{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T02:33:44Z","timestamp":1787625224754,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,10,9]],"date-time":"2016-10-09T00:00:00Z","timestamp":1475971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Leukocyte ratios correlate with outcome in several human cancers. Little is known about their prognostic significance in mast cell tumour (<jats:styled-content style=\"fixed-case\">MCT<\/jats:styled-content>). The aim of the study was to evaluate the prognostic significance of pretreatment leukocyte concentrations and their ratios in dogs with <jats:styled-content style=\"fixed-case\">MCT<\/jats:styled-content> for survival. Medical records of 92 dogs with <jats:styled-content style=\"fixed-case\">MCT<\/jats:styled-content> were retrospectively reviewed. Tumour diagnosis was made by tumour biopsy or fine\u2010needle aspirate. Only dogs without prior treatment were included. Eosinophil, lymphocyte, monocyte and neutrophil concentration were obtained by <jats:styled-content style=\"fixed-case\">ADVIA<\/jats:styled-content> 2120\u2122 (Siemens Healthcare, Vienna, Austria). Neutrophil\u2010to\u2010eosinophil ratio (<jats:styled-content style=\"fixed-case\">NER<\/jats:styled-content>), lymphocyte\u2010to\u2010monocyte ratio (<jats:styled-content style=\"fixed-case\">LMR<\/jats:styled-content>) and neutrophil\u2010to\u2010lymphocyte ratio (<jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content>) were calculated from collected leukocyte concentrations. Relative eosinophil concentration (<jats:styled-content style=\"fixed-case\">REC<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">NER<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) and <jats:styled-content style=\"fixed-case\">LMR<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) were significant prognostic factors for outcome in univariate analysis. <jats:styled-content style=\"fixed-case\">REC<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009=\u20090.008) and <jats:styled-content style=\"fixed-case\">NER<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) remained independent predictors of survival in multiple analyses. Leukocyte concentrations and ratios, especially <jats:styled-content style=\"fixed-case\">REC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NER<\/jats:styled-content> may serve as prognostic indicators in <jats:styled-content style=\"fixed-case\">MCT<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/vco.12274","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T08:04:17Z","timestamp":1476345857000},"page":"1333-1345","source":"Crossref","is-referenced-by-count":40,"title":["Pretreatment leukocyte ratios and concentrations as predictors of outcome in dogs with cutaneous mast cell tumours"],"prefix":"10.1111","volume":"15","author":[{"given":"O.","family":"Skor","sequence":"first","affiliation":[{"name":"Department for Companion Animals and Horses University of Veterinary Medicine  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Fuchs\u2010Baumgartinger","sequence":"additional","affiliation":[{"name":"Department for Pathobiology University of Veterinary Medicine  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tichy","sequence":"additional","affiliation":[{"name":"Department for Biomedical Sciences University of Veterinary Medicine  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kleiter","sequence":"additional","affiliation":[{"name":"Department for Companion Animals and Horses University of Veterinary Medicine  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Schwendenwein","sequence":"additional","affiliation":[{"name":"Department for Pathobiology University of Veterinary Medicine  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2012.00341.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(03)00003-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2011.00301.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588402100503"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810386469"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.46-2-362"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12029"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12320"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2012.11.018"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2015.05.002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12140"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.088161"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-009-9335-4"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-3845"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju124"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2015.10.003"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.116392"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2014.11.001"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07205"},{"issue":"3","key":"e_1_2_7_21_1","first-page":"A255","article-title":"Neutrophil\u2010to\u2010eosinophil ratio predicts mortality in patients with advanced heart failure","volume":"6","author":"Nagarajan V","year":"2013","journal-title":"Circulation. 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