{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:30:21Z","timestamp":1761863421262,"version":"build-2065373602"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100015900","name":"Ontario Veterinary College Pet Trust Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015900","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["vaajournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Anaesthesia and Analgesia"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1111\/vaa.12271","type":"journal-article","created":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T10:43:54Z","timestamp":1430822634000},"page":"35-43","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of acepromazine or dexmedetomidine on fentanyl disposition in dogs during recovery from isoflurane anesthesia"],"prefix":"10.1016","volume":"43","author":[{"given":"Stephanie","family":"Keating","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn","family":"Kerr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne","family":"McDonell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Valverde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Knych","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Edginton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1111\/vaa.12271_bib1","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1467-2995.2008.00413.x","article-title":"Effects of morphine and fentanyl constant rate infusion on urine output in healthy and traumatized dogs","volume":"35","author":"Anderson","year":"2008","journal-title":"Vet Anaesth Analg"},{"key":"10.1111\/vaa.12271_bib2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/00000542-198410000-00001","article-title":"Fentanyl\u2019s analgesic, respiratory, and cardiovascular actions in relation to dose and plasma concentration in unanesthetized dogs","volume":"61","author":"Arndt","year":"1984","journal-title":"Anesthesiology"},{"key":"10.1111\/vaa.12271_bib3","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1211\/0022357001774985","article-title":"Clearance of fentanyl, alfentanil, methohexitone, thiopentone and ketamine in relation to estimated hepatic blood flow in several animal species: application to prediction of clearance in man","volume":"52","author":"Bj\u00f6rkman","year":"2000","journal-title":"J Pharm Pharmacol"},{"key":"10.1111\/vaa.12271_bib4","doi-asserted-by":"crossref","first-page":"325","DOI":"10.5326\/15473317-34-4-325","article-title":"Morbidity and mortality associated with anesthetic management in small animal veterinary practice in Ontario","volume":"34","author":"Dyson","year":"1998","journal-title":"J Am Anim Hosp Assoc"},{"key":"10.1111\/vaa.12271_bib5","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1467-2995.2006.00310.x","article-title":"Efficacy and cost-effectiveness of transdermal fentanyl patches for the relief of post-operative pain in dogs after anterior cruciate ligament and pelvic limb repair","volume":"34","author":"Egger","year":"2007","journal-title":"Vet Anaesth Analg"},{"key":"10.1111\/vaa.12271_bib6","doi-asserted-by":"crossref","first-page":"574","DOI":"10.2460\/ajvr.2005.66.574","article-title":"Influence of general anesthesia on pharmacokinetics of intravenous lidocaine infusion in horses","volume":"66","author":"Feary","year":"2005","journal-title":"Am J Vet Res"},{"key":"10.1111\/vaa.12271_bib7","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.2460\/ajvr.2005.66.1222","article-title":"Cardiopulmonary effects of fentanyl in conscious dogs and dogs sedated with a continuous rate infusion of medetomidine","volume":"66","author":"Grimm","year":"2005","journal-title":"Am J Vet Res"},{"key":"10.1111\/vaa.12271_bib8","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/BF03008300","article-title":"Influence of desflurane, isoflurane and halothane on regional tissue perfusion in dogs","volume":"39","author":"Hartman","year":"1992","journal-title":"Can J Anaesth"},{"key":"10.1111\/vaa.12271_bib9","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2460\/ajvr.2001.62.555","article-title":"Effects of diazepam and flumazenil on minimum alveolar concentrations for dogs anesthetized with isoflurane or a combination of isoflurane and fentanyl","volume":"62","author":"Hellyer","year":"2001","journal-title":"Am J Vet Res"},{"key":"10.1111\/vaa.12271_bib10","first-page":"248","article-title":"The cardiovascular sparing effect of fentanyl and atropine, administered to enflurane anesthetized dogs","volume":"58","author":"Ilkiw","year":"1994","journal-title":"Can J Vet Res"},{"key":"10.1111\/vaa.12271_bib11","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1532-950X.1994.tb00488.x","article-title":"Cardiorespiratory effects of four opioid\u2013tranquilizer combinations in dogs","volume":"23","author":"Jacobson","year":"1994","journal-title":"Vet Surg"},{"key":"10.1111\/vaa.12271_bib12","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1053\/bean.2000.0081","article-title":"Pharmacokinetics and interaction pharmacodynamics of dexmedetomidine in humans","volume":"14","author":"Karol","year":"2000","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"10.1111\/vaa.12271_bib13","series-title":"The cardiopulmonary effects and pharmacokinetics of fentanyl in the dog: the influence of isoflurane anesthesia and sedative administration during anesthetic recovery. DVSc thesis","first-page":"114","author":"Keating","year":"2013"},{"key":"10.1111\/vaa.12271_bib14","doi-asserted-by":"crossref","first-page":"672","DOI":"10.2460\/ajvr.74.5.672","article-title":"Cardiopulmonary effects of intravenous fentanyl infusion in dogs during isoflurane anesthesia and with concurrent acepromazine or dexmedetomidine administration during anesthetic recovery","volume":"74","author":"Keating","year":"2013","journal-title":"Am J Vet