{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:48:40Z","timestamp":1790210920884,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["vaajournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Anaesthesia and Analgesia"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1111\/vaa.12086","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T21:48:41Z","timestamp":1381528121000},"page":"97-104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Electrocardiographic evaluation of the degree of sedation and the isolated use of methadone in healthy dogs"],"prefix":"10.1016","volume":"41","author":[{"given":"Thais M","family":"Menegheti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana T","family":"Wagatsuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ac\u00e1cio D","family":"Pacheco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynara M","family":"Pacheco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio JX","family":"Abimussi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo PS","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria NL","family":"de Souza Oliva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/vaa.12086_bib1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1467-2995.2010.00528.x","article-title":"Effects of methadone on the minimum alveolar concentration of isoflurane in dogs","volume":"37","author":"Credie","year":"2010","journal-title":"Vet Anaesth Analg"},{"key":"10.1111\/vaa.12086_bib2","series-title":"Anestesia Em C\u00e3es e Gatos","first-page":"632","author":"Fantoni","year":"2010"},{"key":"10.1111\/vaa.12086_bib3","series-title":"Semiologia veterin\u00e1ria: A arte do diagn\u00f3stico","author":"Feitosa","year":"2004"},{"key":"10.1111\/vaa.12086_bib4","series-title":"Altera\u00e7\u00f5es Hemodin\u00e2micas e Neuroend\u00f3crinas Associadas ao uso da Metadona em C\u00e3es Conscientes e Anestesiados com Isoflurano. 110f. Disserta\u00e7\u00e3o (Mestrado em Anestesiologia)","author":"Garofalo","year":"2010"},{"key":"10.1111\/vaa.12086_bib5","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1136\/vr.129.10.213","article-title":"Ambulatory electrocardiography in dogs","volume":"129","author":"Hall","year":"1991","journal-title":"Vet Rec"},{"key":"10.1111\/vaa.12086_bib6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0022-3565(25)23653-9","article-title":"Plasma arginine vasopressin response to intravenous methadone and naloxone in conscious dogs","volume":"248","author":"Hellebrekers","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1111\/vaa.12086_bib7","series-title":"Lumb & Jones\u2019 Veterinary Anesthesia and Analgesia","first-page":"31","article-title":"Pain and Its Management","author":"Hellyer","year":"2007"},{"key":"10.1111\/vaa.12086_bib8","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1467-2995.2009.00476.x","article-title":"Clinical pharmacology of methadone in dogs","volume":"37","author":"Ingvast-Larsson","year":"2010","journal-title":"Vet Anaesth Analg"},{"key":"10.1111\/vaa.12086_bib9","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1126\/science.272.5262.681","article-title":"Molecular genetic insights into cardiovascular disease","volume":"272","author":"Keating","year":"1996","journal-title":"Science"},{"key":"10.1111\/vaa.12086_bib10","doi-asserted-by":"crossref","first-page":"387","DOI":"10.7326\/0003-4819-150-6-200903170-00103","article-title":"QTc interval screening in methadone treatment","volume":"150","author":"Krantz","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1111\/vaa.12086_bib11","series-title":"Lumb & Jones\u2019 Veterinary Anesthesia and Analgesia","first-page":"241","article-title":"Opioids, Nonsteroidal Anti-inflammatories and Analgesic Adjuvants","author":"Lamont","year":"2007"},{"key":"10.1111\/vaa.12086_bib12","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1467-2995.2005.00239.x","article-title":"A comparison of extradural and intravenous methadone on intraoperative isoflurane and postoperative analgesia requirements in dogs","volume":"33","author":"Leibetseder","year":"2006","journal-title":"Vet Anaesth Analg"},{"key":"10.1111\/vaa.12086_bib13","series-title":"Lumb & Jones\u2019 Veterinary Anesthesia and Analgesia","first-page":"203","article-title":"Anticholinergics and Sedatives","author":"Lemke","year":"2007"},{"key":"10.1111\/vaa.12086_bib14","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1365-2885.2008.01042.x","article-title":"Comparison of the cardiorespiratory effects of methadone and morphine in conscious dogs","volume":"32","author":"Maiante","year":"2008","journal-title":"J Vet Pharmacol Ther"},{"key":"10.1111\/vaa.12086_bib15","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1467-2995.2008.00412.x","article-title":"Effects of methadone, alone or in combination with acepromazine or xylazine, on sedation and physiologic values in dogs","volume":"35","author":"Monteiro","year":"2008","journal-title":"Vet Anaesth Analg"},{"key":"10.1111\/vaa.12086_bib16","series-title":"Dor: Avalia\u00e7\u00e3o e Tratamento em Pequenos Animais","first-page":"96","article-title":"Drogas analg\u00e9sicas","author":"Otero","year":"2005"},{"key":"10.1111\/vaa.12086_bib17","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0195-5616(08)70005-6","article-title":"Opioid analgesics","volume":"30","author":"Pascoe","year":"2000","journal-title":"Vet Clin N Am: Small Anim"},{"key":"10.1111\/vaa.12086_bib18","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/BF03006849","article-title":"Haemodynamic effects of intravenous methadone anaesthesia in dogs","volume":"27","author":"Stanley","year":"1980","journal-title":"Can J Anaesth"},{"key":"10.1111\/vaa.12086_bib19","series-title":"Essentials of Canine and Feline Electrocardiography: Interpretation and Treatment","author":"Tilley","year":"1992"},{"key":"10.1111\/vaa.12086_bib20","series-title":"Eletrocardiografia Para o Cl\u00ednico de Pequenos Animais","first-page":"112","author":"Tilley","year":"2004"},{"key":"10.1111\/vaa.12086_bib21","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1126\/science.7604285","article-title":"hERG, a human inward rectifier in the voltage-gated potassium channel family","volume":"269","author":"Trudeau","year":"1995","journal-title":"Science"},{"key":"10.1111\/vaa.12086_bib22","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2460\/ajvr.1995.56.03.275","article-title":"Arrhythmia prevalence during ambulatory electrocardiographic monitoring of Beagles","volume":"56","author":"Ulloa","year":"1995","journal-title":"Am J Vet Res"},{"key":"10.1111\/vaa.12086_bib23","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1467-2995.2004.00128.x","article-title":"Effects of acepromazine on the incidence of vomiting associated with opioid administration in dogs","volume":"31","author":"Valverde","year":"2004","journal-title":"Vet Anaesth Analg"}],"container-title":["Veterinary Anaesthesia and Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298716301611?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298716301611?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T02:50:20Z","timestamp":1761447020000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1467298716301611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S1467298716301611"],"URL":"https:\/\/doi.org\/10.1111\/vaa.12086","relation":{},"ISSN":["1467-2987"],"issn-type":[{"value":"1467-2987","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Electrocardiographic evaluation of the degree of sedation and the isolated use of methadone in healthy dogs","name":"articletitle","label":"Article Title"},{"value":"Veterinary Anaesthesia and Analgesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/vaa.12086","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}