptance-inducing cells","volume":"21","author":"Hutchinson","year":"2008","journal-title":"Transpl Int"},{"key":"10.1111\/tri.12988-BIB0028|tri12988-cit-0028","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1111\/trf.12641","article-title":"Clinical management of patients receiving cell-based immunoregulatory therapy","volume":"54","author":"Hutchinson","year":"2014","journal-title":"Transfusion"},{"key":"10.1111\/tri.12988-BIB0029|tri12988-cit-0029","doi-asserted-by":"crossref","first-page":"14026","DOI":"10.1038\/mtm.2014.26","article-title":"In question: the scientific value of preclinical safety pharmacology and toxicology studies with cell-based therapies","volume":"1","author":"Broichhausen","year":"2014","journal-title":"Mol Ther Methods Clin Dev"},{"key":"10.1111\/tri.12988-BIB0030|tri12988-cit-0030","unstructured":"COMMISSION DIRECTIVE 2006\/17\/EC of 8 February 2006 2006"},{"key":"10.1111\/tri.12988-BIB0031|tri12988-cit-0031","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0022-1759(02)00007-8","article-title":"Immunomagnetic separation reagents as markers in electron microscopy","volume":"262","author":"Fisher","year":"2002","journal-title":"J Immunol Methods"},{"key":"10.1111\/tri.12988-BIB0032|tri12988-cit-0032","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/jlb.60.2.214","article-title":"Differential infection of porcine alveolar macrophage subpopulations by nonopsonized Mycobacterium bovis involves CD14 receptors","volume":"60","author":"Khanna","year":"1996","journal-title":"J Leukoc Biol"},{"key":"10.1111\/tri.12988-BIB0033|tri12988-cit-0033","doi-asserted-by":"crossref","first-page":"e188","DOI":"10.1097\/TP.0000000000001652","article-title":"Donor-specific anti-HLA antibodies present in pooled human serum do not prevent development of human mreg_UKR from monocytes in culture","volume":"101","author":"Hutchinson","year":"2017","journal-title":"Transplantation"},{"key":"10.1111\/tri.12988-BIB0034|tri12988-cit-0034","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.coi.2003.11.006","article-title":"MHC class II signaling in antigen-presenting cells","volume":"16","author":"Al-Daccak","year":"2004","journal-title":"Curr Opin Immunol"},{"key":"10.1111\/tri.12988-BIB0035|tri12988-cit-0035","doi-asserted-by":"crossref","DOI":"10.1097\/TP.0000000000001814","article-title":"DHRS9 is a stable marker of human regulatory macrophages","author":"Riquelme","year":"2017","journal-title":"Transplantation"},{"key":"10.1111\/tri.12988-BIB0036|tri12988-cit-0036","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.4049\/jimmunol.1400869","article-title":"Laser ablation-inductively coupled plasma mass spectrometry: an emerging technology for detecting rare cells in tissue sections","volume":"193","author":"Managh","year":"2014","journal-title":"J Immunol"},{"key":"10.1111\/tri.12988-BIB0037|tri12988-cit-0037","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1097\/TP.0000000000001316","article-title":"Regulatory myeloid cells for tolerance-inducing therapy: finding their own identity","volume":"100","author":"Riquelme","year":"2016","journal-title":"Transplantation"},{"key":"10.1111\/tri.12988-BIB0038|tri12988-cit-0038","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/TP.0000000000001078","article-title":"Identity crisis","volume":"100","author":"Turnquist","year":"2016","journal-title":"Transplantation"},{"key":"10.1111\/tri.12988-BIB0039|tri12988-cit-0039","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1097\/TP.0000000000001315","article-title":"Comparative study of the immunoregulatory capacity of in vitro generated tolerogenic dendritic cells, suppressor macrophages, and myeloid-derived suppressor cells","volume":"100","author":"Carretero-Iglesia","year":"2016","journal-title":"Transplantation"},{"key":"10.1111\/tri.12988-BIB0040|tri12988-cit-0040","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/TP.0b013e3182a860de","article-title":"Regulatory myeloid cells in transplantation","volume":"97","author":"Rosborough","year":"2014","journal-title":"Transplantation"},{"key":"10.1111\/tri.12988-BIB0041|tri12988-cit-0041","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1097\/TP.0000000000000693","article-title":"Minimum information standards","volume":"99","author":"Hutchinson","year":"2015","journal-title":"Transplantation"},{"key":"10.1111\/tri.12988-BIB0042|tri12988-cit-0042","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/TP.0000000000000701","article-title":"Data sharing","volume":"99","author":"Hutchinson","year":"2015","journal-title":"Transplantation"}],"container-title":["Transplant International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftri.12988","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/tri.12988\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T19:28:21Z","timestamp":1750274901000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tri.12988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,26]]},"references-count":42,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"URL":"https:\/\/doi.org\/10.1111\/tri.12988","archive":["Portico"],"relation":{},"ISSN":["0934-0874"],"issn-type":[{"value":"0934-0874","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6,26]]}}}