{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:29:15Z","timestamp":1788294555646,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T00:00:00Z","timestamp":1504828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Transitional cell carcinoma (TCC<\/jats:styled-content>) is the most common neoplasia of the canine urinary tract. It tends to be locally invasive and has a moderate metastatic rate. Receptor tyrosine kinases (RTKs<\/jats:styled-content>) play an important role in promoting cell growth, differentiation and regulation of cell function. RTK<\/jats:styled-content> inhibitor toceranib phosphate has been used anecdotally to treat TCC<\/jats:styled-content>. The goal of this study was to evaluate archived normal urinary bladder, TCC<\/jats:styled-content> and cystitis bladder samples for expression of toceranib phosphate targets: VEGFR2<\/jats:styled-content>, PDGFR<\/jats:styled-content>\u2010\u03b2 and stem cell factor receptor (KIT<\/jats:styled-content>). A significant number of TCC<\/jats:styled-content> samples expressed PDGFR<\/jats:styled-content>\u2010\u03b2 compared with cystitis and normal bladder samples (P<\/jats:italic><.0001). While all the tumour samples stained positively for VEGFR2<\/jats:styled-content>, there was no significant difference between tumour, cystitis and normal bladder samples in intensity scores or staining distribution. Minimal positive staining for KIT<\/jats:styled-content> was noted in the tumour samples. Based on this proof of target study, further investigation is warranted to determine clinical response of TCC<\/jats:styled-content> to toceranib phosphate.<\/jats:p>","DOI":"10.1111\/vco.12344","type":"journal-article","created":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T11:22:19Z","timestamp":1504869739000},"source":"Crossref","is-referenced-by-count":22,"title":["Expression of receptor tyrosine kinase targets PDGFR<\/scp>\u2010\u03b2, VEGFR2<\/scp> and KIT<\/scp> in canine transitional cell carcinoma"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9387-0341","authenticated-orcid":false,"given":"L.","family":"Walters","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine University of Tennessee Knoxville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine University of Tennessee Knoxville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Price","sequence":"additional","affiliation":[{"name":"Knoxville School of Information Sciences University of Tennessee Knoxville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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