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With the aim of estimating the late toxicity risk profile for various tumour sizes and locations, the present paper evaluates the normal tissue complication probability (<jats:styled-content style=\"fixed-case\">NTCP<\/jats:styled-content>) values for the intracranial organs at risk. By making isoeffect calculations, a new 10\u2010fraction radiation protocol was developed with the same tumour control probability (<jats:styled-content style=\"fixed-case\">TCP<\/jats:styled-content>) as a currently used 20\u2010fraction standard protocol, and complication risk profiles for brain, brainstem and optic chiasm were modelled using a representative population of 64 dogs with brain tumours. For &gt;59% of cases, the new 10\u2010fraction protocol yielded an acceptable, low risk estimate of late toxicity (&lt;10%). Our calculations suggest that it may be safe to treat small to intermediate\u2010sized tumours that are neither located near the optic chiasm nor at the brainstem with 10 daily fractions of 4.35\u2009Gy.<\/jats:p>","DOI":"10.1111\/vco.12265","type":"journal-article","created":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T06:05:28Z","timestamp":1472623528000},"page":"1295-1308","source":"Crossref","is-referenced-by-count":16,"title":["A complication probability planning study to predict the safety of a new protocol for intracranial tumour radiotherapy in dogs"],"prefix":"10.1111","volume":"15","author":[{"given":"C.","family":"Rohrer Bley","sequence":"first","affiliation":[{"name":"Division of Radiation Oncology Vetsuisse Faculty, University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Meier","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology Vetsuisse Faculty, University of Zurich Zurich 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