{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:36:53Z","timestamp":1789979813159,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T00:00:00Z","timestamp":1494201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Dutch Cancer Society research","award":["UU 2014 7075"],"award-info":[{"award-number":["UU 2014 7075"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>A \u201cmicrobrachytherapy\u201d was developed as treatment option for inoperable tumours by direct intratumoral injection of radioactive holmium\u2010166 (<jats:styled-content style=\"fixed-case\">\n<jats:sup>166<\/jats:sup>Ho<\/jats:styled-content>) microspheres (MS). <jats:styled-content style=\"fixed-case\"><jats:sup>166<\/jats:sup>Ho<\/jats:styled-content> emits \u03b2\u2010radiation which potentially enables a high, ablative, radioactive\u2010absorbed dose on the tumour tissue while sparing surrounding tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials &amp; Methods<\/jats:title><jats:p>Safety and efficacy of <jats:styled-content style=\"fixed-case\"><jats:sup>166<\/jats:sup>Ho<\/jats:styled-content> microbrachytherapy were evaluated in a prospective cohort study of 13 cats with inoperable oral squamous cell carcinoma without evidence of distant metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Local response rate was 55%, including complete response or partial response (downstaging) enabling subsequent marginal resection. Median survival time was 113\u2009days overall, and 296\u2009days for patients with local response. Side effects were minimal. Tumour volume was a significant predictor of response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Response rate may be further improved by optimizing the intratumoral spatial distribution of <jats:styled-content style=\"fixed-case\"><jats:sup>166<\/jats:sup>Ho<\/jats:styled-content> MS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:sup>166<\/jats:sup>Ho<\/jats:styled-content> microbrachytherapy has potential as a minimally invasive, single procedure radio\u2010ablation treatment of unresectable tumours with minimal morbidity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vco.12319","type":"journal-article","created":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T06:13:05Z","timestamp":1494223985000},"page":"114-124","source":"Crossref","is-referenced-by-count":29,"title":["Intratumoral injection of radioactive holmium (<scp><sup>166<\/sup>Ho<\/scp>) microspheres for treatment of oral squamous cell carcinoma in cats"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5366-0120","authenticated-orcid":false,"given":"S. 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