{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:27:51Z","timestamp":1790623671431,"version":"4.1.0"},"reference-count":98,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T00:00:00Z","timestamp":1485302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Pheochromocytomas (\n                    <jats:styled-content style=\"fixed-case\">PCCs<\/jats:styled-content>\n                    ) and paragangliomas (\n                    <jats:styled-content style=\"fixed-case\">PGLs<\/jats:styled-content>\n                    ) are described in several species. In humans and dogs they have many similarities: the excessive catecholamine release in hormonally active\n                    <jats:styled-content style=\"fixed-case\">PCC<\/jats:styled-content>\n                    causes similar clinical signs, the frequency of metastasis is similar, and they are histopathologically almost identical. Surgery is curative when\n                    <jats:styled-content style=\"fixed-case\">PCC<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">PGL<\/jats:styled-content>\n                    have not metastasized, while only palliative treatment is possible for patients with metastatic disease. Mutations in succinate dehydrogenase subunit B (\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">SDHB<\/jats:styled-content>\n                    <\/jats:italic>\n                    ) are associated with metastatic behaviour in human\n                    <jats:styled-content style=\"fixed-case\">PCC<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">PGL<\/jats:styled-content>\n                    and the same mutation has been described in dogs. The dog might therefore be a suitable model for study of the pathogenesis of metastatic\n                    <jats:styled-content style=\"fixed-case\">PCC<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">PGL<\/jats:styled-content>\n                    in humans. Further molecular studies of common tumourigenic pathways and comparative studies of histopathology of human and canine\n                    <jats:styled-content style=\"fixed-case\">PCC<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">PGL<\/jats:styled-content>\n                    are warranted.\n                  <\/jats:p>","DOI":"10.1111\/vco.12291","type":"journal-article","created":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T04:42:59Z","timestamp":1485319379000},"page":"1158-1170","source":"Crossref","is-referenced-by-count":59,"title":["Pheochromocytomas and paragangliomas in humans and dogs"],"prefix":"10.1111","volume":"15","author":[{"given":"S.","family":"Galac","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine Utrecht University Utrecht The 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