{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T19:34:43Z","timestamp":1769456083449,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,10,19]],"date-time":"2012-10-19T00:00:00Z","timestamp":1350604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sterile haemorrhagic cystitis (<jats:styled-content style=\"fixed-case\">SHC<\/jats:styled-content>) is a known risk of cyclophosphamide treatment; however, most canine reports are case series. This case\u2013control study examined risk factors for<jats:styled-content style=\"fixed-case\">SHC<\/jats:styled-content>in dogs with lymphoma receiving oral cyclophosphamide. Twenty\u2010two dogs with<jats:styled-content style=\"fixed-case\">SHC<\/jats:styled-content>and 66 control dogs were identified. On univariate analysis,<jats:styled-content style=\"fixed-case\">SHC<\/jats:styled-content>risk factors included age (<jats:italic>P<\/jats:italic>\u2009=\u20090.041), induction protocol (<jats:italic>P<\/jats:italic>\u2009=\u20090.021) and cumulative cyclophosphamide dose (<jats:italic>P<\/jats:italic>\u2009=\u20090.002). On multivariate analysis, increasing cumulative cyclophosphamide dose was associated with increased risk of<jats:styled-content style=\"fixed-case\">SHC<\/jats:styled-content>and the \u2018short\u2019 induction protocol (protocol 1) was associated with decreased risk. Controlling for age and induction protocol, odds of<jats:styled-content style=\"fixed-case\">SHC<\/jats:styled-content>increased by 2.21 per 750\u2009mg\u2009m<jats:sup>\u22122<\/jats:sup>increase in cyclophosphamide dose (<jats:italic>P<\/jats:italic>\u2009=\u20090.001).<jats:styled-content style=\"fixed-case\">SHC<\/jats:styled-content>from oral cyclophosphamide is a predominately delayed toxicity resulting from high cumulative doses.<\/jats:p>","DOI":"10.1111\/vco.12009","type":"journal-article","created":{"date-parts":[[2012,10,19]],"date-time":"2012-10-19T08:07:37Z","timestamp":1350634057000},"page":"277-286","source":"Crossref","is-referenced-by-count":18,"title":["Risk factors for development of sterile haemorrhagic cystitis in canine lymphoma patients receiving oral cyclophosphamide: a case\u2013control study"],"prefix":"10.1111","volume":"12","author":[{"given":"R.","family":"Gaeta","sequence":"first","affiliation":[{"name":"Department of Clinical Studies Matthew J. Ryan Veterinary Hospital University of Pennsylvania School of Veterinary Medicine Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies Matthew J. Ryan Veterinary Hospital University of Pennsylvania School of Veterinary Medicine Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies Matthew J. Ryan Veterinary Hospital University of Pennsylvania School of Veterinary Medicine Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Sorenmo","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies Matthew J. 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