{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:39:09Z","timestamp":1790365149829,"version":"4.1.0"},"reference-count":92,"publisher":"Frontiers Media SA","issue":"8","license":[{"start":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T00:00:00Z","timestamp":1557187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T00:00:00Z","timestamp":1557187200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transpl Int"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1111\/tri.13436","type":"journal-article","created":{"date-parts":[[2019,4,7]],"date-time":"2019-04-07T16:04:15Z","timestamp":1554653055000},"page":"775-788","source":"Crossref","is-referenced-by-count":105,"title":["The therapeutic challenge of late antibody\u2010mediated kidney allograft rejection"],"prefix":"10.3389","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7600-912X","authenticated-orcid":false,"given":"Georg A.","family":"B\u00f6hmig","sequence":"first","affiliation":[{"name":"Division of Nephrology and Dialysis Department of Medicine III Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farsad","family":"Eskandary","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Dialysis Department of Medicine III Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Doberer","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Dialysis Department of Medicine III Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip F.","family":"Halloran","sequence":"additional","affiliation":[{"name":"Alberta Transplant Applied Genomics Centre (ATAGC) University of Alberta Edmonton AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,5,7]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"2580","article-title":"Antibody\u2010mediated rejection of solid\u2010organ allografts","volume":"379","author":"Lefaucheur C","year":"2018","journal-title":"N Engl J Med"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017121296"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017030287"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14393"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15177"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14939"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2015.02.004"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13115"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001586"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.08.027"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-018-0071-x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002267"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e32835d4daf"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13168"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15175"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14001"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14528"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.00072.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12590"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14625"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14329"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.94197"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03840.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13551"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001195"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016070797"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13347"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2002.21015.x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09901014"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.166"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1302506"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.02104.x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002049"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017070818"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14520"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181a6bac5"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181880b35"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2012.01544.x"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000000746"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2016.01.018"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12535"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-018-1057-4"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.502"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.5892"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02461.x"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318190af83"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181a4b91b"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318218e901"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr465"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13050"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016070727"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15067"},{"key":"e_1_2_9_54_1","unstructured":"NIH U.S. National Library of Medicine.Bortezomib in Rejection of Kidney Transplants (TRIBUTE). Available from:https:\/\/clinicaltrials.gov\/show\/record\/NCT02201576. Published July 28 2014. Updated September 5 2018."},{"key":"e_1_2_9_55_1","unstructured":"NIH U.S. National Library of Medicine.Comparison Between Bortezomib and Rituximab Plus Plasmapheresis in AMR. Available from:https:\/\/clinicaltrials.gov\/show\/record\/NCT03737136. Published November 9 2018."},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14222"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03757.x"},{"key":"e_1_2_9_58_1","unstructured":"NIH U.S. National Library of Medicine.Safety & Efficacy of Eculizumab to Prevent AMR in Living Donor Kidney Transplant Recipients Requiring Desensitization. Available from:https:\/\/clinicaltrials.gov\/show\/results\/NCT01399593. Published July 22 2011. Updated October 3 2017."},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001804"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000995"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13871"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13663"},{"key":"e_1_2_9_63_1","unstructured":"NIH U.S. National Library of Medicine.Efficacy and Safety of Human Plasma\u2010derived C1\u2010esterase Inhibitor as add\u2010on to Standard of Care for the Treatment of Refractory Antibody Mediated Rejection (AMR) in Adult Renal Transplant Recipients. Available from:https:\/\/ClinicalTrials.gov\/show\/NCT03221842. Published July 19 2017. Updated December 10 2018."},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.13103"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001452"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14228"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39249"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39700"},{"key":"e_1_2_9_69_1","unstructured":"NIH U.S. National Library of Medicine.A Pilot Trial of Clazakizumab in Late ABMR. Available from:https:\/\/ClinicalTrials.gov\/show\/NCT03444103. Published February 23 2018."},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-018-3158-6"},{"key":"e_1_2_9_71_1","unstructured":"NIH U.S. National Library of Medicine.Clazakizumab for Chronic and Active Antibody Mediated Rejection Post\u2010Kidney Transplant. Available from: Available from:https:\/\/ClinicalTrials.gov\/show\/NCT03380377. Published December 21 2017. Updated February 28 2018."},{"key":"e_1_2_9_72_1","unstructured":"NIH U.S. National Library of Medicine.Interleukin 6 Blockade Modifying Antibody\u2010Mediated Graft Injury and Estimated Glomerular Filtration Rate (eGFR) Decline (IMAGINE). Available from:https:\/\/ClinicalTrials.gov\/show\/NCT03744910. Published November 19 2018. Updated December 18 2018."},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12160"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61354-2"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30984-X"},{"key":"e_1_2_9_76_1","unstructured":"NIH U.S. National Library of Medicine.Belimumab Impacting Transplant Eligibility. Available from:https:\/\/clinicaltrials.gov\/show\/NCT02500251. Published July 16 2015. Updated August 8 2018."},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606038"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-06-740944"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-3117"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1807438"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2017-0616"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01613.x"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft502"},{"key":"e_1_2_9_84_1","unstructured":"NIH U.S. National Library of Medicine.Treatment of Chronic Active Antibody Mediated Rejection After Kidney Transplantation by Double\u2010Filtration PlasmaPheresis or Plasma Exchange (DFPP). Available from:https:\/\/clinicaltrials.gov\/show\/NCT03436134. Published February 16 2018."},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.128"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1612567"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002924"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132011"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501929"},{"key":"e_1_2_9_90_1","unstructured":"NIH U.S. National Library of Medicine.Treatment of Chronic Antibody\u2010mediated Rejection in Kidney Transplant With Acthar. Available from: Published September 11 2015. Updated December 10 2018."},{"key":"e_1_2_9_91_1","unstructured":"NIH U.S. National Library of Medicine.Mesenchymal Stem Cell Transplantation in the Treatment of Chronic ABMR. Available from: Published July 13 2018. Updated July 13 2018."},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-15-107"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15088"}],"container-title":["Transplant International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tri.13436","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tri.13436","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tri.13436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T18:41:10Z","timestamp":1641062470000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tri.13436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,7]]},"references-count":92,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/tri.13436"],"URL":"https:\/\/doi.org\/10.1111\/tri.13436","archive":["Portico"],"relation":{},"ISSN":["0934-0874","1432-2277"],"issn-type":[{"value":"0934-0874","type":"print"},{"value":"1432-2277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,7]]}}}