{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:18:24Z","timestamp":1791451104774,"version":"4.3.3"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"UVV (University of Vila Velha)"},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["vaajournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Anaesthesia and Analgesia"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1111\/vaa.12265","type":"journal-article","created":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T03:51:15Z","timestamp":1429156275000},"page":"27-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Effects of acepromazine-morphine and acepromazine-methadone premedication on the minimum alveolar concentration of isoflurane in dogs"],"prefix":"10.1016","volume":"43","author":[{"given":"Eduardo R","family":"Monteiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais F","family":"Bressan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa R","family":"Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bet\u00e2nia S","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/vaa.12265_bib1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.tvjl.2010.05.029","article-title":"Reduction of the minimum alveolar concentration of isoflurane in dogs using a constant rate of infusion of lidocaine-ketamine in combination with either morphine or fentanyl","volume":"189","author":"Aguado","year":"2011","journal-title":"Vet J"},{"key":"10.1111\/vaa.12265_bib2","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1467-2995.2010.00528.x","article-title":"Effects of methadone on the minimum alveolar concentration of isoflurane in dogs","volume":"37","author":"Credie","year":"2010","journal-title":"Vet Anaesth Analg"},{"key":"10.1111\/vaa.12265_bib3","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1080\/01621459.1965.10480843","article-title":"The up-and-down method for small samples","volume":"60","author":"Dixon","year":"1965","journal-title":"J Am Stat Assoc"},{"key":"10.1111\/vaa.12265_bib4","doi-asserted-by":"crossref","first-page":"116","DOI":"10.2460\/ajvr.1994.55.01.116","article-title":"Effect of medetomidine on the pharmacokinetics of propofol in dogs","volume":"55","author":"Hall","year":"1994","journal-title":"Am J Vet Res"},{"key":"10.1111\/vaa.12265_bib5","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1097\/00000542-200606000-00011","article-title":"Interaction of propofol and sevoflurane on loss of consciousness and movement to skin incision during general anesthesia","volume":"104","author":"Harris","year":"2006","journal-title":"Anesthesiology"},{"key":"10.1111\/vaa.12265_bib6","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.2460\/ajvr.1986.47.10.2113","article-title":"Effect of acepromazine on the anesthetic requirement of halothane in the dog","volume":"47","author":"Heard","year":"1986","journal-title":"Am J Vet Res"},{"key":"10.1111\/vaa.12265_bib7","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2460\/ajvr.2001.62.555","article-title":"Effects of diazepam and flumazenil on minimum alveolar concentrations for dogs anesthetized with isoflurane or a combination of isoflurane and fentanyl","volume":"62","author":"Hellyer","year":"2001","journal-title":"Am J Vet Res"},{"key":"10.1111\/vaa.12265_bib8","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4102\/jsava.v80i1.161","article-title":"Computer simulations of propofol infusions for total intravenous anaesthesia in dogs","volume":"80","author":"Joubert","year":"2009","journal-title":"J S Afr Vet Assoc"},{"key":"10.1111\/vaa.12265_bib9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.5326\/0450019","article-title":"Effects of carprofen and morphine on the minimum alveolar concentration of isoflurane in dogs","volume":"45","author":"Ko","year":"2009","journal-title":"J Am Anim Hosp Assoc"},{"key":"10.1111\/vaa.12265_bib10","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0014-2999(79)90292-9","article-title":"Vagal bradycardia produced by microinjections of morphine-like drugs into the nucleus ambiguus in anaesthetized dogs","volume":"59","author":"Laubie","year":"1979","journal-title":"Eur J Pharmacol"},{"key":"10.1111\/vaa.12265_bib11","doi-asserted-by":"crossref","first-page":"996","DOI":"10.2460\/ajvr.1983.44.06.996","article-title":"Blood pressure response to phenylephrine infusion in halothane-anesthetized dogs given acetylpromazine maleate","volume":"44","author":"Ludders","year":"1983","journal-title":"Am J Vet Res"},{"key":"10.1111\/vaa.12265_bib12","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.jclinane.2010.02.006","article-title":"Effects of propofol on the minimum alveolar concentration of sevoflurane for immobility at skin incision in adult patients","volume":"22","author":"Luo","year":"2010","journal-title":"J Clin Anesth"},{"key":"10.1111\/vaa.12265_bib13","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1097\/00000542-199604000-00014","article-title":"Anesthetic potency of remifentanil in dogs","volume":"84","author":"Michelsen","year":"1996","journal-title":"Anesthesiology"},{"key":"10.1111\/vaa.12265_bib14","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12929-014-0062-6","article-title":"Isobolographic analysis of the opioid-opioid interactions in a tonic and a phasic mouse model of induced nociceptive pain","volume":"21","author":"Miranda","year":"2014","journal-title":"J Biomed Sci"},{"key":"10.1111\/vaa.12265_bib15","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1467-2995.2008.00412.x","article-title":"Effects of methadone, alone or in combination with acepromazine or xylazine, on sedation and physiologic values in dogs","volume":"35","author":"Monteiro","year":"2008","journal-title":"Vet