{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T10:43:47Z","timestamp":1769856227193,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The frequency of normoblastemia in dogs receiving chemotherapy is unknown. To provide this information, we calculated the percentage and number of nucleated erythrocytes (<jats:styled-content style=\"fixed-case\">nRBCs<\/jats:styled-content>) in blood of dogs treated for lymphoma (<jats:italic>n<\/jats:italic>\u2009=\u2009284), mast cell tumour (<jats:italic>n<\/jats:italic>\u2009=\u200940) or carcinoma (<jats:italic>n<\/jats:italic>\u2009=\u200946). Relative normoblastemia (&gt;1 or &gt;5%) and absolute normoblastemia (&gt;0.1 or &gt;0.4\u2009\u00d7\u200910<jats:sup>3<\/jats:sup>\u2009<jats:styled-content style=\"fixed-case\">\u00b5L<\/jats:styled-content><jats:sup>\u22121<\/jats:sup>) were found after administration of vincristine (49.3, 20.5, 42.5, 19.2%, respectively), carboplatin (37.0, 2.2, 34.8, 13.0%), cyclophosphamide (30.8, 7.7, 23.1, 7.7%), doxorubicin (25.0, 8.3, 21.7, 6.7%), vinblastine and prednisone (25.0; 5.0; 22.5; 7.5%). Absolute normoblastemia was very severe (&gt;1.0\u2009\u00d7\u200910<jats:sup>3<\/jats:sup> <jats:styled-content style=\"fixed-case\">nRBC\u2009\u00b5L<\/jats:styled-content><jats:sup>\u22121<\/jats:sup>) after administration of vincristine (9.6%), doxorubicin (3.3%), vinblastine and prednisone (2.5%). Absolute normoblastemia negatively correlated with <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> counts (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and positively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) with reticulocyte and <jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content> counts, but correlation coefficients were low (\u22120.19, 0.37, 0.15). Vincristine, doxorubicin or vinblastine and prednisone may induce severe normoblastemia. This may increase <jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content> counts and mask neutropenia associated with chemotherapy.<\/jats:p>","DOI":"10.1111\/vco.12156","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T06:32:59Z","timestamp":1435213979000},"page":"215-225","source":"Crossref","is-referenced-by-count":15,"title":["Nucleated erythrocytes in blood smears of dogs undergoing chemotherapy"],"prefix":"10.1111","volume":"15","author":[{"given":"P.","family":"Moretti","sequence":"first","affiliation":[{"name":"Department of Veterinary Sciences and Public Health University of Milan  Milan Italy"},{"name":"Central Laboratory, University Teaching Hospital University of Milan  Lodi Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Giordano","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences and Public Health University of Milan  Milan Italy"},{"name":"Central Laboratory, University Teaching Hospital University of Milan  Lodi Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Stefanello","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences and Public Health University of Milan  Milan Italy"},{"name":"Central Laboratory, University Teaching Hospital University of Milan  Lodi Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences and Public Health University of Milan  Milan Italy"},{"name":"Central Laboratory, University Teaching Hospital University of Milan  Lodi Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Castellano","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences and Public Health University of Milan  Milan 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