{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:19:04Z","timestamp":1759940344695},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T00:00:00Z","timestamp":1366848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq, Bras\u00edlia, Brazil)"},{"name":"The Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo (FAPESP, S\u00e3o Paulo, Brazil)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A lipid nanoemulsion (<jats:styled-content style=\"fixed-case\">LDE<\/jats:styled-content>) resembling low\u2010density lipoprotein can target malignant tumours. In<jats:italic>in vivo<\/jats:italic>and clinical studies, association of chemotherapeutic agents to<jats:styled-content style=\"fixed-case\">LDE<\/jats:styled-content>decreased their toxicity and increased pharmacological action. Here, safety of<jats:styled-content style=\"fixed-case\">LDE<\/jats:styled-content>as carmustine carrier (50 mg m<jats:sup>\u22122<\/jats:sup>, intravenous) combined with vincristine and prednisone for the treatment of dogs with lymphoma was tested and compared with commercial carmustine with vincristine and prednisone. In five dogs from<jats:styled-content style=\"fixed-case\">LDE<\/jats:styled-content>\u2010carmustine and six from commercial carmustine, complete remission was achieved (<jats:italic>P<\/jats:italic>&gt; 0.05). Partial remission occurred in two dogs from each group. In both groups, the median progression\u2010free intervals (119 and 199 days) and overall survival times (207 and 247 days) were equal. Neutropenia was observed in both groups, but no other major toxicities occurred. Therefore, no difference was observed between the treatments.<jats:styled-content style=\"fixed-case\">LDE<\/jats:styled-content>\u2010carmustine was shown to be safe and effective in a drug combination protocol, which encourages larger studies to investigate the use of this novel formulation to treat canine lymphomas.<\/jats:p>","DOI":"10.1111\/vco.12033","type":"journal-article","created":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T07:14:43Z","timestamp":1366874083000},"page":"184-193","source":"Crossref","is-referenced-by-count":10,"title":["Pilot clinical study of carmustine associated with a lipid nanoemulsion in combination with vincristine and prednisone for the treatment of canine lymphoma"],"prefix":"10.1111","volume":"13","author":[{"given":"S. R. R.","family":"Lucas","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, School of Veterinary Medicine and Animal Science University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. C.","family":"Maranh\u00e3o","sequence":"additional","affiliation":[{"name":"Lipid Metabolism Laboratory, Heart Institute (InCor), Medical School Hospital University of S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Department of Clinical Biochemistry, Faculty of Pharmaceutical Sciences University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Guerra","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Veterinary Medicine and Animal Science University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. M. P.","family":"Coelho","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Medical School Hospital University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Barboza","sequence":"additional","affiliation":[{"name":"Lipid Metabolism Laboratory, Heart Institute (InCor), Medical School Hospital University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. H. B.","family":"Pozzi","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Medical School Hospital University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.2460\/javma.1994.205.12.1722","article-title":"Prognostic factors for treatment of malignant lymphoma in dogs","volume":"205","author":"Teske E","year":"1994","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_7_3_1","first-page":"159","article-title":"Treatment of lymphoma and leukemia with cyclophosphamide vincristine and prednisone. I. Treatment of dogs","volume":"19","author":"Cotter SM","year":"1983","journal-title":"Journal of the American Animal Hospital Association"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.2460\/javma.1991.198.010.1762","article-title":"Weekly administration of low\u2010dose doxorubicin for treatment of malignant lymphoma in dogs","volume":"198","author":"Ogilvie GK","year":"1991","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1999.tb01452.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2002.tb02411.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.5326\/0400292"},{"key":"e_1_2_7_8_1","first-page":"4734","article-title":"Liposomes as in vivo carriers of adriamycin: reduced cardiac uptake and preserved antitumoral activity in mice","volume":"42","author":"Gabizon A","year":"1982","journal-title":"Cancer Research"},{"key":"e_1_2_7_9_1","first-page":"5427","article-title":"Prevention of chronic doxorubicin cardiotoxicity in beagles by liposomal encapsulation","volume":"43","author":"Herman EH","year":"1983","journal-title":"Cancer Research"},{"key":"e_1_2_7_10_1","first-page":"43","article-title":"Monoclonal antibody therapy of cancer","volume":"26","author":"Weiner LM","year":"1999","journal-title":"Seminars in Oncology"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V52.6.1099.1099"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910280310"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.7.2598"},{"key":"e_1_2_7_14_1","first-page":"1003","article-title":"Increased plasma removal of microemulsions resembling the lipid phase of low\u2010density lipoproteins (LDL) in patients with acute myeloid leukemia: a possible new strategy for the treatment of the disease","volume":"25","author":"Maranh\u00e3o RC","year":"1992","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"e_1_2_7_15_1","first-page":"4660","article-title":"Plasma kinetics and biodistribution of a lipid emulsion resembling low\u2010density lipoprotein in patients with acute leukemia","volume":"54","author":"Maranh\u00e3o RC","year":"1994","journal-title":"Cancer Research"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-002-0437-3"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1211\/0022357022232"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1211\/0022357021779104"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2001001000004"},{"key":"e_1_2_7_20_1","first-page":"2285","article-title":"Novel formulation of a methotrexate derivative with a lipid nanoemulsion","volume":"6","author":"Moura JA","year":"2011","journal-title":"International Journal of Nanomedicine"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.60.10.0004"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e318241c385"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.58.6.0010"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1211\/0022357023826"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-004-0930-y"},{"key":"e_1_2_7_26_1","first-page":"179","article-title":"Carmustine\u2010induced partial remission of an astrocytoma in a dog","volume":"26","author":"Dimsky DS","year":"1990","journal-title":"Journal of the American Animal Hospital Association"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-7372(82)80043-1"},{"key":"e_1_2_7_28_1","first-page":"p3200","volume-title":"Cancer: Principles and Practice of Oncology","author":"De Vita VT","year":"2008"},{"key":"e_1_2_7_29_1","volume-title":"Bone Marrow Toxicity Induced by Carmustine (BCNU) in Dogs","author":"Miyashiro SI","year":"2001"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-003-0692-y"},{"key":"e_1_2_7_31_1","doi-asserted-by":"crossref","first-page":"8216","DOI":"10.1016\/S0021-9258(18)34320-5","article-title":"Microemulsions of phospholipids and cholesterol esters","volume":"257","author":"Ginsburg GS","year":"1982","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02535988"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2009.00200.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2011.00283.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.1996.tb00968.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-005-0090-8"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2002.6654"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.10.018"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-008-0738-2"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2001.6203"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.12.015"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-006-0252-3"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvco.12033","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T13:37:06Z","timestamp":1715261826000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.12033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,25]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/vco.12033"],"URL":"https:\/\/doi.org\/10.1111\/vco.12033","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,25]]}}}