{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:16:37Z","timestamp":1791980197969,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T00:00:00Z","timestamp":1444780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"Abstract<\/jats:title>\n \n Richter's syndrome (\n RS<\/jats:styled-content>\n ) is the development of an aggressive lymphoma in patients with chronic lymphocytic leukaemia (\n CLL<\/jats:styled-content>\n ). In humans,\n RS<\/jats:styled-content>\n occurs in 2\u201320% of\n CLL<\/jats:styled-content>\n , which transform into diffuse large B\u2010cell lymphoma but reports in dogs are scarce. This study retrospectively describes eight dogs with\n CLL<\/jats:styled-content>\n progressing into\n RS<\/jats:styled-content>\n . A database including 153 dogs with\n CLL<\/jats:styled-content>\n (93T\n CD8<\/jats:styled-content>\n + and 55 B\u2010\n CLL<\/jats:styled-content>\n ) was interrogated and\n RS<\/jats:styled-content>\n was demonstrated in eight cases (representing 5.2% of total\n CLL<\/jats:styled-content>\n ): two with T\u2010cell (2.2% of T\n CLL<\/jats:styled-content>\n ) and six with a B\u2010cell immunophenotype (10.9% of B\u2010\n CLL<\/jats:styled-content>\n ). When\n RS<\/jats:styled-content>\n occurred, lymphocytes were decreased compared to\n CLL<\/jats:styled-content>\n . Five dogs had anaemia and two dogs thrombocytopenia. Frequent clinical signs included lymph node swelling, coughing, vomiting, neurological signs and weight loss. Independently from the therapy,\n RS<\/jats:styled-content>\n was associated with a short survival (median 41 days).\n RS<\/jats:styled-content>\n should be considered as an unfavourable evolution in canine\n CLL<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1111\/vco.12172","type":"journal-article","created":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T05:10:15Z","timestamp":1444799415000},"page":"366-373","source":"Crossref","is-referenced-by-count":16,"title":["Chronic lymphocytic leukemia transformation into high\u2010grade lymphoma: a description of Richter's syndrome in eight dogs"],"prefix":"10.1111","volume":"15","author":[{"given":"S.","family":"Comazzi","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Veterinarie e Sanit\u00e0 Pubblica Universit\u00e0 degli Studi di Milano Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9882-2867","authenticated-orcid":false,"given":"V.","family":"Martini","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Veterinarie e Sanit\u00e0 Pubblica Universit\u00e0 degli Studi di Milano Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Riondato","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Veterinarie Universit\u00e0 degli Studi di Torino Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Poggi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Veterinarie Universit\u00e0 degli Studi di Torino Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Stefanello","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Veterinarie e Sanit\u00e0 Pubblica Universit\u00e0 degli Studi di Milano Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Marconato","sequence":"additional","affiliation":[{"name":"Centro Oncologico Veterinario Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Albonico","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Veterinarie e Sanit\u00e0 Pubblica Universit\u00e0 degli Studi di Milano Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. E.","family":"Gelain","sequence":"additional","affiliation":[{"name":"Dipartimento di Biomedicina Comparata e Alimentazione Universit\u00e0 degli Studi di Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,14]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"35","article-title":"Risk for second nonlymphoid neoplasms in chronic lymphocytic leukemia","volume":"9","author":"Dasanu CA","year":"2007","journal-title":"MedGenMed"},{"key":"e_1_2_6_3_1","first-page":"1","article-title":"Richter syndrome in chronic lymphocytic leukemia: updates on biology, clinical features and therapy","volume":"21","author":"Jamroziak K1","year":"2015","journal-title":"Leukemia & Lymphoma"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03220.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V58.1.183.183"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.880"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(03)00120-7"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.2460\/javma.1986.189.02.214","article-title":"Chronic lymphocytic leukemia in the dog: 22 cases (1974\u20131984)","volume":"189","author":"Leifer CE","year":"1986","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.11-0453"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2010.0640.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2007.09.018"},{"key":"e_1_2_6_12_1","first-page":"152","volume-title":"Schalm's Veterinary Hematology","author":"Tvedten H","year":"2010"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.40-1-32"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07248.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn090"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20773"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200407000-00002"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2010.03.011"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-8051-8_8"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2008.00099.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12048"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2003.10.009"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvco.12172","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvco.12172","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12172","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vco.12172","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T21:11:54Z","timestamp":1748639514000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.12172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,14]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/vco.12172"],"URL":"https:\/\/doi.org\/10.1111\/vco.12172","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,14]]}}}