Res"},{"key":"10.1111\/vaa.12271_bib15","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1097\/00000542-199109000-00020","article-title":"Influence of dexmedetomidine and clonidine on human liver microsomal alfentanil metabolism","volume":"75","author":"Kharasch","year":"1991","journal-title":"Anesthesiology"},{"key":"10.1111\/vaa.12271_bib16","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1097\/00000542-199212000-00023","article-title":"Ketamine as a probe for medetomidine stereoisomer inhibition of human liver microsomal drug metabolism","volume":"77","author":"Kharasch","year":"1992","journal-title":"Anesthesiology"},{"key":"10.1111\/vaa.12271_bib17","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1213\/00000539-199612000-00005","article-title":"The effect of dexmedetomidine on nutrient organ blood flow","volume":"83","author":"Lawrence","year":"1996","journal-title":"Anesth Analg"},{"key":"10.1111\/vaa.12271_bib18","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1467-2995.2008.00412.x","article-title":"Effects of methadone, alone or in combination with acepromazine or xylazine, on sedation and physiologic values in dogs","volume":"35","author":"Monteiro","year":"2008","journal-title":"Vet Anaesth Analg"},{"key":"10.1111\/vaa.12271_bib19","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1097\/00000542-198212000-00009","article-title":"The anesthetic potency of fentanyl in terms of its reduction of enflurane MAC","volume":"57","author":"Murphy","year":"1982","journal-title":"Anesthesiology"},{"key":"10.1111\/vaa.12271_bib20","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0195-5616(08)70015-9","article-title":"Perioperative pain management","volume":"30","author":"Pascoe","year":"2000","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"10.1111\/vaa.12271_bib21","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2460\/ajvr.69.4.531","article-title":"Pharmacokinetics of remifentanil in conscious cats and cats anesthetized with isoflurane","volume":"69","author":"Pypendop","year":"2008","journal-title":"Am J Vet Res"},{"key":"10.1111\/vaa.12271_bib22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.5326\/15473317-35-2-95","article-title":"A comparison of transdermal fentanyl versus epidural morphine for analgesia in dogs undergoing major orthopedic surgery","volume":"35","author":"Robinson","year":"1999","journal-title":"J Am Anim Hosp Assoc"},{"key":"10.1111\/vaa.12271_bib23","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1097\/00000542-199404000-00017","article-title":"Anesthetic and hemodynamic interactions of dexmedetomidine and fentanyl in dogs","volume":"80","author":"Salmenper\u00e5","year":"1994","journal-title":"Anesthesiology"},{"key":"10.1111\/vaa.12271_bib24","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1467-2995.2005.00266.x","article-title":"Pharmacokinetics of fentanyl after single intravenous injection and constant rate infusion in dogs","volume":"33","author":"Sano","year":"2006","journal-title":"Vet Anaesth Analg"},{"key":"10.1111\/vaa.12271_bib25","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/bja\/81.1.38","article-title":"Recent advances and developments in the clinical use of i.v. opioids during the peroperative period","volume":"81","author":"Sear","year":"1998","journal-title":"Br J Anaesth"},{"key":"10.1111\/vaa.12271_bib26","doi-asserted-by":"crossref","first-page":"522","DOI":"10.2460\/javma.229.4.522","article-title":"Evaluation of the isoflurane-sparing effects of lidocaine and fentanyl during surgery in dogs","volume":"229","author":"Steagall","year":"2006","journal-title":"J Am Vet Med Assoc"},{"key":"10.1111\/vaa.12271_bib27","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1097\/00000539-200005000-00011","article-title":"The effect of \u03b12 agonist-induced sedation and its reversal with an \u03b12 antagonist on organ blood flow in sheep","volume":"90","author":"Talke","year":"2000","journal-title":"Anesth Analg"},{"key":"10.1111\/vaa.12271_bib28","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.2460\/ajvr.2005.66.1162","article-title":"Pharmacokinetics of lidocaine and its active metabolite, monoethylglycinexylidide, after intravenous administration of lidocaine to awake and isoflurane-anesthetized cats","volume":"66","author":"Thomasy","year":"2005","journal-title":"Am J Vet Res"},{"key":"10.1111\/vaa.12271_bib29","doi-asserted-by":"crossref","first-page":"54","DOI":"10.2746\/042516407X153011","article-title":"Influence of general anaesthesia on the pharmacokinetics of intravenous fentanyl and its primary metabolite in horses","volume":"39","author":"Thomasy","year":"2007","journal-title":"Equine Vet J"},{"key":"10.1111\/vaa.12271_bib30","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.2460\/ajvr.70.12.1459","article-title":"Effects of intravenous administration of perzinfotel, fentanyl, and a combination of both drugs on the minimum alveolar concentration of isoflurane in dogs","volume":"70","author":"Ueyama","year":"2009","journal-title":"Am J Vet Res"}],"container-title":["Veterinary Anaesthesia and Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298716300356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298716300356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T02:49:35Z","timestamp":1761446975000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1467298716300356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S1467298716300356"],"URL":"https:\/\/doi.org\/10.1111\/vaa.12271","relation":{},"ISSN":["1467-2987"],"issn-type":[{"type":"print","value":"1467-2987"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of acepromazine or dexmedetomidine on fentanyl disposition in dogs during recovery from isoflurane anesthesia","name":"articletitle","label":"Article Title"},{"value":"Veterinary Anaesthesia and Analgesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/vaa.12271","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}