{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:04:06Z","timestamp":1792015446305,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T00:00:00Z","timestamp":1466640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007709","name":"Michigan State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007709","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","award":["D08CA\u2010308"],"award-info":[{"award-number":["D08CA\u2010308"]}],"id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Canine histiocytic sarcoma (<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>) is an aggressive neoplasia with variable clinical course and fatal outcome. The goals of this study were to evaluate a large cohort of canine patients with immunohistochemically confirmed<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>and identify clinical prognostic factors. Biopsy submissions to the Michigan State University with tentative<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>diagnoses were histologically and immunohistochemically confirmed, medical records collected, and interviews with relevant veterinary clinics conducted. Of 1391 histopathology submissions with a diagnosis containing the word \u2018histiocytic\u2019, 335 were suspicious for malignancy, and 180 were consistent with<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>and had adequate clinical information recorded. The most commonly represented breeds were Bernese mountain dogs (<jats:italic>n<\/jats:italic>\u2009=\u200953), labrador retrievers (<jats:italic>n<\/jats:italic>\u2009=\u200926) and golden retrievers (<jats:italic>n<\/jats:italic>\u2009=\u200917). Median survival for all dogs in the study was 170 days, and subgroup analysis identified palliative treatment, disseminated<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>, and concurrent use of corticosteroids as statistically significant negative factors for survival, in both uni\u2010 and multi\u2010variate methodologies.<\/jats:p>","DOI":"10.1111\/vco.12252","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T18:28:26Z","timestamp":1466706506000},"page":"1171-1180","source":"Crossref","is-referenced-by-count":47,"title":["Clinical prognostic factors in canine histiocytic sarcoma"],"prefix":"10.1111","volume":"15","author":[{"given":"N. 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