{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:22:57Z","timestamp":1787016177524,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,19]],"date-time":"2016-05-19T00:00:00Z","timestamp":1463616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NCSU Cancer Genomics Fund (M. B.)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The aim of this study was to evaluate the relationship between breed and the histopathological grade of canine mast cell tumours (\n                    <jats:styled-content style=\"fixed-case\">MCTs<\/jats:styled-content>\n                    ). A retrospective survey of pathology data of 9375 histopathologically confirmed diagnoses of cutaneous\n                    <jats:styled-content style=\"fixed-case\">MCTs<\/jats:styled-content>\n                    in the\n                    <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>\n                    was evaluated in the context of breed prevalence in over two million registered purebred dogs. Association of histopathological grade with breed, age, sex and spay\/neuter status was assessed. The data indicate that the proportion of high\u2010grade tumours increases with advancing age, and that male and intact dogs have increased odds of developing high\u2010grade tumours. A significant difference in the proportion of high\u2010grade tumours between breeds was detected. The Pug was at significantly increased risk of developing low\/intermediate\u2010grade tumours, but not high\u2010grade tumours, resulting in preponderance of less aggressive\n                    <jats:styled-content style=\"fixed-case\">MCTs<\/jats:styled-content>\n                    in this breed. The results of this study suggest a genetic association for the development of high\u2010grade\n                    <jats:styled-content style=\"fixed-case\">MCTs<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/vco.12225","type":"journal-article","created":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T09:44:41Z","timestamp":1463823881000},"page":"829-839","source":"Crossref","is-referenced-by-count":51,"title":["Association of breed and histopathological grade in canine mast cell tumours"],"prefix":"10.1111","volume":"15","author":[{"given":"H.","family":"Mochizuki","sequence":"first","affiliation":[{"name":"Department of Molecular Biomedical Sciences, College of Veterinary Medicine North Carolina State University  Raleigh NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Motsinger\u2010Reif","sequence":"additional","affiliation":[{"name":"Bioinformatics Research Center, Department of Statistics North Carolina State University  Raleigh NC USA"},{"name":"Comparative Medicine Institute North Carolina State University  Raleigh NC USA"},{"name":"Center for Human Health and the Environment North Carolina State University  Raleigh NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bettini","sequence":"additional","affiliation":[{"name":"American Kennel Club  Raleigh NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Moroff","sequence":"additional","affiliation":[{"name":"Antech Diagnostics Inc.  New Hyde Park NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Breen","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedical Sciences, College of Veterinary Medicine North Carolina State University  Raleigh NC USA"},{"name":"Comparative Medicine Institute North Carolina State University  Raleigh NC USA"},{"name":"Center for Human Health and the Environment North Carolina State University  Raleigh NC USA"},{"name":"Lineberger Comprehensive Cancer Center University of North Carolina  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1979.tb07068.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1987.tb09673.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.239.7.960"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2008.00694.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588402100503"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810386469"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985814521638"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2012.11.018"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.154.24.743"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/2052-6687-2-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2013.02.017"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-5621"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5810.2006.00085.x"},{"key":"e_1_2_8_15_1","first-page":"435","article-title":"Canine mastocytoma: excess risk as related to ancestry","volume":"42","author":"Peters JA","year":"1969","journal-title":"Journal of the National Cancer Institute"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1973.tb06891.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2007.02.003"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810387446"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1958.tb13802.x"},{"key":"e_1_2_8_20_1","first-page":"335","volume-title":"Withrow and MacEwen's Small Animal Clinical Oncology","author":"London C","year":"2012"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08837"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0962-1083.2001.01452.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005647"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01645.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00969.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063870501700305"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvco.12225","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvco.12225","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T15:45:30Z","timestamp":1696002330000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.12225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,19]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/vco.12225"],"URL":"https:\/\/doi.org\/10.1111\/vco.12225","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,19]]}}}