{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:30:34Z","timestamp":1788849034034,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T00:00:00Z","timestamp":1357516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The aim of this retrospective study was to describe clinical features, treatment and outcome of 21 dogs with metastatic cancer of unknown primary (\n                    <jats:styled-content style=\"fixed-case\">MCUP<\/jats:styled-content>\n                    ), a biopsy\u2010proven malignancy being diagnosed at a metastatic stage, in which the anatomical origin of the primary tumour cannot be detected. All dogs underwent total\u2010body computed tomography. Signalment, type and duration of clinical signs, metastasis site, pathology results, treatment and outcome were recorded. Carcinoma was the most common diagnosis (57.1%), followed by sarcoma, melanoma and mast cell tumour. The median number of disease sites per dog was 2, with bones, lymph nodes, lungs and spleen being the most frequent metastatic locations. The median survival for all dogs was 30\u2009days. Overall, a primary site was not identified in 20 (95.2%) dogs.\n                    <jats:styled-content style=\"fixed-case\">MCUP<\/jats:styled-content>\n                    encompasses a variety of different pathologic entities and harbours a poor prognosis.\n                  <\/jats:p>","DOI":"10.1111\/vco.12011","type":"journal-article","created":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T13:23:32Z","timestamp":1357565012000},"page":"11-19","source":"Crossref","is-referenced-by-count":25,"title":["Metastatic cancer of unknown primary in\u00a021 dogs"],"prefix":"10.1111","volume":"13","author":[{"given":"F.","family":"Rossi","sequence":"first","affiliation":[{"name":"Centro Oncologico Veterinario  Sasso Marconi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Aresu","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedicine and Nutrition University of Padova  Legnaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Vignoli","sequence":"additional","affiliation":[{"name":"Centro Oncologico Veterinario  Sasso Marconi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Buracco","sequence":"additional","affiliation":[{"name":"Department of Animal Pathology Veterinary School  Grugliasco Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Bettini","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ferro","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedicine and Nutrition University of Padova  Legnaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Gattino","sequence":"additional","affiliation":[{"name":"Department of Animal Pathology Veterinary School  Grugliasco Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Ghiani","sequence":"additional","affiliation":[{"name":"Studio Veterinario Associato Costa\u2010Ghiani\u2010Spallarossa  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Costantino","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Orobica  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Ressel","sequence":"additional","affiliation":[{"name":"Diagnostica Veterinaria di Laboratorio  Sasso Marconi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Bellei","sequence":"additional","affiliation":[{"name":"Centro Medico Veterinario  Finale Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Marconato","sequence":"additional","affiliation":[{"name":"Centro Oncologico Veterinario  Sasso Marconi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2008.09.005"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950101)75:1 <353::AID-CNCR2820751317>3.0.CO;2-P"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(03)00547-1"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg742"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1001\/archinte.1988.00380090101024","article-title":"Early metastatic cancer of unknown primary origin at presentation. 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