{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:32:59Z","timestamp":1792027979988,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T00:00:00Z","timestamp":1458604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To describe the results of electrochemotherapy (<jats:styled-content style=\"fixed-case\">ECT<\/jats:styled-content>) in dogs with mast cell tumours (<jats:styled-content style=\"fixed-case\">MCTs<\/jats:styled-content>) either as first line therapy or as an adjuvant to surgery. The treatment combines administration of low dose chemotherapeutic drugs with the application of microsecond electric pulses, which cause the temporary permeabilization and increased porosity of the tumour cell membranes. The design of this study is a retrospective case series. A total of 51 dogs with <jats:styled-content style=\"fixed-case\">MCTs<\/jats:styled-content> were included and classified according to <jats:styled-content style=\"fixed-case\">ECT<\/jats:styled-content> procedure into 4 groups (<jats:styled-content style=\"fixed-case\">ECT<\/jats:styled-content> only, 15 cases, intra\u2010surgery <jats:styled-content style=\"fixed-case\">ECT<\/jats:styled-content>, 11, <jats:styled-content style=\"fixed-case\">ECT<\/jats:styled-content> Adjuvant to surgery, 14, Surgery followed by <jats:styled-content style=\"fixed-case\">ECT<\/jats:styled-content>, 11). The four groups (staged with location, size and grade) were evaluated to assess complete or partial remission, disease free interval, overall survival time and local toxicity. In this case series, Boxers, mixed breed and Labrador Retrievers, male dogs, between 4 and 9 years old were more represented. <jats:styled-content style=\"fixed-case\">MCTs<\/jats:styled-content> were predominantly grade 2 (Patnaik) and T stage 0\u20131, I\u20101 (<jats:styled-content style=\"fixed-case\">World Health Organization<\/jats:styled-content>). Treated lesions were most commonly identified on the hindlimb and head where curative surgery would involve cosmetic or functional compromise. The intra\u2010surgery group of dogs showed the best disease free interval with Kaplan\u2013Meyer analysis. Local toxicity induced by <jats:styled-content style=\"fixed-case\">ECT<\/jats:styled-content> ranged mostly from 1 to 4 in a 5\u2010point arbitrary scale with 0\u00a0\u2013\u00a0no toxicity to 5\u00a0\u2013\u00a0highest toxicity. In this study, <jats:styled-content style=\"fixed-case\">ECT<\/jats:styled-content> can be applied successfully as an exclusive therapy in smaller <jats:styled-content style=\"fixed-case\">MCTs<\/jats:styled-content> as an alternative to surgery. <jats:styled-content style=\"fixed-case\">ECT<\/jats:styled-content> can be combined with surgery either intra\u2010operatively or post operatively for larger lesions without significant toxicity.<\/jats:p>","DOI":"10.1111\/vco.12217","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T12:11:19Z","timestamp":1458648679000},"page":"775-784","source":"Crossref","is-referenced-by-count":54,"title":["The treatment of canine mast cell tumours with electrochemotherapy with or without surgical excision"],"prefix":"10.1111","volume":"15","author":[{"given":"R.","family":"Lowe","sequence":"first","affiliation":[{"name":"Ashleigh Veterinary Clinic Limited  Knaresborough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gavazza","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Impellizeri","sequence":"additional","affiliation":[{"name":"Veterinary Oncology Services  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M.","family":"Soden","sequence":"additional","affiliation":[{"name":"Cork Cancer Research Centre University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Lubas","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcsup.2006.08.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.55.4634"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0117.x"},{"key":"e_1_2_6_5_1","first-page":"3524","article-title":"Electrochemical therapy to treat cancer (in vivo treatment)","volume":"2007","author":"Tello M","year":"2007","journal-title":"Conference Proceeding: Annual International Conference of the IEEE Engineering 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