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The purpose of this study was to determine if extent of surgical excision affects recurrence rate in dogs with grade<jats:styled-content style=\"fixed-case\">II MCT<\/jats:styled-content>with low proliferation activity, determined by Ki67 and argyrophilic nucleolar organising regions (<jats:styled-content style=\"fixed-case\">AgNOR<\/jats:styled-content>). Eighty\u2010six dogs with cutaneous<jats:styled-content style=\"fixed-case\">MCT<\/jats:styled-content>were evaluated. All dogs had surgical excision of their<jats:styled-content style=\"fixed-case\">MCT<\/jats:styled-content>with a low Ki67 index and combined<jats:styled-content style=\"fixed-case\">AgNORxKi67<\/jats:styled-content>(Ag67) values. Twenty\u2010three (27%) dogs developed local or distant recurrence during the median follow\u2010up time. Of these dogs, six (7%) had local recurrence, one had complete and five had incomplete histologic margins. This difference in recurrence rates between dogs with complete and incomplete histologic margins was not significant. On the basis of this study, ancillary therapy may not be necessary for patients with incompletely excised grade<jats:styled-content style=\"fixed-case\">II MCT<\/jats:styled-content>with low proliferation activity.<\/jats:p>","DOI":"10.1111\/vco.12140","type":"journal-article","created":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T12:02:20Z","timestamp":1422964940000},"page":"36-45","source":"Crossref","is-referenced-by-count":31,"title":["Recurrence rates and clinical outcome for dogs with grade<scp>II<\/scp>mast cell tumours with a low<scp>AgNOR<\/scp>count and Ki67 index treated with surgery alone"],"prefix":"10.1111","volume":"15","author":[{"given":"J.","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Chicago Veterinary Cancer Center Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kiupel","sequence":"additional","affiliation":[{"name":"Diagnostic Center for Population and Animal Health 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Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Brocks","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences of Companion Animals, Utrecht University Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Post","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, The Veterinary Cancer Center Norwalk CT 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