{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:14Z","timestamp":1787016074085,"version":"build-2736575974"},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T00:00:00Z","timestamp":1470700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P 21173\u2010B13"],"award-info":[{"award-number":["P 21173\u2010B13"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["F 4704\u2010B20"],"award-info":[{"award-number":["F 4704\u2010B20"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>CD30 is a novel therapeutic target in human mast cell (MC) neoplasms. In this \u2018comparative oncology\u2019 study, we examined CD30 expression and regulation in neoplastic canine MC using a panel of immunomodulatory cytokines [interleukin\u20102 (IL\u20102), IL\u20104, IL\u20105, IL\u20106, IL\u201013 and stem cell factor (SCF)] and the canine mastocytoma cell lines NI\u20101 and C2. Of all cytokines tested IL\u20104 was found to downregulate expression of CD30 in NI\u20101 and C2 cells. We also found that the CD30\u2010targeting antibody\u2010conjugate brentuximab vedotin induces growth inhibition and apoptosis in both MC lines. Next, we asked whether IL\u20104\u2010induced downregulation of CD30 interferes with brentuximab vedotin\u2010effects. Indeed, pre\u2010incubation of NI\u20101 cells with IL\u20104 decreased responsiveness towards brentuximab vedotin. To overcome IL\u20104\u2010mediated resistance, we applied drug combinations and found that brentuximab vedotin synergizes with the Kit\u2010targeting drugs masitinib and PKC412 in inhibiting growth of NI\u20101 and C2 cells. In summary, CD30 is a new marker and IL\u20104\u2010regulated target in neoplastic canine MC.<\/jats:p>","DOI":"10.1111\/vco.12260","type":"journal-article","created":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T22:02:45Z","timestamp":1470780165000},"page":"1240-1256","source":"Crossref","is-referenced-by-count":14,"title":["IL\u20104 downregulates expression of the target receptor CD30 in neoplastic canine mast cells"],"prefix":"10.1111","volume":"15","author":[{"given":"K.","family":"Bauer","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I, Division of Hematology and Hemostaseology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Hadzijusufovic","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Hematology and Hemostaseology Medical University of Vienna  Vienna Austria"},{"name":"Ludwig Boltzmann Cluster Oncology Medical University of 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