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The disease is treated surgically and wide margins are recommended. Adjuvant chemotherapy and radiotherapy used in this disease cause\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    damage in neoplastic cells, which is aimed to induce apoptotic cell death. Resisting cell death is a hallmark of cancer, which contributes to the development and progression of tumours. The aim of this study was to investigate the expression of the proteins involved in the apoptotic intrinsic pathway and to evaluate their potential use as prognostic markers for canine cutaneous\n                    <jats:styled-content style=\"fixed-case\">MCTs<\/jats:styled-content>\n                    . Immunohistochemistry for\n                    <jats:styled-content style=\"fixed-case\">BAX<\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">BCL2<\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">APAF1<\/jats:styled-content>\n                    , Caspase\u20109, and Caspase\u20103 was performed in 50 canine cases of\n                    <jats:styled-content style=\"fixed-case\">MCTs<\/jats:styled-content>\n                    . High\n                    <jats:styled-content style=\"fixed-case\">BAX<\/jats:styled-content>\n                    expression was associated with higher mortality rate and shorter survival.\n                    <jats:styled-content style=\"fixed-case\">BCL2<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">APAF1<\/jats:styled-content>\n                    expressions offered additional prognostic information to the histopathological grading systems. The present results indicate that variations in the expression of apoptotic proteins are related to malignancy of cutaneous MCTs in dogs.\n                  <\/jats:p>","DOI":"10.1111\/vco.12330","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T04:56:56Z","timestamp":1497329816000},"source":"Crossref","is-referenced-by-count":7,"title":["Apoptotic intrinsic pathway proteins predict survival in canine cutaneous mast cell tumours"],"prefix":"10.1111","volume":"16","author":[{"given":"C. N.","family":"Barra","sequence":"first","affiliation":[{"name":"Departamento de Patologia, Faculdade de Medicina Veterin\u00e1ria e Zootecnia Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Laborat\u00f3rio de Oncologia Comparada e Translacional, Faculdade de Zootecnia e Engenharia de Alimentos Universidade de S\u00e3o Paulo Pirassununga Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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H.","family":"Pulz","sequence":"additional","affiliation":[{"name":"Departamento de Patologia, Faculdade de Medicina Veterin\u00e1ria e Zootecnia Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Laborat\u00f3rio de Oncologia Comparada e Translacional, Faculdade de Zootecnia e Engenharia de Alimentos Universidade de S\u00e3o Paulo Pirassununga Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. C.","family":"Huete","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Oncologia Comparada e Translacional, Faculdade de Zootecnia e Engenharia de Alimentos Universidade de S\u00e3o Paulo Pirassununga Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. R.","family":"Kleeb","sequence":"additional","affiliation":[{"name":"Universidade Metodista de S\u00e3o Paulo S\u00e3o Bernardo do Campo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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