{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:24:15Z","timestamp":1787016255332,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,9,20]],"date-time":"2012-09-20T00:00:00Z","timestamp":1348099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study reports the main clinicopathological features of primary lung cancer (\n                    <jats:styled-content style=\"fixed-case\">PLC<\/jats:styled-content>\n                    ) in 37 dogs, with special regard to the pathogenetic and prognostic role of epidermal growth factor receptor (\n                    <jats:styled-content style=\"fixed-case\">EGFR<\/jats:styled-content>\n                    ) overexpression. For each case the following characteristics were evaluated:\n                    <jats:styled-content style=\"fixed-case\">tumour\u2010node\u2010metastasis (TNM)<\/jats:styled-content>\n                    stage, tumour histotype, histological grade, mitotic activity and immunohistochemical expression of\n                    <jats:styled-content style=\"fixed-case\">EGFR<\/jats:styled-content>\n                    . In samples with available normal lung tissue, the amount of background anthracosis was also measured by image analysis. In 27 tumours (73%) a variable number of cells (20\u2013100%) stained positively for\n                    <jats:styled-content style=\"fixed-case\">EGFR<\/jats:styled-content>\n                    . The proportion of\n                    <jats:styled-content style=\"fixed-case\">EGFR<\/jats:styled-content>\n                    \u2010positive tumours was significantly higher in cases with background anthracosis, and the amount of anthracosis was correlated with the percentage of positive tumour cells. Additionally, a trend towards shortened survival for the high\n                    <jats:styled-content style=\"fixed-case\">EGFR<\/jats:styled-content>\n                    group was observed. These findings suggest an involvement of\n                    <jats:styled-content style=\"fixed-case\">EGFR<\/jats:styled-content>\n                    signalling pathway in canine\n                    <jats:styled-content style=\"fixed-case\">PLC<\/jats:styled-content>\n                    , a negative prognostic significance of protein overexpression and its potential implication in air pollution carcinogenesis.\n                  <\/jats:p>","DOI":"10.1111\/vco.12002","type":"journal-article","created":{"date-parts":[[2012,9,20]],"date-time":"2012-09-20T06:37:13Z","timestamp":1348123033000},"page":"237-248","source":"Crossref","is-referenced-by-count":35,"title":["<scp>EGFR<\/scp>\n                    overexpression in canine primary lung cancer: pathogenetic implications and impact on survival"],"prefix":"10.1111","volume":"12","author":[{"given":"S.","family":"Sabattini","sequence":"first","affiliation":[{"name":"Department of Veterinary Medical Sciences Alma Mater Studiorum \u2010 University of Bologna Ozzano Dell'Emilia Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. R.","family":"Mancini","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences Alma Mater Studiorum \u2010 University of Bologna Ozzano Dell'Emilia Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Marconato","sequence":"additional","affiliation":[{"name":"Veterinary Clinic dell'Orologio\/Veterinary Oncologic Center Sasso Marconi Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Bacci","sequence":"additional","affiliation":[{"name":"Veterinary Clinic dell'Orologio\/Veterinary Oncologic Center Sasso Marconi Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Rossi","sequence":"additional","affiliation":[{"name":"Veterinary Clinic dell'Orologio\/Veterinary Oncologic Center Sasso Marconi Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Vignoli","sequence":"additional","affiliation":[{"name":"Veterinary Clinic dell'Orologio\/Veterinary Oncologic Center Sasso Marconi Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Bettini","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences Alma Mater Studiorum \u2010 University of Bologna Ozzano Dell'Emilia Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,20]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"734","article-title":"Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung","volume":"8","author":"Piyathilake CJ","year":"2002","journal-title":"Clinical Cancer Research"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2004.01.002"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-2291"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.199"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405220101"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1981"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPO66OIRULFNLZ"},{"key":"e_1_2_5_9_1","first-page":"517","volume-title":"Withrow and MacEwen's Small Animal Clinical Oncology","author":"Withrow SJ","year":"2007"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1970.10667329"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1971.10665823"},{"key":"e_1_2_5_12_1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2460\/javma.1989.195.01.106","article-title":"Classification of primary lung tumors in dogs: 210 cases (1975\u20131985)","volume":"195","author":"Ogilvie GK","year":"1989","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116276"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/14622200701648391"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2009.09.004"},{"key":"e_1_2_5_16_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2460\/javma.1989.195.01.109","article-title":"Prognostic factors for tumor remission and survival in dogs after surgery for primary lung tumor: 76 cases (1975\u20131985)","volume":"195","author":"Ogilvie GK","year":"1989","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_17_1","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.2460\/javma.1997.211.11.1422","article-title":"Evaluation of prognostic factors for dogs with primary lung tumors: 67 cases (1985 \u2013 1992)","volume":"211","author":"McNiel EA","year":"1997","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.42-3-315"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2008.00166.x"},{"key":"e_1_2_5_20_1","volume-title":"TNM Classification of Tumors in Domestic Animals","author":"Owen LN","year":"1980"},{"key":"e_1_2_5_21_1","volume-title":"World Health Organization International Histological Classification of Tumors of Domestic Animals \u2010 Histological Classification of Tumors of the Respiratory System of Domestic Animals, 2nd Series","author":"Dungworth DL","year":"1999"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2008.00178.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms1939.47.811"},{"key":"e_1_2_5_24_1","first-page":"1628","article-title":"Primary pulmonary neoplasms in the dog: a review of 29 cases","volume":"147","author":"Brodey RS","year":"1965","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470376928.ch7"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2007.00403.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.2983"},{"key":"e_1_2_5_28_1","first-page":"359","volume-title":"Canine Anatomy","author":"Smith BJ","year":"1999"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2008.08.015"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.05.011"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.11.069"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-376"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5810.2006.00091.x"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2006.00101.x"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2009.04.016"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2010.04.010"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098589202900106"},{"key":"e_1_2_5_38_1","first-page":"403","article-title":"Epidermal growth factor receptor expression in human lung carcinomas defined by a monoclonal antibody","volume":"79","author":"Sobol RE","year":"1987","journal-title":"Journal of National Cancer Institute"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.525"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)67604-3"},{"key":"e_1_2_5_41_1","first-page":"613","article-title":"EGFR and steroid receptors in ovarian carcinoma: comparison with prognostic parameters and outcome of patients","volume":"17","author":"Fischer\u2010Colbrie J","year":"1997","journal-title":"Anticancer Research"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02482343"},{"key":"e_1_2_5_43_1","first-page":"7077","article-title":"Immunohistochemical evidence of autocrine growth factors in adenocarcinoma of the human lung","volume":"50","author":"Tateishi M","year":"1990","journal-title":"Cancer Research"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(01)00231-3"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh011"},{"key":"e_1_2_5_46_1","first-page":"515","article-title":"Overexpression of the epidermal growth factor receptor and its ligand transforming growth factor is frequent in resectable non\u2010small cell lung cancer but does not predict tumor progression","volume":"3","author":"Rusch V","year":"1997","journal-title":"Clinical Cancer Research"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(93)00421-M"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.320"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2010.00239.x"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23282"},{"key":"e_1_2_5_51_1","first-page":"4724","article-title":"K\u2010ras activation in non\u2010small cell lung cancer in the dog","volume":"52","author":"Kraegel SA","year":"1992","journal-title":"Cancer Research"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/19.6.959"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4229"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvco.12002","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T22:34:06Z","timestamp":1744151646000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.12002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,20]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1111\/vco.12002"],"URL":"https:\/\/doi.org\/10.1111\/vco.12002","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,20]]}}}