Anaesth Analg"},{"key":"10.1111\/vaa.12265_bib16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1467-2995.2008.00424.x","article-title":"Comparative study on the sedative effects of morphine, methadone, butorphanol or tramadol, in combination with acepromazine, in dogs","volume":"36","author":"Monteiro","year":"2009","journal-title":"Vet Anaesth Analg"},{"key":"10.1111\/vaa.12265_bib17","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/00000542-198212000-00010","article-title":"The enflurane sparing effect of morphine, butorphanol, and nalbuphine","volume":"57","author":"Murphy","year":"1982","journal-title":"Anesthesiology"},{"key":"10.1111\/vaa.12265_bib18","doi-asserted-by":"crossref","first-page":"885","DOI":"10.2460\/ajvr.1997.58.08.885","article-title":"Cardiopulmonary effects of sevoflurane, compared with halothane, enflurane, and isoflurane, in dogs","volume":"58","author":"Mutoh","year":"1997","journal-title":"Am J Vet Res"},{"key":"10.1111\/vaa.12265_bib19","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1097\/00000542-200112000-00014","article-title":"Are estimates of MAC reliable?","volume":"95","author":"Paul","year":"2001","journal-title":"Anesthesiology"},{"key":"10.1111\/vaa.12265_bib20","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1124\/jpet.105.094276","article-title":"Comparison of the antinociceptive response to morphine and morphine-like compounds in male and female Sprague-Dawley rats","volume":"316","author":"Peckham","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1111\/vaa.12265_bib21","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/00000542-198010000-00008","article-title":"Determination and applications of MAC","volume":"53","author":"Quasha","year":"1980","journal-title":"Anesthesiology"},{"key":"10.1111\/vaa.12265_bib22","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1365-2885.1995.tb00599.x","article-title":"Atipamezole increases medetomidine clearance in the dog: an agonist-antagonist interaction","volume":"18","author":"Salonen","year":"1995","journal-title":"J Vet Pharmacol Ther"},{"key":"10.1111\/vaa.12265_bib23","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.1467-2995.2008.00417.x","article-title":"A comparison of the effects of propofol and etomidate on the induction of anesthesia and on cardiopulmonary parameters in dogs","volume":"35","author":"Sams","year":"2008","journal-title":"Vet Anaesth Analg"},{"key":"10.1111\/vaa.12265_bib24","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/BF02832254","article-title":"Accuracy of expiratory carbon dioxide measurements using the coaxial and circle breathing circuits in small subjects","volume":"1","author":"Schieber","year":"1985","journal-title":"J Clin Monit"},{"key":"10.1111\/vaa.12265_bib25","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1213\/00000539-200209000-00021","article-title":"Issues in the design and interpretation of minimum alveolar anesthetic concentration (MAC) studies","volume":"95","author":"Sonner","year":"2002","journal-title":"Anesth Analg"},{"key":"10.1111\/vaa.12265_bib26","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1213\/01.ANE.0000139353.97950.FA","article-title":"Thiopental produces immobility primarily by supraspinal actions in rats","volume":"100","author":"Stabernack","year":"2005","journal-title":"Anesth Analg"},{"key":"10.1111\/vaa.12265_bib27","series-title":"Lumb and Jones Veterinary Anesthesia and Analgesia","first-page":"355","article-title":"Inhalation Anesthetics","author":"Steffey","year":"2007"},{"key":"10.1111\/vaa.12265_bib28","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1093\/bja\/48.10.947","article-title":"Effect of arterial hypotension on anaesthetic requirement in dogs","volume":"48","author":"Tanifuji","year":"1976","journal-title":"Br J Anaesth"},{"key":"10.1111\/vaa.12265_bib29","doi-asserted-by":"crossref","first-page":"969","DOI":"10.2460\/ajvr.2002.63.969","article-title":"Evaluation of the perioperative stress response in dogs administered medetomidine or acepromazine as part of the preanesthetic medication","volume":"63","author":"V\u00e5is\u00e5nen","year":"2002","journal-title":"Am J Vet Res"},{"key":"10.1111\/vaa.12265_bib30","doi-asserted-by":"crossref","first-page":"957","DOI":"10.2460\/ajvr.2003.64.957","article-title":"Validation of several types of noxious stimuli for use in determining the minimum alveolar concentration for inhalation anesthetics in dogs and rabbits","volume":"64","author":"Valverde","year":"2003","journal-title":"Am J Vet Res"},{"key":"10.1111\/vaa.12265_bib31","first-page":"609","article-title":"The effect of acepromazine maleate on the anesthetic potency of halothane and isoflurane","volume":"24","author":"Webb","year":"1988","journal-title":"J Am Anim Hosp Assoc"}],"container-title":["Veterinary Anaesthesia and Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298716300344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298716300344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T02:49:32Z","timestamp":1761446972000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1467298716300344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S1467298716300344"],"URL":"https:\/\/doi.org\/10.1111\/vaa.12265","relation":{},"ISSN":["1467-2987"],"issn-type":[{"value":"1467-2987","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of acepromazine-morphine and acepromazine-methadone premedication on the minimum alveolar concentration of isoflurane in dogs","name":"articletitle","label":"Article Title"},{"value":"Veterinary Anaesthesia and Analgesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/vaa.12265","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}