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The utility of detection of antigen receptor gene rearrangement by polymerase chain reaction (<jats:styled-content style=\"fixed-case\">PARR<\/jats:styled-content>) in canine lymphoma has been well established, but its usefulness to distinguish enteritis and intestinal lymphoma remains unclear. In this retrospective study we assessed clonality of 29 primary canine intestinal lymphoma, 14 enteritis and 15 healthy control cases by <jats:styled-content style=\"fixed-case\">PARR<\/jats:styled-content> analysis, using formalin\u2010fixed, paraffin\u2010embedded full\u2010thickness tissue specimens. We could detect monoclonal rearrangements in 22 of 29 canine intestinal lymphomas [76%; 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 56\u201390%] and polyclonal rearrangements in all of the enteritis and healthy control cases (100%; <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 88\u2013100%). We revealed a predominance of T\u2010cell phenotype compared to B\u2010cell phenotype (85%; <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 65\u201396% and 15%; <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 4\u201335%, respectively). We showed that <jats:styled-content style=\"fixed-case\">PARR<\/jats:styled-content> analysis contributes to differentiation of canine intestinal lymphoma from enteritis and to phenotyping of lymphomas.<\/jats:p>","DOI":"10.1111\/vco.12151","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T05:23:50Z","timestamp":1432013030000},"page":"194-207","source":"Crossref","is-referenced-by-count":17,"title":["Detection of monoclonality in intestinal lymphoma with polymerase chain reaction for antigen receptor gene rearrangement analysis to differentiate from enteritis in dogs"],"prefix":"10.1111","volume":"15","author":[{"given":"S.","family":"Ohmura","sequence":"first","affiliation":[{"name":"Clinic of Small Animal Medicine, Center for Clinical Veterinary Medicine Ludwig Maximilian University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Leipig","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Pathology Ludwig Maximilian University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Sch\u00f6pper","sequence":"additional","affiliation":[{"name":"Clinic of Small Animal Medicine, Center for Clinical Veterinary Medicine Ludwig Maximilian University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Hergt","sequence":"additional","affiliation":[{"name":"Clinic of Small Animal Medicine, Center for Clinical Veterinary Medicine Ludwig Maximilian University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Weber","sequence":"additional","affiliation":[{"name":"Clinic of Small Animal Medicine, Center for Clinical Veterinary Medicine Ludwig Maximilian University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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