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This study evaluated the use of masitinib as a frontline and rescue agent for metastatic and non\u2010metastatic canine <jats:styled-content style=\"fixed-case\">MCT<\/jats:styled-content>s. Identification of toxicities and prognostic factors in these dogs was of secondary interest. Twenty\u2010six dogs were included in this study. The overall response rate to masitinib was 50%. The median survival time for dogs that responded to masitinib was 630 days versus 137 days for dogs that did not respond (<jats:italic>P<\/jats:italic> = 0.0033). Toxicity was recorded in 61.5% of treated dogs, but the majority of adverse events were mild and self\u2010limiting. Response to masitinib, not tumour grade, stage or location, was the most significant prognostic factor for survival in dogs with <jats:styled-content style=\"fixed-case\">MCT<\/jats:styled-content>s.<\/jats:p>","DOI":"10.1111\/vco.12053","type":"journal-article","created":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T06:32:12Z","timestamp":1373610732000},"page":"314-321","source":"Crossref","is-referenced-by-count":27,"title":["Masitinib mesylate for metastatic and non\u2010resectable canine cutaneous mast cell tumours"],"prefix":"10.1111","volume":"13","author":[{"given":"O. 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