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Fifty cases of canine mast cell tumours (<jats:styled-content style=\"fixed-case\">MCT<\/jats:styled-content>) were retrospectively evaluated and submitted to immunohistochemistry for <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102, <jats:styled-content style=\"fixed-case\">CD31<\/jats:styled-content>, Ki\u201067, <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content>\u2010387 and <jats:styled-content style=\"fixed-case\">CD3<\/jats:styled-content>. Furthermore its relationship with clinicopathological variables and overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) was analysed. <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 intensity (<jats:italic>P<\/jats:italic>\u2009=\u20090.016), but not <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 extension nor score was associated with decreased <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> and higher grades of malignancy according to Patnaik (<jats:italic>P<\/jats:italic>\u2009=\u20090.002) and Kiupel (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) grading systems. Cox\u20102 intensity was also associated with higher Ki\u201067 scores (<jats:italic>P<\/jats:italic>\u2009=\u20090.009), higher mitotic index (<jats:italic>P<\/jats:italic>\u2009=\u20090.022) and higher microvascularization density (<jats:italic>P<\/jats:italic>\u2009=\u20090.045). No association was observed for <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 intensity and <jats:styled-content style=\"fixed-case\">CD3<\/jats:styled-content>\u2010T lymphocyte (<jats:italic>P<\/jats:italic>\u2009=\u20090.377) and macrophage infiltration (<jats:italic>P<\/jats:italic>\u2009=\u20090.261) by <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content>\u2010387 immunollabelling, suggesting an active role of <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 in <jats:styled-content style=\"fixed-case\">MCT<\/jats:styled-content> oncogenesis mainly through proliferation and angiogenesis stimulation making it a potentially clinical relevant prognosis marker and therapeutic target.<\/jats:p>","DOI":"10.1111\/vco.12280","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T10:16:32Z","timestamp":1478513792000},"page":"1382-1392","source":"Crossref","is-referenced-by-count":18,"title":["High <scp>COX<\/scp>\u20102 expression in canine mast cell tumours is associated with proliferation, angiogenesis and decreased overall survival"],"prefix":"10.1111","volume":"15","author":[{"given":"H.","family":"Greg\u00f3rio","sequence":"first","affiliation":[{"name":"CHV Centro Hospitalar Veterin\u00e1rio  Porto Portugal"},{"name":"Department of Veterinary Sciences University of Tr\u00e1s\u2010os\u2010Montes and Alto Douro  Vila Real Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Raposo","sequence":"additional","affiliation":[{"name":"Division of Cancer and Stem Cells, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. 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