{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:09:09Z","timestamp":1790820549389,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T00:00:00Z","timestamp":1496016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>Feline large granular lymphocyte (<jats:styled-content style=\"fixed-case\">LGL<\/jats:styled-content>) lymphoma is an uncommon subtype of lymphoma characterized by a grave prognosis and scarce response to chemotherapy. There are limited reports on clinico\u2010pathological and prognostic factors. One\u2010hundred and 9 cats with newly diagnosed<jats:styled-content style=\"fixed-case\">LGL<\/jats:styled-content>lymphoma that underwent initial staging (including hematology, serum biochemistry, thoracic radiographs and abdominal ultrasound), and followed\u2010up were retrospectively evaluated.<jats:styled-content style=\"fixed-case\">LGL<\/jats:styled-content>lymphoma was localized within the gastrointestinal tract with or without extra\u2010intestinal involvement in 91.7% of the cases, and at extra\u2010gastrointestinal sites in 8.3%. Symptoms were frequent. Anemia (31.2%) and neutrophilia (26.6%) were commonly observed, and 14 (12.8%) cats had neoplastic circulating cells. Frequent biochemistry abnormalities included elevated<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>(39.4%) and hypoalbuminemia (28.4%). Twenty (54.1%) of 37 cats had elevated serum<jats:styled-content style=\"fixed-case\">LDH<\/jats:styled-content>. Treatment varied among cats, and included surgery (11%), chemotherapy (23%), corticosteroids (38.5%) and no treatment (27.5%). Median time to progression (<jats:styled-content style=\"fixed-case\">MTTP<\/jats:styled-content>) was 5 days, and median survival time (<jats:styled-content style=\"fixed-case\">MST<\/jats:styled-content>) 21 days.<jats:styled-content style=\"fixed-case\">MST<\/jats:styled-content>was significantly shorter in the case of substage b, circulating neoplastic cells, lack of chemotherapy administration, and lack of treatment response. A small subset of cats (7.3%) survived more than 6 months, suggesting that a more favorable clinical course can be found among<jats:styled-content style=\"fixed-case\">LGL<\/jats:styled-content>lymphoma patients.<\/jats:p>","DOI":"10.1111\/vco.12325","type":"journal-article","created":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T10:12:43Z","timestamp":1496052763000},"page":"159-166","source":"Crossref","is-referenced-by-count":46,"title":["Feline large granular lymphocyte lymphoma: An Italian Society of Veterinary Oncology (<scp>SIONCOV<\/scp>) retrospective study"],"prefix":"10.1111","volume":"16","author":[{"given":"R.","family":"Finotello","sequence":"first","affiliation":[{"name":"Small Animal Teaching Hospital, School of Veterinary Sciences University of Liverpool Neston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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