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Some mesenchymal tumours (often resembling haemangiopericytomas) express molecules that normally regulate phosphorus metabolism; most frequently, fibroblast growth factor 23. Patients develop renal phosphate wasting and inappropriately low serum concentrations of 1, 25 (OH)<jats:sub>2<\/jats:sub> vitamin D<jats:sub>3<\/jats:sub>, leading to osteomalacia. Surgical removal of the tumour is curative. The authors examined expression of canine fibroblast growth factor 23 in 49 soft tissue sarcomas, and control tissues from normal adult dogs. RNA extracted from bone or formalin\u2010fixed, paraffin\u2010embedded tissues was analysed by end point and quantitative reverse transcriptase\u2010polymerase chain reaction. Fibroblast growth factor 23 expression was detected in bone, lung, kidney, lymph node and thymus. Fifteen of 49 sarcomas (31%) expressed fibroblast growth factor 23, three of these had high relative expression and some features resembling phosphatonin\u2010expressing mesenchymal tumours of humans. Further work is required to determine whether TIO may occur in dogs.<\/jats:p>","DOI":"10.1111\/vco.12105","type":"journal-article","created":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T07:34:20Z","timestamp":1402644860000},"page":"306-317","source":"Crossref","is-referenced-by-count":3,"title":["Expression of fibroblast growth factor 23 by canine soft tissue sarcomas"],"prefix":"10.1111","volume":"14","author":[{"given":"M. R.","family":"Hardcastle","sequence":"first","affiliation":[{"name":"Institute of Veterinary, Animal and Biomedical Sciences, College of Sciences Massey University  Palmerston North New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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