{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T21:51:19Z","timestamp":1767649879465,"version":"3.37.3"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T00:00:00Z","timestamp":1367971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"crossref","award":["D08FE-023, D09FE-404"],"award-info":[{"award-number":["D08FE-023, D09FE-404"]}],"id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institutes of Health, National Cancer Center","award":["F32 CA130458"],"award-info":[{"award-number":["F32 CA130458"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oral squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>) is common in cats and humans and invades oral bone. We hypothesized that the cyclooxygenase (<jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>)\u20102 inhibitor, meloxicam, with the bisphosphonate, zoledronic acid (<jats:styled-content style=\"fixed-case\">ZOL<\/jats:styled-content>), would inhibit tumour growth, osteolysis and invasion in feline <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content> xenografts in mice. Human and feline <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content> cell lines expressed <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20101 and COX\u20102 and the <jats:styled-content style=\"fixed-case\">SCCF2<\/jats:styled-content> cells had increased <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression with bone conditioned medium. Luciferase\u2010expressing feline <jats:styled-content style=\"fixed-case\">SCCF2Luc<\/jats:styled-content> cells were injected beneath the perimaxillary gingiva and mice were treated with 0.1 mg kg<jats:sup>\u22121<\/jats:sup> <jats:styled-content style=\"fixed-case\">ZOL<\/jats:styled-content> twice weekly, 0.3 mg kg<jats:sup>\u22121<\/jats:sup> meloxicam daily, combined <jats:styled-content style=\"fixed-case\">ZOL<\/jats:styled-content> and meloxicam, or vehicle. <jats:styled-content style=\"fixed-case\">ZOL<\/jats:styled-content> inhibited osteoclastic bone resorption at the tumour\u2013bone interface. Meloxicam was more effective than <jats:styled-content style=\"fixed-case\">ZOL<\/jats:styled-content> at reducing xenograft growth but did not affect osteoclastic bone resorption. Although a synergistic effect of combined <jats:styled-content style=\"fixed-case\">ZOL<\/jats:styled-content> and meloxicam was not observed, combination therapy was well\u2010tolerated and may be useful in the clinical management of bone\u2010invasive feline <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/vco.12037","type":"journal-article","created":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T07:36:29Z","timestamp":1367998589000},"page":"203-217","source":"Crossref","is-referenced-by-count":17,"title":["Combined zoledronic acid and meloxicam reduced bone loss and tumour growth in an orthotopic mouse model of bone\u2010invasive oral squamous cell carcinoma"],"prefix":"10.1111","volume":"13","author":[{"given":"C. K.","family":"Martin","sequence":"first","affiliation":[{"name":"Department of Veterinary Biosciences College of Veterinary Medicine  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. P.","family":"Dirksen","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences College of Veterinary Medicine  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M.","family":"Carlton","sequence":"additional","affiliation":[{"name":"Small Animal Imaging Center Shared Resource Comprehensive Cancer Center, The Ohio State University  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. G.","family":"Lanigan","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences College of Veterinary Medicine  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. P.","family":"Pillai","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences College of Veterinary Medicine  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Werbeck","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences College of Veterinary Medicine  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. K.","family":"Simmons","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences College of Veterinary Medicine  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"B. E.","family":"Hildreth","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences College of Veterinary Medicine  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. A.","family":"London","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences College of Veterinary Medicine  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. E.","family":"Toribio","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences College of Veterinary Medicine  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. J.","family":"Rosol","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences College of Veterinary Medicine  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,8]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1202","article-title":"Epidemiologic analysis of oral and pharyngeal cancer in dogs, cats, horses, and cattle","volume":"169","author":"Dorn CR","year":"1976","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470690406.ch7"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810384414"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(84)90171-X"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198503000-00014"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1290\/1071-2690(2001)037<0676:FHANSC>2.0.CO;2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-127-1-305"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2005.03.008"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001101)89:9<1966::AID-CNCR13>3.0.CO;2-R"},{"key":"e_1_2_6_11_1","first-page":"991","article-title":"Cyclooxygenase\u20102 expression is up\u2010regulated in squamous cell carcinoma of the head and neck","volume":"59","author":"Chan G","year":"1999","journal-title":"Cancer Research"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukarGeneExpr.v10.i2.50"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:8:3:291"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.5.844"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2012"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(94)90250-X"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.12.012"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2006.06.001"},{"key":"e_1_2_6_19_1","first-page":"362","article-title":"Modulation of apoptosis and Bcl\u20102 expression by prostaglandin E2 in human colon cancer cells","volume":"58","author":"Sheng H","year":"1998","journal-title":"Cancer Research"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81433-6"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.7.3336"},{"key":"e_1_2_6_22_1","first-page":"1208","article-title":"Non\u2010small cell lung cancer cyclooxygenase\u20102\u2010dependent regulation of cytokine balance in lymphocytes and macrophages: up\u2010regulation of interleukin 10 and down\u2010regulation of interleukin 12 production","volume":"58","author":"Huang M","year":"1998","journal-title":"Cancer Research"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650040106"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/10507250152039073"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650051004"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601643103"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-006-9008-z"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20776"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-011-9377-9"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-0850"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-1767"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20167"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200205000-00012"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-1684"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2004.12.048"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.02.024"},{"issue":"6","key":"e_1_2_6_37_1","first-page":"4245","article-title":"COX\u20102 inhibitor celecoxib suppresses tumor growth and lung metastasis of a murine mammary cancer","volume":"26","author":"Yoshinaka R","year":"2006","journal-title":"Anticancer Research"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(89)90115-8"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428191003646697"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5810.2006.00096.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2010.03.015"},{"key":"e_1_2_6_42_1","first-page":"425","article-title":"Differential effects of selective cyclooxygenase\u20102 inhibitors in inhibiting proliferation and induction of apoptosis in oral squamous cell carcinoma","volume":"19","author":"Ko SH","year":"2008","journal-title":"Oncology Reports"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23288"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi240"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2009.01306.x"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02940318"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2006.02.009"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09947.x"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5810.2006.00091.x"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2010.00239.x"},{"key":"e_1_2_6_51_1","first-page":"235","article-title":"Structure\u2010activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen\u2010containing bisphosphonates","volume":"296","author":"Dunford JE","year":"2001","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-200212001-00002"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.4.581"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5350.509"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090592"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802633"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70305-X"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1532-3382(12)70046-5"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvco.12037","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T15:30:49Z","timestamp":1696174249000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.12037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,8]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/vco.12037"],"URL":"https:\/\/doi.org\/10.1111\/vco.12037","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"type":"print","value":"1476-5810"},{"type":"electronic","value":"1476-5829"}],"subject":[],"published":{"date-parts":[[2013,5,8]]}}}