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The medical records of 11 client\u2010owned dogs undergoing palliative treatment for primary bone tumors with known or suspected pamidronate extravasation reactions were reviewed. The majority of adverse events were low grade in nature, however in some cases, the reactions were severe and led to euthanasia in one instance. Time to complete resolution of lesions ranged from within several days to greater than one and a half months. Aside from the dog that was euthanized, no long\u2010term sequelae of extravasation were identified. Treatments employed to address the reactions varied widely. Pamidronate extravasation reaction appears to be an uncommon, but potentially serious complication of intravenous administration.<\/jats:p>","DOI":"10.1111\/vco.12191","type":"journal-article","created":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T05:13:06Z","timestamp":1463116386000},"page":"470-480","source":"Crossref","is-referenced-by-count":4,"title":["Extravasation reactions associated with the administration of pamidronate: 11 cases (2008\u20132013)"],"prefix":"10.1111","volume":"15","author":[{"given":"B. A.","family":"Marker","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Cummings School of Veterinary Medicine Tufts University  North Grafton MA 01536 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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