{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T16:23:20Z","timestamp":1793809400170,"version":"4.6.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,7]],"date-time":"2013-11-07T00:00:00Z","timestamp":1383782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Thymic epithelial tumour (\n                    <jats:styled-content style=\"fixed-case\">TET<\/jats:styled-content>\n                    ) histologic subclassification has not been well described in the veterinary literature as it has in humans. The objective of this study was to identify and describe\n                    <jats:styled-content style=\"fixed-case\">TET<\/jats:styled-content>\n                    subtypes in dogs and to determine the utility of immunohistochemistry (\n                    <jats:styled-content style=\"fixed-case\">IHC<\/jats:styled-content>\n                    ) in differentiating these subtypes. Samples were reviewed and classified according to a modified World Health Organization (\n                    <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content>\n                    ) criteria for human tumours of thymic origin. Signallment, presenting signs, treatment and survival data was collected from medical records. Histologic review confirmed the same subtypes as described in humans. Presence of high stage disease, pleomorphism, mitotic figures and capsular invasion was more common in atypical thymomas and thymic carcinomas than in thymomas.\n                    <jats:styled-content style=\"fixed-case\">IHC<\/jats:styled-content>\n                    was performed for\n                    <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>\n                    \u20101,\n                    <jats:styled-content style=\"fixed-case\">CD5<\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">CD117<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">CK8<\/jats:styled-content>\n                    \/18; however, this was not useful in classifying the tumours.\n                  <\/jats:p>","DOI":"10.1111\/vco.12072","type":"journal-article","created":{"date-parts":[[2013,11,7]],"date-time":"2013-11-07T07:52:40Z","timestamp":1383810760000},"page":"113-121","source":"Crossref","is-referenced-by-count":22,"title":["Histologic and immunohistochemical characterization of thymic epithelial tumours in the dog"],"prefix":"10.1111","volume":"14","author":[{"given":"K. E.","family":"Burgess","sequence":"first","affiliation":[{"name":"Harrington Oncology Program, Department of Clinical Sciences Cummings School of Veterinary Medicine at Tufts University North Grafton MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. J.","family":"DeRegis","sequence":"additional","affiliation":[{"name":"Harrington Oncology Program, Department of Clinical Sciences Cummings School of Veterinary Medicine at Tufts University North Grafton MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. S.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Pathology Cummings School of Veterinary Medicine at Tufts University North Grafton MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. H.","family":"Keating","sequence":"additional","affiliation":[{"name":"Department of Pathology Cummings School of Veterinary Medicine at Tufts University North Grafton MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470376928.ch3"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11099"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2009.05.038"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.11.067"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19811201)48:11<2485::AID-CNCR2820481123>3.0.CO;2-R"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10226"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181a4b8e0"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-60157-6_3"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-009-0084-6"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10255"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.105"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098587601300505"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-37-5-489"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.232.8.1186"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1997.tb03492.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.2460\/javma.1984.184.11.1355","article-title":"Clinical and pathologic features of thymoma in 15 dogs","volume":"184","author":"Aronsohn MG","year":"1984","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_18_1","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.2460\/javma.1994.205.07.1007","article-title":"Thymoma in dogs: 23 cases (1980\u20131991)","volume":"205","author":"Atwater SW","year":"1994","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.12.095"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540405200515"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2005.10.001"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.36-3-179"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/jcpa.1999.0372"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.69.233"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.134.6.141"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2003.tb12883.x"},{"key":"e_1_2_5_27_1","first-page":"268","article-title":"CD5 expression in thymic carcinoma","volume":"145","author":"Hishima T","year":"1994","journal-title":"American Journal of Pathology"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2007.00155.x"},{"key":"e_1_2_5_29_1","first-page":"360","article-title":"Immunohistochemical detection of intermediate filament proteins in formalin fixed normal and neoplastic canine tissues","volume":"54","author":"Desnoyers MM","year":"1990","journal-title":"Canadian Journal of Veterinary Research"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvco.12072","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T15:48:39Z","timestamp":1746028119000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.12072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,7]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/vco.12072"],"URL":"https:\/\/doi.org\/10.1111\/vco.12072","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,7]]}}}