{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:42:44Z","timestamp":1787506964570,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T00:00:00Z","timestamp":1503446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University of Minnesota Animal Cancer Care and Research Program"},{"name":"University of Tennessee Small Animal Clinical Sciences Oncology Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>\n                    Periarticular histiocytic sarcoma (\n                    <jats:styled-content style=\"fixed-case\">PAHS<\/jats:styled-content>\n                    ) is the most common synovial tumour in dogs and is characterized by aggressive local disease with a high rate of distant metastasis. Previously, an association between\n                    <jats:styled-content style=\"fixed-case\">PAHS<\/jats:styled-content>\n                    and prior joint disease has been demonstrated in the Bernese Mountain Dog breed and suggested in the Rottweiler. We hypothesized that this association would be present in other breeds and investigated this via a retrospective, case\u2010controlled analysis. Cases were dogs diagnosed with\n                    <jats:styled-content style=\"fixed-case\">PAHS<\/jats:styled-content>\n                    of the stifle or elbow. Controls were age, breed and sex\u2010matched dogs without a diagnosis of histiocytic sarcoma. Diagnosis of prior joint disease was determined based on review of medical records and direct veterinarian and owner communications. Data were evaluated using logistic regression, 2\u2010sampled\n                    <jats:italic>t<\/jats:italic>\n                    tests, and chi\u2010squared analysis. Our study population consisted of 28 cases and 46 controls, including Flat\u2010Coated, Golden and Labrador Retrievers, Rottweilers, English Bulldogs, Shih Tzus, Australian Shepherds, Staffordshire Terriers and mixed breed dogs. Dogs with\n                    <jats:styled-content style=\"fixed-case\">PAHS<\/jats:styled-content>\n                    were more likely to have prior joint disease in the tumour\u2010affected joint compared with the control population (odds ratio [\n                    <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                    ]\u2009=\u200913.42,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.0001, 95% confidence interval [\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    ]\u2009=\u20094.33\u201048.63). A total of 88.2% of dogs with stifle\n                    <jats:styled-content style=\"fixed-case\">PAHS<\/jats:styled-content>\n                    had prior joint disease in their tumour\u2010affected joint, most commonly cranial cruciate ligament rupture. This study confirms that the previously noted association between prior joint disease and\n                    <jats:styled-content style=\"fixed-case\">PAHS<\/jats:styled-content>\n                    in Bernese Mountain Dogs also applies to other breeds. Additional studies are needed to further investigate for a causal relationship.\n                  <\/jats:p>","DOI":"10.1111\/vco.12338","type":"journal-article","created":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T22:36:55Z","timestamp":1503527815000},"source":"Crossref","is-referenced-by-count":20,"title":["Prior joint disease is associated with increased risk of periarticular histiocytic sarcoma in dogs"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5233-0007","authenticated-orcid":false,"given":"E. K.","family":"Manor","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences University of Tennessee  Knoxville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0013-7544","authenticated-orcid":false,"given":"L. E.","family":"Craig","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Diagnostic Sciences University of Tennessee  Knoxville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Sun","sequence":"additional","affiliation":[{"name":"Office of Information Technology University of Tennessee  Knoxville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0656-6916","authenticated-orcid":false,"given":"C. M.","family":"Cannon","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences University of Minnesota  St. Paul Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-1-74"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.43-5-632"},{"issue":"10","key":"e_1_2_7_4_1","first-page":"1041","article-title":"Canine histiocytic neoplasia: an overview","volume":"48","author":"Fulmer AK","year":"2007","journal-title":"Can Vet J"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5810.2006.00090.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985813510413"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12252"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.239.1.90"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-1-66"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1995.tb02838.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb02937.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2009.00186.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2008.00181.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/941275"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.13964"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12059"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12354"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3415\/VCOT-07-05-0054"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(97)50076-3"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2009.10.005"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20027"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2010.04.011"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.5326\/0400385"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2012.11.009"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jhered\/esp039"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01322"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(98)00229-3"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2003.09.007"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-31-4-289"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2008.05.023"},{"issue":"5","key":"e_1_2_7_31_1","first-page":"1166","article-title":"Synovial membrane changes after experimental transection of the cranial cruciate ligament in dogs","volume":"46","author":"Lipowitz AJ","year":"1985","journal-title":"Am J Vet Res"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3415\/VCOT-10-04-0055"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2011.00841.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2008.00481.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1053\/jvet.2002.31046"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2007.00322.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2011.01073.x"},{"issue":"10","key":"e_1_2_7_38_1","first-page":"1037","article-title":"Patellar luxation: pathogenesis and surgical correction","volume":"47","author":"Harasen G","year":"2006","journal-title":"Can Vet J"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287398909531360"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115944"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3229"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvco.12338","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12338","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T15:49:24Z","timestamp":1694965764000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.12338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,23]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/vco.12338"],"URL":"https:\/\/doi.org\/10.1111\/vco.12338","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,23]]}}}