{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:24:15Z","timestamp":1787016255355,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T00:00:00Z","timestamp":1501113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>\n                    Canine T\u2010zone lymphoma (\n                    <jats:styled-content style=\"fixed-case\">TZL<\/jats:styled-content>\n                    ) is a subtype of T\u2010cell lymphoma characterized by unique histologic pattern and cytomorphology, immunophenotypic loss of\n                    <jats:styled-content style=\"fixed-case\">CD45<\/jats:styled-content>\n                    expression, and an indolent clinical behaviour. Dogs with\n                    <jats:styled-content style=\"fixed-case\">TZL<\/jats:styled-content>\n                    typically present with 1 or more enlarged lymph nodes and\/or lymphocytosis. We describe a novel extranodal presentation of\n                    <jats:styled-content style=\"fixed-case\">TZL<\/jats:styled-content>\n                    involving the tongue. Twelve dogs with tongue masses were diagnosed with lingual\n                    <jats:styled-content style=\"fixed-case\">TZL<\/jats:styled-content>\n                    based on a variable combination of immunophenotyping via flow cytometry, cytology, histopathology, immunohistochemistry and\/or\n                    <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\n                    for antigen receptor rearrangement (\n                    <jats:styled-content style=\"fixed-case\">PARR<\/jats:styled-content>\n                    ) assay. Eleven dogs exhibited concurrent lymphocytosis and\/or lymph node enlargement. Three cases were initially diagnosed as plasma cell tumours based on histology alone, thereby revealing a potential diagnostic challenge. Seven dogs achieved clinical remission and 4 achieved stable disease following variable treatment, consistent with the indolent nature of typical\n                    <jats:styled-content style=\"fixed-case\">TZL<\/jats:styled-content>\n                    involving the lymph nodes and peripheral blood. In 1 case the\n                    <jats:styled-content style=\"fixed-case\">TZL<\/jats:styled-content>\n                    resulted in progressive disease and failure to respond to treatment. In this case, the\n                    <jats:styled-content style=\"fixed-case\">TZL<\/jats:styled-content>\n                    exhibited histologic features of a higher grade neoplasm. This case series highlights a unique presentation of\n                    <jats:styled-content style=\"fixed-case\">TZL<\/jats:styled-content>\n                    and identifies a new differential diagnosis for lingual neoplasia. In this study, we characterize the clinical presentation, diagnostic features and patient outcomes of 12 dogs with lingual\n                    <jats:styled-content style=\"fixed-case\">TZL<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/vco.12322","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T04:25:54Z","timestamp":1501215954000},"page":"131-139","source":"Crossref","is-referenced-by-count":23,"title":["Clinicopathologic features of lingual canine T\u2010zone lymphoma"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0903-8278","authenticated-orcid":false,"given":"L. J.","family":"Harris","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. D.","family":"Rout","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. L.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. D.","family":"Labadie","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Boostrom","sequence":"additional","affiliation":[{"name":"Clinical Sciences Department, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. M.","family":"Cannon","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine University of Minnesota  St. Paul Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. R.","family":"Avery","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.J.","family":"Ehrhart","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C.","family":"Avery","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2011.00317.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12343"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12024"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810379428"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810363902"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.43-3-241"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.15-0688"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00833.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12043"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.40-1-32"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci3020011"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2006001"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.136673"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/1042819031000063390"},{"issue":"5","key":"e_1_2_5_16_1","first-page":"459","article-title":"Linfoma malt primario de la lengua [Primary malt lymphoma of the tongue]","volume":"9","author":"Goteri G","year":"2004","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.95195"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.228.10.1533"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.5326\/0440308"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvco.12322","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T15:50:26Z","timestamp":1694965826000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.12322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,27]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/vco.12322"],"URL":"https:\/\/doi.org\/10.1111\/vco.12322","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,27]]}}}