{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:53:12Z","timestamp":1763747592214,"version":"3.41.0"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T00:00:00Z","timestamp":1487030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sterile haemorrhagic cystitis (<jats:styled-content style=\"fixed-case\">SHC<\/jats:styled-content>) is a known risk of cyclophosphamide treatment. Diuresis using furosemide is effective in canines when maximally tolerated dosed cyclophosphamide is administered. This retrospective study aimed to determine whether orally administered furosemide decreased the incidence of<jats:styled-content style=\"fixed-case\">SHC<\/jats:styled-content>. Secondary aims were to identify predisposing factors for<jats:styled-content style=\"fixed-case\">SHC<\/jats:styled-content>. One\u2010hundred and fifteen dogs treated with metronomic cyclophosphamide were analysed retrospectively. Populations were not randomized. 25 dogs (21.7%) developed<jats:styled-content style=\"fixed-case\">SHC<\/jats:styled-content>. Furosemide administration significantly reduced the likelihood of<jats:styled-content style=\"fixed-case\">SHC<\/jats:styled-content>development (<jats:italic>P<\/jats:italic>\u2009=\u20090.010, where<jats:styled-content style=\"fixed-case\">SHC<\/jats:styled-content>was diagnosed in 30.3% of dogs administered cyclophosphamide without furosemide, and 10.2% of dogs administered cyclophosphamide with furosemide). Age, gender, breed, bodyweight, number of cyclophosphamide treatments, piroxicam use and previous or pre\u2010existing disease were not found to be associated with<jats:styled-content style=\"fixed-case\">SHC<\/jats:styled-content>development. This study demonstrates furosemide is effective in the prevention of<jats:styled-content style=\"fixed-case\">SHC<\/jats:styled-content>and its use may be considered when implementing metronomic cyclophosphamide therapy.<\/jats:p>","DOI":"10.1111\/vco.12292","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T08:57:08Z","timestamp":1487062628000},"page":"1468-1478","source":"Crossref","is-referenced-by-count":15,"title":["Furosemide for prevention of cyclophosphamide\u2010associated sterile haemorrhagic cystitis in dogs receiving metronomic low\u2010dose oral cyclophosphamide"],"prefix":"10.1111","volume":"15","author":[{"given":"L.","family":"Setyo","sequence":"first","affiliation":[{"name":"Perth Veterinary Oncology Perth Veterinary Specialists Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ma","sequence":"additional","affiliation":[{"name":"Perth Veterinary Oncology Perth Veterinary Specialists Perth 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