{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T15:48:44Z","timestamp":1774972124507,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T00:00:00Z","timestamp":1398297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transitional cell carcinoma (<jats:styled-content style=\"fixed-case\">TCC<\/jats:styled-content>) is a urinary bladder tumour associated with high mortality in dogs. In this study, we investigated the feasibility of using p63, Ki67 or <jats:italic>\u03b2<\/jats:italic>\u2010catenin as a clinical marker for predicting biological behaviour and prognosis in canine <jats:styled-content style=\"fixed-case\">TCC<\/jats:styled-content>. Expression levels of these proteins in <jats:styled-content style=\"fixed-case\">TCC<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u2009=\u200925), polypoid cystitis (<jats:italic>n<\/jats:italic>\u2009=\u20095) and normal urinary bladder (<jats:italic>n<\/jats:italic>\u2009=\u20095) were scored after immunohistochemical staining. The staining scores for p63 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and <jats:italic>\u03b2<\/jats:italic>\u2010catenin (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) in <jats:styled-content style=\"fixed-case\">TCC<\/jats:styled-content> were significantly lower than those in normal urinary bladder and polypoid cystitis. In contrast, Ki67 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) staining scores in <jats:styled-content style=\"fixed-case\">TCC<\/jats:styled-content> were significantly higher than those in normal urinary bladder and polypoid cystitis. In <jats:styled-content style=\"fixed-case\">TCC<\/jats:styled-content>, low p63 expression was significantly related to the presence of vessel invasion (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and metastasis (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) as well as short survival time (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). These findings show that p63 could be a reliable marker for predicting prognosis in canine <jats:styled-content style=\"fixed-case\">TCC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/vco.12095","type":"journal-article","created":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T09:50:35Z","timestamp":1398333035000},"page":"263-269","source":"Crossref","is-referenced-by-count":14,"title":["Immunohistochemical expression of p63, Ki67 and <i>\u03b2<\/i>\u2010catenin in canine transitional cell carcinoma and polypoid cystitis of the urinary bladder"],"prefix":"10.1111","volume":"14","author":[{"given":"K.","family":"Hanazono","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences, School of Veterinary Medicine Rakuno Gakuen University  Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Nishimori","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, School of Veterinary Medicine Rakuno Gakuen University  Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, School of Veterinary Medicine Rakuno Gakuen University  Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, School of Veterinary Medicine Rakuno Gakuen University  Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, School of Veterinary Medicine Rakuno Gakuen University  Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kadosawa","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, School 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