{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T05:49:21Z","timestamp":1789364961005,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T00:00:00Z","timestamp":1462147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Canine Cancer Genomics Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Follicular lymphomas (\n                    <jats:styled-content style=\"fixed-case\">FLs<\/jats:styled-content>\n                    ) typically exhibit a chromosome translocation that induces constitutive expression of the anti\u2010apoptotic bcl2 protein and accumulation of additional molecular defects. This rearrangement offers a promising therapeutic target, but its nature as a fundamental driver of\n                    <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>\n                    pathogenesis remains unclear as 15% of cases lack the translocation. We performed an integrated immunohistochemical and genomic investigation of 10 naturally occurring\n                    <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>\n                    cases from domestic dogs, showing that, as with human tumours, they exhibit marked heterogeneity in the frequency and intensity of bcl2 protein expression. Genomic copy number aberrations were infrequent and broadly consistent with those of other canine B\u2010cell lymphoma subtypes. None of the canine\n                    <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>\n                    specimens exhibited a rearrangement consistent with the hallmark translocation of human\n                    <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>\n                    , despite their remarkable histomorphologic similarity. Parallel exploration of canine and human cases may reveal alternative tumour\u2010initiating mechanisms other than\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">BCL2<\/jats:styled-content>\n                    <\/jats:italic>\n                    disruption, yielding a more complete definition of the molecular pathogenesis of\n                    <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/vco.12227","type":"journal-article","created":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T12:26:54Z","timestamp":1462192014000},"page":"852-867","source":"Crossref","is-referenced-by-count":13,"title":["Integrated immunohistochemical and\n                    <scp>DNA<\/scp>\n                    copy number profiling analysis provides insight into the molecular pathogenesis of\u00a0canine follicular lymphoma"],"prefix":"10.1111","volume":"15","author":[{"given":"R.","family":"Thomas","sequence":"first","affiliation":[{"name":"Department of Molecular Biomedical Sciences, College of Veterinary Medicine North Carolina State University  Raleigh NC USA"},{"name":"Center for Comparative Medicine and Translational Research North Carolina State University  Raleigh NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Demeter","sequence":"additional","affiliation":[{"name":"Veterinary Diagnostic Laboratory, College of Veterinary Medicine University of Illinois  Urbana IL USA"},{"name":"IDEXX Reference Laboratories Inc.  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