{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:58:30Z","timestamp":1777535910914,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T00:00:00Z","timestamp":1462147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","award":["LLS 7004\u201311"],"award-info":[{"award-number":["LLS 7004\u201311"]}],"id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["NIH\u2010R01\u2010CA197844\u201001"],"award-info":[{"award-number":["NIH\u2010R01\u2010CA197844\u201001"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">OSU\u20102S<\/jats:styled-content> is a <jats:styled-content style=\"fixed-case\">FTY720<\/jats:styled-content> (Fingolimod) derivative that lacks immunosuppressive properties but exhibits strong anti\u2010tumour activity in several haematological and solid tumour models. We have recently shown <jats:styled-content style=\"fixed-case\">OSU\u20102S<\/jats:styled-content> to mediate potent cytotoxicity in human mantle cell lymphoma cell lines and primary cells. We report here the pre\u2010clinical activity of <jats:styled-content style=\"fixed-case\">OSU\u20102S<\/jats:styled-content> in spontaneous B\u2010cell lymphoma of dogs which shares many characteristics of human lymphoma. <jats:styled-content style=\"fixed-case\">OSU\u20102S<\/jats:styled-content> mediated apoptosis in canine B\u2010cell lines and primary B\u2010cell lymphoma cells obtained from spontaneous lymphoma bearing dogs. <jats:styled-content style=\"fixed-case\">OSU\u20102S<\/jats:styled-content> induced reactive oxygen species (<jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>) in canine lymphoma cells and inhibition of <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content> partially rescued <jats:styled-content style=\"fixed-case\">OSU\u20102S<\/jats:styled-content>\u2010mediated cell death. These studies provide a rational basis for the use of spontaneous lymphoma in pet dogs as a preclinical large animal model for the development of <jats:styled-content style=\"fixed-case\">OSU\u20102S<\/jats:styled-content> as small molecule for treating people and dogs with lymphoma.<\/jats:p>","DOI":"10.1111\/vco.12221","type":"journal-article","created":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T16:26:58Z","timestamp":1462206418000},"page":"1115-1118","source":"Crossref","is-referenced-by-count":7,"title":["Non\u2010immunosuppressive <scp>FTY720<\/scp>\u2010derivative <scp>OSU\u20102S<\/scp> mediates reactive oxygen species\u2010mediated cytotoxicity in canine B\u2010cell lymphoma"],"prefix":"10.1111","volume":"15","author":[{"given":"R.","family":"Mani","sequence":"first","affiliation":[{"name":"Comprehensive Cancer Center The Ohio State University  Columbus OH USA"},{"name":"Department of Veterinary Biosciences, College of Veterinary Medicine The Ohio State University  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Yan","sequence":"additional","affiliation":[{"name":"Division of Medicinal Chemistry, College of Pharmacy The Ohio State University  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Mo","sequence":"additional","affiliation":[{"name":"Center for Biostatistics The Ohio State University  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u2010S.","family":"Chen","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center The Ohio State University  Columbus OH USA"},{"name":"Department of Veterinary Biosciences, College of Veterinary Medicine The Ohio State University  Columbus OH USA"},{"name":"Division of Medicinal Chemistry, College of Pharmacy The Ohio State University  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Phelps","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutics, College of Pharmacy The Ohio State University  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Klisovic","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, College of Medicine The Ohio State University  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"Byrd","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center The Ohio State University  Columbus OH USA"},{"name":"Department of Veterinary Biosciences, College of Veterinary Medicine The Ohio State University  Columbus OH USA"},{"name":"Division of Medicinal Chemistry, College of Pharmacy The Ohio State University  Columbus OH USA"},{"name":"Division of Hematology, Department of Internal Medicine, College of Medicine The Ohio State University  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. C.","family":"Kisseberth","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center The Ohio State University  Columbus OH USA"},{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine The Ohio State University  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. A.","family":"London","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center The Ohio State University  Columbus OH USA"},{"name":"Department of Veterinary Biosciences, College of Veterinary Medicine The Ohio State University  Columbus OH USA"},{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine The Ohio State University  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Muthusamy","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center The Ohio State University  Columbus OH USA"},{"name":"Department of Veterinary Biosciences, College of Veterinary Medicine The Ohio State University  Columbus OH USA"},{"name":"Division of Hematology, Department of Internal Medicine, College of Medicine The Ohio State University  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985813478210"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/07357900009012210"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2011.02.004"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2014.02.016"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24293"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI68951"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.199"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2015.04.008"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040078"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00205629"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2007.06.007"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2014.06.001"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvco.12221","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvco.12221","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T19:48:57Z","timestamp":1696016937000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.12221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,2]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/vco.12221"],"URL":"https:\/\/doi.org\/10.1111\/vco.12221","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,2]]}}}