{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:20:26Z","timestamp":1770747626632,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:00:00Z","timestamp":1505347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>T zone lymphoma (<jats:styled-content style=\"fixed-case\">TZL<\/jats:styled-content>) is characterized by the clonal expansion of T cells lacking expression of the pan\u2010leukocyte antigen <jats:styled-content style=\"fixed-case\">CD45<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">TZ<\/jats:styled-content> cells). A strong breed predisposition is observed in Golden retrievers. This study aimed to confirm aberrant <jats:styled-content style=\"fixed-case\">CD45 mRNA<\/jats:styled-content> expression and determine if Golden retrievers without clinical lymphoma have an increased frequency of circulating <jats:styled-content style=\"fixed-case\">TZ<\/jats:styled-content> cells. Gene expression analysis on confirmed <jats:styled-content style=\"fixed-case\">TZL<\/jats:styled-content> cases showed a significant decrease in <jats:styled-content style=\"fixed-case\">CD45<\/jats:styled-content> expression compared to normal dogs. Peripheral blood samples from senior dogs, 242 Golden retrievers and 42 non\u2010Golden retrievers, without evidence of lymphoproliferative disease were assessed for the presence of <jats:styled-content style=\"fixed-case\">TZ<\/jats:styled-content> cells by flow cytometry. Thirty\u2010one percent of Golden retrievers had <jats:styled-content style=\"fixed-case\">TZ<\/jats:styled-content> cells compared to 14% of non\u2010Golden retrievers. Thirty\u2010four percent of Golden retrievers with <jats:styled-content style=\"fixed-case\">TZ<\/jats:styled-content> cells had a clonal T cell receptor gamma (<jats:styled-content style=\"fixed-case\">TRG<\/jats:styled-content>) gene rearrangement. Interestingly, 20% of Golden retrievers without <jats:styled-content style=\"fixed-case\">TZ<\/jats:styled-content> cells also had a clonal <jats:styled-content style=\"fixed-case\">TRG<\/jats:styled-content> rearrangement. Golden retrievers may have an increased risk of <jats:styled-content style=\"fixed-case\">TZL<\/jats:styled-content> due to an increased frequency of <jats:styled-content style=\"fixed-case\">TZ<\/jats:styled-content> cells.<\/jats:p>","DOI":"10.1111\/vco.12343","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T07:58:53Z","timestamp":1505375933000},"source":"Crossref","is-referenced-by-count":15,"title":["Increased frequency of <scp>CD45<\/scp> negative T cells (T zone cells) in older Golden retriever dogs"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5034-2637","authenticated-orcid":false,"given":"K. 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